Basic Information

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.24 8.5e+02 -0.5 1.1 49 88 59 100 53 103 0.67

2 3 1.5e-70 5.2e-67 223.3 0.0 5 129 107 231 103 231 0.98

3 3 1.4 4.9e+03 -3.0 0.0 28 55 257 284 252 299 0.59

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.24	8.5e+02	-0.5	1.1	49	88	59	100	53	103	0.67
2	3	1.5e-70	5.2e-67	223.3	0.0	5	129	107	231	103	231	0.98
3	3	1.4	4.9e+03	-3.0	0.0	28	55	257	284	252	299	0.59

Coding Sequence: ATGGTCACATCGTCGGCATCGCCAACAGGAACGGGAACGGGCTGGTCGGCACCTGGAGATTACAAGAGCGCCAACACCGCTGtcacagcagctgctgccactggGGTCATGTGCGAGGTGCTGCCGTCGAGCAGCGCCAGCGTTGGCAGCAGTTCGCCAACGGGAGGCGCCAGCAATGGCACCGCAAACAGCGCGCACAGTGGCAGCAATAagaatagcaacagcaacagtgcgaacaacaataacagcagcaacagcaacaataacaacgcaGTGCATCAGGATCTGCTTTGGATGGAAAGATTTGTGCTGGAGAGACAGCAGGAATACCCAGGAGAGTTGGtGCGAACGAGCAATCCTTACTTTCTCTGCTCCGCTCTGCCCTCCCACTGGCGCTCGAATAAAACGCTGCCGCTGGCATTTAAAGTCGTCGCCCTGGCGGACGTCGGAGATGGCACCTATGTCACCATACGAGCGGGAAATGATGAGAACTGTTGCGCCGAACTGCGCAACTACACAGCACAGATGAAGAGCGGTGTTGCCAAATTTAACGATCTGCGCTTTGTGGGACGCAGTGGACGAGgGAAAAGTTTTACGCTAACAATTACCGTTGCAACAAGTCCGCCACAGGTGGCTACCTATGCCAAAGCCATCAAAGTGACCGTTGACGGTCCAAGGGAACCGCGCTCCAAAACGAGTCCTCCGGGTGCTCCCCAGTATCGGGCACTGGGCTTAGGCCAGCGGCCATTCATCGATGGTTTCCCGAAAACTTTTCACGAACTGGAGACGCTGCGGCGATCAGCAAAAGTGGTGGCAGCGACGacggcagcggctgcggctgcgtcGACTGTGGCATCGGTGGCAACATCGGGCAATGTGCTAACGACGAGTGCGCAGCAATTGGAGAGCAACTACTCGTCATCGAACAGTACAATAAACTCAGACTGCCAGATCTATAAGCCGAACGCGCCACAGATTCAAGCCATCAAAGGAGACTCGTTGTGCCGTATGAGCTTCAAATGA
Protein Sequence: MVTSSASPTGTGTGWSAPGDYKSANTAVTAAAATGVMCEVLPSSSASVGSSSPTGGASNGTANSAHSGSNKNSNSNSANNNNSSNSNNNNAVHQDLLWMERFVLERQQEYPGELVRTSNPYFLCSALPSHWRSNKTLPLAFKVVALADVGDGTYVTIRAGNDENCCAELRNYTAQMKSGVAKFNDLRFVGRSGRGKSFTLTITVATSPPQVATYAKAIKVTVDGPREPRSKTSPPGAPQYRALGLGQRPFIDGFPKTFHELETLRRSAKVVAATTAAAAAASTVASVATSGNVLTTSAQQLESNYSSSNSTINSDCQIYKPNAPQIQAIKGDSLCRMSFK

Sequence clustering based on sequence similarity using MMseqs2