Dcog005565.1
Basic Information
- Insect
- Drosophila cognata
- Gene Symbol
- MBD-R2
- Assembly
- GCA_035041535.1
- Location
- JAWNLC010000238.1:3481527-3486066[+]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 2.4e-20 5.4e-17 61.2 0.1 4 76 450 520 447 521 0.93
Sequence Information
- Coding Sequence
- ATGGGGCGCCGCTGCTGCGTTTCTGAATGTCCGTCGACGTCGCGGCTCTTTGAGCACCACGGCGTCACTTACCACTCGTTCCCAATGGACCCCGTCATACGGGCAATTTGGATCAAGAACTCGCGCACAAGTCTCGATCGATTGATTACAAAGAGTGTGCTTGTCTGTTCGCGTCACTTTCGACGGCTCGATTTTAATACCGTGCgcaatggaaaatatttgctaaagCCGCGTGTTTTTCCCACCGTCTTTCCGTGGGGCAAAATGGAACCCGCTGAGATCGAGGCTGATCAGCGTGCACTGCAACAGGCGACAGTGGATGGAGTTGGGGTCAGCGGTACCACAAACAGTGCCTCCAGCGAAGACTTGATCAGAGCAACAGTGGACCAAATTGTTGCCCAAATCCATGCCGAGACTGCAGAGCGGAATGCAGccgcggctgctgcagccgtGGCAGCATCCAAAGCCGAAGCTGAAGTGCAAGCAGAAGCTGctaaagaagaagcagagtcTTCGGCACCTGCTGCTGAGATTAAAATGGATATAACTGTATCAGAGGATTCCGTCGTTGCCGGCACAGCTGAGTCCGGTAACGAAACGCTGCCAGATGCCAGCAGTGCCAATTCCCCCTTGTCTGTCACATCCCCCAATTATGGACTCCCCACAAACCTGACGATTGGCGCACGTCTCGAGGCGTTAAGCGCTGATGGCGCATGGCTGTCCGCACGTATCGTCGAAGTCAACGATAAGGAGGAGACGCTCCTTATACGCTTCGAGCGCAATAGCAAGCTAAAAGTGTTGCCCTCGACGAACGGCAGCTACCAGGAATGGATGGGTTTCAAATCGGATCGTTTGCGTCAGCGCATCAGCTCGCGTGTGCTGCCCGTCTTTGAGCTGGATGAGAAGTGCATGGCACGCTGGTCCGGACCGCGTAAATTTCCGGGCACCGTCAGGAAGCAGCTTGGCAGCGACACCTACGAGGTGCTCTTCGATGATGGCTACACAAAGAATGTGCGCGCCGTCCACATGACCAAGTTGCCGCgtcagctgccagctgcgGTATCTGAGACAGCCAGTGAATCCTTGAGCGCAGAGTCAACTACAGTCACACttgcagttggagttggaatTAAAAGACCAAGCTCTGGTCCTACCAGCACCAATAAGAAGAGCAAGGCGACATCACAACGCAAGGACTGGCCATTACTGGATATGTCTACTTTGGATTTAGGTGCTTTGGGACTGCCGGACATACCGCACGATGGTGAATGGACCTGCCACTGGGTAAATGATCAACCCATTGGCACCGAAGGTTTTCTCATTGTGGGTGAGCACCAGAAGCCAACGGTAATTGTACACGATTGGCGGCTGCCGGATGGTTGGATCAAGCACATGTATCAACGCTCCAATGTGCTGGGGAAGTGGGATGTCATTCTGGTATCGCCCAGTAGCAAACGATTTCGCTCCAAGTCCGATCTCAAGGTGTTTCTGGAATCGCAGGGCGAGGTCTACAATCCGGATGTGTACGATTTTAGTATTCATCGTCGACGCGCCAAGGACATCAATGcctatgtatatacacacgaCTATAGTCCGCAGCAGCCGGTCAAGCCAAAACCATTAGACGTCTCCCTGGACACTACTGCAACATTGCAAGATTTGAACGGCAGCAAATTATCGACTGTCACACCCACATCTACGCCCATATCGGCCATGGGTACGCGACGCAATGCAACTGAGGAGAGTCAGTACATGGAAACACCAGTGGCCTCATTGGTGCCACCCGCGGAGCTGATGTCGCCTTCGCCACACGCCCAAGGAGTTGAGACACTGCCGCCCACAGCTGATGCAGTTGCACCCAGCTCTGCTTCTGGCATGGAAGAGCATGGCGCCGTTGTTGTGGAAGATGGTTGCGCCTTCATTGGCGGTCTGAAAATTCATATAACCGACAATTTGTTCGTCTGCCCTCGCGAGGGTTGCGGCAAATCCTTCCGAAAAGAAGATTTTCTACAAATACACATTCGTCATTACCACAAGGAACTTGCCgagCACGTCAGTCACTGTCCTAAGATGCAGGAGCTGGCCGTTAAGCGCACGCATCTCTCATCAATTGAGCAGAACGATCAGACgcccaaaaatcaaataccCAACCAGCAGTTCTTTGCCAAGCTGCACCAGCAGGATTTACAGCAATCGCGATCCTTTCGACGTCACCCAGTGGGTACAGAAACATCGCCATCGGCTCGGGATACATCtccaaatattttgccaatCAGTGCAATAAAATCAGAACCGCTAACGCCACCAGAATCTGCATTAGCGACAGCTATAGCTGTTGGTCCAGTGACTAGTGAAGTTGCGACACCAATTTCTGTAGACTCAATCAAATCGGAAACACCAATCGCCACGACGTCGTCCAATCGATCTGTCAAACGTGCGCGTCCGTCATCTAGAAGACGTCAGTCCGGCTCACGTAAGAGCAGTCGTCAACGCACACAGCGTCGTCCAGTGAATTCATCTCAAAGAAGAATTCCTGCTATAGGCGGTAATTCGAGAAACTTGCCAGTCTCGGGGGTAGATCACGAGTCCCGTAACGATCCCAAGAAGCGACGCATAGGTACCTCGGGAACATCGGCTGGCTCGCCTGCTAACATCGTGTTGGTGCCGAGACCATCATCAAACGATTTAGTTGACATAAATGCAGCTTTACCGCCGCCGCCTGCTCCACCATTGGGCACCCAGACGCCGCAATACATCAATGAGAATGGAGAATTAATACGCATTGTGCGTATGCGGCAGGAGGAAATCATTAACTGTACTTGCTGCTACGGCGATGAGGATGGGCTGATGATACAGTGTGAACTATGCCTGTGCTGGCAGCACGGCCACTGTTACGGAATTTTCAAGGAGTCGGACGTGCCGGAGAAGTATGTCTGCTATATTTGCCGCAATCCGCAACGCATGCGCGAATCAATGCGCTTTAAGCATGATCAGGAGTGGCTATTCGAGGGCAAACTGCCAGTGGCTGGCTATCACACGCCTAATCAGCAGTCGTCCAAGAAGTTCGAACTTTTGAAGCAGTCTCACACTTTAACCGGCAATTTGCTGGATGCTAAGCGTTTTATGCACTCGCTGCAGGTCAAGATCAATATAGCTCGCAATCGCTGCCACCCCAAGTTGTATCTGTGGGCCAAGAAGTGGGACGAGGATCAGACAGATTCCTCGCCCGTCAAGCGACCAAAGGTCGAACAGCCCAATTGGCCACATGTGCCACAACCTGAGGCTGCCATCGATCCTGAGGAGTGTCAATACCGTTTAATTGAACATGTCAAGGTACAACAATCACTATTGATGAGTCGCCTTAATGACATTGAAGCTGAAATGGATGAACTTGAAAATGGGGACTATCTGGTCGATCTTAAAGACTCAAACATATCGACAACCAAAGAAGCCATGGCCACGTTTATTAAGGAGCTAGAGATAATGAAGCGTCTTGCAAAGCTCAACAATGTGGCCAACATGAAGCAGTCTCTAAAGGACCAAGAATCGGTGTCCGAAATTACTCATGCGTAA
