Basic Information

Insect: Drosophila ambigua
Gene Symbol: ZNF296
Assembly: GCA_018150905.1
Location: JAECWS010000100.1:8144043-8148648[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 26 0.0042 0.28 11.5 1.0 1 23 215 237 215 237 0.94

2 26 0.0077 0.52 10.7 1.1 1 23 243 265 243 265 0.97

3 26 0.056 3.8 7.9 1.8 2 23 297 318 296 318 0.96

4 26 0.002 0.13 12.5 1.5 1 23 391 414 391 414 0.94

5 26 4.3 2.9e+02 2.0 1.1 2 22 422 442 421 442 0.94

6 26 0.47 32 5.0 1.5 1 23 451 473 451 473 0.97

7 26 0.18 12 6.4 0.4 3 23 485 505 483 505 0.96

8 26 0.057 3.9 7.9 2.6 1 23 589 611 589 612 0.94

9 26 0.0089 0.6 10.5 0.1 2 22 622 642 619 642 0.90

10 26 0.099 6.7 7.2 4.5 1 23 651 674 651 674 0.97

11 26 0.001 0.068 13.4 1.6 2 23 700 721 699 721 0.97

12 26 5e-06 0.00034 20.7 4.5 1 23 729 751 729 751 0.99

13 26 0.0029 0.2 12.0 0.9 1 23 906 929 906 929 0.94

14 26 0.014 0.92 9.9 0.2 2 22 937 957 936 957 0.95

15 26 0.22 15 6.1 0.5 1 23 966 989 966 989 0.87

16 26 1.6e-05 0.0011 19.1 1.2 2 23 1011 1032 1010 1032 0.97

17 26 5.4e-05 0.0036 17.4 2.5 1 23 1039 1061 1039 1061 0.98

18 26 0.0079 0.53 10.6 0.0 2 21 1088 1107 1087 1108 0.93

19 26 0.011 0.72 10.2 3.9 1 23 1154 1177 1154 1177 0.96

20 26 0.014 0.97 9.8 0.4 1 23 1214 1237 1214 1237 0.95

21 26 0.00026 0.017 15.3 1.5 1 23 1261 1284 1261 1284 0.97

22 26 4.9e-06 0.00033 20.7 0.2 2 23 1310 1331 1309 1331 0.95

23 26 0.00014 0.0092 16.2 2.9 1 23 1337 1359 1337 1359 0.99

24 26 3.3e-06 0.00022 21.3 2.0 1 23 1365 1387 1365 1387 0.97

25 26 1.7e-07 1.2e-05 25.3 2.4 1 23 1393 1415 1393 1415 0.99

26 26 0.0012 0.078 13.2 0.1 1 21 1421 1441 1421 1445 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	26	0.0042	0.28	11.5	1.0	1	23	215	237	215	237	0.94
2	26	0.0077	0.52	10.7	1.1	1	23	243	265	243	265	0.97
3	26	0.056	3.8	7.9	1.8	2	23	297	318	296	318	0.96
4	26	0.002	0.13	12.5	1.5	1	23	391	414	391	414	0.94
5	26	4.3	2.9e+02	2.0	1.1	2	22	422	442	421	442	0.94
6	26	0.47	32	5.0	1.5	1	23	451	473	451	473	0.97
7	26	0.18	12	6.4	0.4	3	23	485	505	483	505	0.96
8	26	0.057	3.9	7.9	2.6	1	23	589	611	589	612	0.94
9	26	0.0089	0.6	10.5	0.1	2	22	622	642	619	642	0.90
