Basic Information

Insect: Drosophila kokeensis
Gene Symbol: MBD-R2
Assembly: GCA_035042145.1
Location: JAWNLT010000467.1:1994750-1999156[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 2.7e-22 5.3e-19 67.6 0.1 4 76 450 520 447 521 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	2.7e-22	5.3e-19	67.6	0.1	4	76	450	520	447	521	0.93

Sequence Information

Coding Sequence: ATGGGGCGCCGCTGCTGCGTTTCTGACTGTCCGTCGACGTCACGGCTCTTTGAGCACCACGGCGTCACTTACCACTCGTTCCCAATGGACCCCGTCATACGGGCCATTTGGATCAAGAACTCGCGCACAAGTCTCGATCGATCAATTACAAAGAGTGTGCTTGTCTGTTCGCGTCACTTTCGACGGCTCGATTTTAATAACGTGCGCCatggaaaatatttgctaaAGCCGCGTGTTTTTCCCACCGTATTTCCGTGGGGCAAAAAAGAACCCGCTGAGATCGAGGCTGATCAGCGTGCACTGCAACAGGCGACAGTAGATGGAGTTGGGGTCAGCGGTACCACAAACAGTGCCACCAACGAGGACTTGATCAGAGCAACTGTGGACCAAATTGTTGCCCAAATCCATGCCGAGACTGCAGAGCGCAATGCAgccgcggctgctgcagccgaggcagcagccaaagccGAAGCTGAAGTGCAAGCAGAAGCTGCTAAGGAAGAAGCAGAGACTTCGGCACCTGCTGCTCAGAGTAAAATGGATGCAACTGTATCAGAGGATTCCGTAGCTGGCGGCACAGCTGAGTCCGGTAACGAAACGCTGCCAGATACCAGCAGTGCCAATTCGCCCTTGTCTGCCACACCCCCCAATTATGGACTTCCCACAAACCTGACGATTGGCGCACGTCTCGAGGCGTTAAGCGCTGATGGCGCATGGCTGCCCGCACGTATCGTCGAAGTCAACGATAAGGAGGAGACGCTCCTTGTACGCTTCGAGCGCAACAGCAAGATAAAAGTGTTGCCCTCCACGAACGGCAGCTACCAGGAATGGATGGGTTTCAAATCGGACCGTTTGCGTCAGCGCATCAGCTCGCGTGTGCTGCCCGTCTTTCAGCTCGATGAGAAGTGCATGGCACGCTGGTCCGGACCACGTAAATTTCCGGGTACCGTCAGGAAGCAGCTGGGCAGCGACACCTATGAGGTGCTCTTCGATGATGGTTACACAAAGAATGTGCGTGCCGTCCACATGACCAAGTTGCCGCGTCAGCTGCCCGCTGCGGGATCTGAGGTAGCCACTGAATCCCTGAGCGCAGAGTCAACAACCGTCCCACttgcagttggagttggaaTTAAAAGACCAAGCTCTGGTCCTACCAGCACCAATAAGAAGAGCAAGGCGACAACACAACGCAAGGACTGGCCTTTACTGGATATGTCTAATTTGGATTTAGGTGCTTTGGGACTGCCGGACATACCACACGATGGTGAATGGACCTGTCACTGGGTAAATGATCAGCCCATTGGCACCGAAGGTTTTCTCATTGTGGGTGATCATCAGAAGCCAACGGTAATTGTACACGATTGGCGGCTGCCGGATGGTTGGATCAAGCACATGTATCAACGCTCCAATGTGCTGGGAAAGTGGGATGTCATTCTGGTATCGCCCAGTGGCAAACGATTTCGCTCCAAGTCCGATCTCAAGGTGTTTCTGGAATCGCACGGCGAGGTCTACAATCCGGATGTGTACGATTTTAGTATTCATCGTCGACGCGCCAAGGACATCAATgcctatgtatatacacacgaCTACAGTCCGCAGCAGCCGGTTAAGCCAAAACCATTGGATGTCTCCCTGGACACCACTGCAACATTGCAAGATTTGAACGGCAGCAAATTATCGTCTGTCACACCCTCATCTACGCCCATATCGGCCATGAGTACGCGACGCAATGCAACTGAGGAGAGTCAGTACATGGAAACACCAGTGGCTTCATTGGTGCCACCCGCGGAGCTGATGTCGCCTTCGCCACACGCCCAAGGAGTTGAGAAACTGTCGCCCACAGCTGATGCAGTTGCACCCAGCTCTGTTTCTGGCATGGAAGAGCATGGAGCCGTTGTTGTGGAAGATGGTTGCGCCTTCATTGGCGGTTTGAAAATTCATATAACCGACAATTTGTTCGTCTGCCCTCGCGAGGGTTGCGGCAAAACCTTCCGAAAAGAAGATTTTCTACAAATACACATTCGTCATTACCACAAGGAACTTGCCGAGCACGTCAGTCACTGCCCTAAGATGCAGGAGCTGGCCGTTAAGCGCACGCATCCCTCATCAATTGAGCAGAACGATCAGACgcccaaaaatcaaataccCAACCAGCAGTTCTTTGCCAAGCTGCACCAGCAGGATTTACAGCAATCGCGATCCTTTCGACGTCACCCAGTGACCACAGAAACCTCTGGATCGGCTCTGGACACATCTCCAAATATTTTGCCTAGCAGTGCAGTAAAATCAGAATCGCCAACGACACCAGAATCTGCATTAGCGACAGCCGCAGCTGTTGGTCCAGTGACTAGTGAAGTTGCGACACCAACTCCACTAGACACAAGTAAGTCCAGTATACCAATCGCCACGACGTCGACCAATCGATCTGTCAAACGTGCGCGTCAGTCATCCAGAAGACGTCAGTCTGGCTCCCGTAAGAGCAGTCGTCAACGGACACAGCGTCGTCCAGTGAATGCACCCCAAAGAAGAATTCCTGCTACAGGCGGTAAATTGAGAAACTTGCCAGTCTCGGGGGTAGATCACGAGTCCCGTAACGATCCCAAGAAGCGACGCATAGGTACCTCGGGAACGCCGGCTGGCTCGCCTGCCAACATCGTGTTGGTGCCGAGACCATCATCAAACGATCTAGTTGACATAAATGCAGCTTTGCCACCGCCGCCTGCCCCACCATTGGGCACCCAGACGCCGCAATACATCAAGGAGAATGGAGAATTAATACGCATTGTGCGCATGCGGCAGGAGGAAATCATTAACTGTACTTGCTACTACGGCGATGAGGATGGCTTGATGATACAGTGTGAACTCTGCCTGTGCTGGCAACACGGCCACTGTTACGGCATTTTCAAGGAGTCGGAAGTGCCGGAGAAGTATGTCTGCTATATTTGCCGCAATCCGCAACGCATGCGCGAATCAATGCGCTTTAAGCATGATCAGGAGTGGCTATTCGAGGGCAAACTGCCCGTGGCTGGCTATCACACGCCTAATCAGCAGTCGTCCAAGAAGTTTGAGCTTTTGAAGCACTCTCACACTTTAACCGGCAATTTGCTGGATGCTAAGCGTTTTATGCACTCGCTGCAGGTCAAGATCAATATAGCTCGCAATCGCTGCCACCCCAAGTTGTATCTGTGGGCCAAGAAGTGGGATGAGGATCAGACAGATGCCTCGCCCGTCAAGCGACCAAAAGTCGAACAGCCCAATTGGCCACATGTGCCACAACCTGAGGCTGCCATCGATCCTGAGGAGTGTCAATACCGTTTAATTGAACATGTCAAGGTACAACAATCACTATTGATGAGTCGCCTCAATGACATTGAAGCTGAAATGGATGAACTTGAAAATGAGGACTACCTGACCGATCTTAAAGAGTCAAACATATCGACAACCAAAGAAGCCATGGCCACGTTTATTAAGGAGCTAGAGATAATGAAGCGTCTTGCAAAGCTTAACAATGTGGCCAACATGAAGCAGTCTCTAAAGGACCAAGAATCGGTGTCCGAAGTTACTCAAGCGTAA
Protein Sequence: MGRRCCVSDCPSTSRLFEHHGVTYHSFPMDPVIRAIWIKNSRTSLDRSITKSVLVCSRHFRRLDFNNVRHGKYLLKPRVFPTVFPWGKKEPAEIEADQRALQQATVDGVGVSGTTNSATNEDLIRATVDQIVAQIHAETAERNAAAAAAAEAAAKAEAEVQAEAAKEEAETSAPAAQSKMDATVSEDSVAGGTAESGNETLPDTSSANSPLSATPPNYGLPTNLTIGARLEALSADGAWLPARIVEVNDKEETLLVRFERNSKIKVLPSTNGSYQEWMGFKSDRLRQRISSRVLPVFQLDEKCMARWSGPRKFPGTVRKQLGSDTYEVLFDDGYTKNVRAVHMTKLPRQLPAAGSEVATESLSAESTTVPLAVGVGIKRPSSGPTSTNKKSKATTQRKDWPLLDMSNLDLGALGLPDIPHDGEWTCHWVNDQPIGTEGFLIVGDHQKPTVIVHDWRLPDGWIKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKVFLESHGEVYNPDVYDFSIHRRRAKDINAYVYTHDYSPQQPVKPKPLDVSLDTTATLQDLNGSKLSSVTPSSTPISAMSTRRNATEESQYMETPVASLVPPAELMSPSPHAQGVEKLSPTADAVAPSSVSGMEEHGAVVVEDGCAFIGGLKIHITDNLFVCPREGCGKTFRKEDFLQIHIRHYHKELAEHVSHCPKMQELAVKRTHPSSIEQNDQTPKNQIPNQQFFAKLHQQDLQQSRSFRRHPVTTETSGSALDTSPNILPSSAVKSESPTTPESALATAAAVGPVTSEVATPTPLDTSKSSIPIATTSTNRSVKRARQSSRRRQSGSRKSSRQRTQRRPVNAPQRRIPATGGKLRNLPVSGVDHESRNDPKKRRIGTSGTPAGSPANIVLVPRPSSNDLVDINAALPPPPAPPLGTQTPQYIKENGELIRIVRMRQEEIINCTCYYGDEDGLMIQCELCLCWQHGHCYGIFKESEVPEKYVCYICRNPQRMRESMRFKHDQEWLFEGKLPVAGYHTPNQQSSKKFELLKHSHTLTGNLLDAKRFMHSLQVKINIARNRCHPKLYLWAKKWDEDQTDASPVKRPKVEQPNWPHVPQPEAAIDPEECQYRLIEHVKVQQSLLMSRLNDIEAEMDELENEDYLTDLKESNISTTKEAMATFIKELEIMKRLAKLNNVANMKQSLKDQESVSEVTQA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00535349;
90% Identity: iTF_00495105;
80% Identity: iTF_00528084;