- Protein Sequence
- MGRRCCVSECPSTSRLFEHHGVTYHSFPMDPVIRAIWIKNSRTSLDRLITKSVLVCSRHFRRLDFNTVRNGKYLLKPRVFPTVFPWGKMEPAEIEADQRALQQATVDGVGVSGTTNSASSEDLIRATVDQIVAQIHAETAERNAAAAAAAVAASKAEAEVQAEAAKEEAESSAPAAEIKMDITVSEDSVVAGTAESGNETLPDASSANSPLSVTSPNYGLPTNLTIGARLEALSADGAWLSARIVEVNDKEETLLIRFERNSKLKVLPSTNGSYQEWMGFKSDRLRQRISSRVLPVFELDEKCMARWSGPRKFPGTVRKQLGSDTYEVLFDDGYTKNVRAVHMTKLPRQLPAAVSETASESLSAESTTVTLAVGVGIKRPSSGPTSTNKKSKATSQRKDWPLLDMSTLDLGALGLPDIPHDGEWTCHWVNDQPIGTEGFLIVGEHQKPTVIVHDWRLPDGWIKHMYQRSNVLGKWDVILVSPSSKRFRSKSDLKVFLESQGEVYNPDVYDFSIHRRRAKDINAYVYTHDYSPQQPVKPKPLDVSLDTTATLQDLNGSKLSTVTPTSTPISAMGTRRNATEESQYMETPVASLVPPAELMSPSPHAQGVETLPPTADAVAPSSASGMEEHGAVVVEDGCAFIGGLKIHITDNLFVCPREGCGKSFRKEDFLQIHIRHYHKELAEHVSHCPKMQELAVKRTHLSSIEQNDQTPKNQIPNQQFFAKLHQQDLQQSRSFRRHPVGTETSPSARDTSPNILPISAIKSEPLTPPESALATAIAVGPVTSEVATPISVDSIKSETPIATTSSNRSVKRARPSSRRRQSGSRKSSRQRTQRRPVNSSQRRIPAIGGNSRNLPVSGVDHESRNDPKKRRIGTSGTSAGSPANIVLVPRPSSNDLVDINAALPPPPAPPLGTQTPQYINENGELIRIVRMRQEEIINCTCCYGDEDGLMIQCELCLCWQHGHCYGIFKESDVPEKYVCYICRNPQRMRESMRFKHDQEWLFEGKLPVAGYHTPNQQSSKKFELLKQSHTLTGNLLDAKRFMHSLQVKINIARNRCHPKLYLWAKKWDEDQTDSSPVKRPKVEQPNWPHVPQPEAAIDPEECQYRLIEHVKVQQSLLMSRLNDIEAEMDELENGDYLVDLKDSNISTTKEAMATFIKELEIMKRLAKLNNVANMKQSLKDQESVSEITHA
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00535349;
- 90% Identity
- iTF_00619873; iTF_00497378; iTF_00593093; iTF_00574086; iTF_00560263; iTF_00528040; iTF_00566826; iTF_00495147; iTF_00558702; iTF_00497423; iTF_00593136; iTF_00482225; iTF_00528084; iTF_00619832; iTF_00574041; iTF_00560317; iTF_00482270; iTF_00558654; iTF_00566784; iTF_00521389; iTF_00521345; iTF_00597398; iTF_00597353; iTF_00496634; iTF_00496591; iTF_00607099; iTF_00607058; iTF_00609920; iTF_00609876;
- 80% Identity
- iTF_00495147;