Dlac007267.1
Basic Information
- Insect
- Drosophila lacertosa
- Gene Symbol
- lz_1
- Assembly
- GCA_004143845.1
- Location
- SCDZ01000817.1:11724-24799[+]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 3 0.41 2.8e+03 -2.0 0.5 49 84 23 55 19 61 0.64 2 3 2e-71 1.4e-67 225.4 0.0 5 129 66 190 62 190 0.98 3 3 0.14 9.5e+02 -0.4 0.0 24 60 212 248 207 260 0.79
Sequence Information
- Coding Sequence
- ATGTGCGAGGTGCTGCCAtcgagcagcgccagcgttGGCAGCAGCTCACCGACAGGTGGCGCCAGCAATGGCACCGCCAATAGTGCACACAGTGGgagtaacaaaaacaatagcaaccataataataacagcagcaataacaacaatgccgTGCATCAGGATCTGCTGTGGATGGAAAGATTCGTTCTGGAAAGACAGCAAGAGTATCCAGGAGAACTGGTGCGTACGAGCAATCCGTACTTTCTGTGCTCCGCCCTGCCCTCCCACTGGCGGTCGAACAAAACACTGCCGCTGGCGTTCAAAGTAGTCGCCCTGGCGGACGTCGGCGACGGCACCTATGTCACCATCCGAGCGGGAAACGACGAGAATTGCTGCGCGGAACTGCGAAACTATACCGCCCAAATGAAGAATGGCGTCGCCAAGTTTAACGATCTGCGCTTTGTCGGTCGCAGCGGTCGAGGCAAGAGCTTCACGCTAACAATTACCATTGCAACAAGCCCCCCACAAGTGGCCACCTATGCCAAAGCTATCAAAGTGACCGTCGACGGTCCGCGGGAGCCGCGCTCAAAGACGAGCCCATCCGGCGGCCCACAGTACCGAGCACTGGGCCTGGGTCAGCGGCCATTCATCGATAGCTTCCCGAAAACTTTCCACGAGCTAGAAACGCTGCGGCGCTCCGCGAAGGTGGCGGCTGCGacgacggcagcagctgctgctgcggtgtCCGTTGCAACGGGTGGCAATACGTTGACCACAAACGCGAGCATGGCCCAGCAATTGGGCAGCAATTACTCATCCTCGAATAGTACAATAAATTCGGATTGCCAGGGCTACAAGCCCAATGCGCCACAAATTCAAG
- Protein Sequence
- MCEVLPSSSASVGSSSPTGGASNGTANSAHSGSNKNNSNHNNNSSNNNNAVHQDLLWMERFVLERQQEYPGELVRTSNPYFLCSALPSHWRSNKTLPLAFKVVALADVGDGTYVTIRAGNDENCCAELRNYTAQMKNGVAKFNDLRFVGRSGRGKSFTLTITIATSPPQVATYAKAIKVTVDGPREPRSKTSPSGGPQYRALGLGQRPFIDSFPKTFHELETLRRSAKVAAATTAAAAAAVSVATGGNTLTTNASMAQQLGSNYSSSNSTINSDCQGYKPNAPQIQ
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00508099;
- 90% Identity
- iTF_00547135;
- 80% Identity
- -