Basic Information

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 3 1.3e+04 -3.8 2.5 50 71 58 79 53 109 0.54

2 2 2.5e-71 1.1e-67 226.0 0.0 5 129 115 239 111 239 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	3	1.3e+04	-3.8	2.5	50	71	58	79	53	109	0.54
2	2	2.5e-71	1.1e-67	226.0	0.0	5	129	115	239	111	239	0.98

Coding Sequence: ATGGTCACATCCTCGGCATCGCCAACAGGAACGGGCTGGTCAACGGCTGGAACGGCTGATTACAAAAGCGCCAACACAGCTGTATCTGTAGCGTCTGCAGTGATGTGCGAGGTGCTGCCGTCGAGTAGCGCCAGTGTTGGCAGCAGCTCACCAACAGGTGGCGCCAGCAATGGCACCGTCAATAGTACACATAGTGGtagcaataaaaatagcaataacagtgttaataacaataacaacaacaacacccataacaacaacaacagcaacaacaacaacagtagtaACCATAATGCTGTTCATCAGGATCTGTTGTGGATGGAAAGGTTTGTGTTGGAAAGGCAACAGGAACATCCTGGAGAATTGGTTCGAACGAGTAATCCGTATTTTCTCTGCTCCGCTCTGCCCACCCACTGGCGTTCAAACAAAACGCTACCGCTGGCCTTTAAAGTCGTCGCCCTGGCGGACGTCGGCGACGGCACGTATGTGACGATAAGGGCGGGAAACGATGAGAACTGCTGCGCCGAGTTGCGGAACTACACGGCTCAGATGAAGAATGGTGTGGCCAAGTTTAATGATCTGCGTTTCGTGGGACGCAGCGGAAGAGGGAAAAGTTTCACGCTTACAATTACCGTTGCAACAAGTCCGCCACAGGTGGCTACTTATGCCAAAGCCATCAAGGTAACTGTGGATGGGCCAAGGGAACCGCGCTCTAAGACGAGTCCTCCTGGTGGTCCTCAGTATAGAGCACTGGGTCTGGGGCAACGGCCATTTATTGATGGTTTTCCGAAAACCTTTCACGAATTGGAAACACTGCGACGGTCGGCGAAGGTGGCTGGTGTTGCGTCCGCTGCCGCGTCAACTGCGTCTGCAACTGCGGGAAATGCGTTAACCACAAGTGCGCAGCAACTGGGTAGCAATTACTCATCGTCTAATAGTACAATAAATTCAGATTGCCAGGTCTATAAACCTAATGCGCCCCAAATTCAAGGTAAGTTCTCTAAAACTGAGCTACTCTCCAATAACCTGCACATTCTCCAATTTCTTGTATAA
Protein Sequence: MVTSSASPTGTGWSTAGTADYKSANTAVSVASAVMCEVLPSSSASVGSSSPTGGASNGTVNSTHSGSNKNSNNSVNNNNNNNTHNNNNSNNNNSSNHNAVHQDLLWMERFVLERQQEHPGELVRTSNPYFLCSALPTHWRSNKTLPLAFKVVALADVGDGTYVTIRAGNDENCCAELRNYTAQMKNGVAKFNDLRFVGRSGRGKSFTLTITVATSPPQVATYAKAIKVTVDGPREPRSKTSPPGGPQYRALGLGQRPFIDGFPKTFHELETLRRSAKVAGVASAAASTASATAGNALTTSAQQLGSNYSSSNSTINSDCQVYKPNAPQIQGKFSKTELLSNNLHILQFLV

Sequence clustering based on sequence similarity using MMseqs2