10	26	0.099	6.7	7.2	4.5	1	23	651	674	651	674	0.97
11	26	0.001	0.068	13.4	1.6	2	23	700	721	699	721	0.97
12	26	5e-06	0.00034	20.7	4.5	1	23	729	751	729	751	0.99
13	26	0.0029	0.2	12.0	0.9	1	23	906	929	906	929	0.94
14	26	0.014	0.92	9.9	0.2	2	22	937	957	936	957	0.95
15	26	0.22	15	6.1	0.5	1	23	966	989	966	989	0.87
16	26	1.6e-05	0.0011	19.1	1.2	2	23	1011	1032	1010	1032	0.97
17	26	5.4e-05	0.0036	17.4	2.5	1	23	1039	1061	1039	1061	0.98
18	26	0.0079	0.53	10.6	0.0	2	21	1088	1107	1087	1108	0.93
19	26	0.011	0.72	10.2	3.9	1	23	1154	1177	1154	1177	0.96
20	26	0.014	0.97	9.8	0.4	1	23	1214	1237	1214	1237	0.95
21	26	0.00026	0.017	15.3	1.5	1	23	1261	1284	1261	1284	0.97
22	26	4.9e-06	0.00033	20.7	0.2	2	23	1310	1331	1309	1331	0.95
23	26	0.00014	0.0092	16.2	2.9	1	23	1337	1359	1337	1359	0.99
24	26	3.3e-06	0.00022	21.3	2.0	1	23	1365	1387	1365	1387	0.97
25	26	1.7e-07	1.2e-05	25.3	2.4	1	23	1393	1415	1393	1415	0.99
26	26	0.0012	0.078	13.2	0.1	1	21	1421	1441	1421	1445	0.91

Sequence Information

Coding Sequence: ATGCTGCCCAGCAATATTTGCCGTACGTGTGCCCTGCATAACAAGAATTTGCTGCCCCTGTCCACTTCGTTGGACAAGAATACGAATAAAAGTTTTTATGATGTGCTCCAAGAACTGACGCAGATCGATCCCCTGCTGGAGAATGCTGACGACAATCTGCCCCAGCAGCTGTGTACGGATTGCTTGGACAGGCTGAAGAACGCGTACGCATTTGTAGAGCAGGCCAGAAAAGTCAATGGAGAGCTGCTGATGCGGCTGCAGGAATGTCTGGAGGAGAGCCCCATTGACATACCAGAGGAGCAGATTAAAACAGAGATCGACATTGATGAGGAGCAAAGAGATTTCAGTGATTCTGGAGATGCACAGAGATTGTCTGATGTGGATGTGGAGTCGGCTGGCGCGTGCTCTGTTGAGTACAAATGGACGCCAGAAAGTGACACCGAGGATGAAAATGCCGATGCACTCTCAAACGATGAAGATGATGATGTGGATGAGCAGCAGCAGCCCTACGCCTTGCGACGAAGTTCACGCAAAGCCAAGCCACCGGCGGATAGTGAAGACGAGGATGTGTTGCCCAACAAGCGGCGCCGTGGACGTCCTCCTGGTCTCGCCAAAAGCAAGTCTAGGAATTCCGAAGGTCGTCATGCCTGTGAGGTGTGCGGCAAAACGTTTTCCTGGTTCCGAGACATGAAGCGACACGCTCGCGCCCATTACGAGAAGGCCTCGTTCGTCTGCGACATCTGTGGCAAGGGATTCTTGCGCAAGGACAAGTACACGTTCCATCTACGCTCCCACGAGAAGCGAGAGGCCAAGTGCCAGGCCCTCCAGCTGAAAAACGAGTGGAGATACGCGGAGCGTTTGTACAGCTCCGGGCGACTAAAGCGAATACAATGCAAATTGTGTGGCCTGAAATGCCAGCGAATGCAGGAGCTCCGATCCCATTTGGTGAGTCACACTCTCACGGATGGTTTGACCACTCTGCGTGCGGACAGCGATGTGGTGAAGGAACATTTTGCCAGTGTGCCATTTGACCTGGAAACGATCAAGCAGCGGGTCTGCATGGAAATTGCCGAAGGGCAGCTGGAAAAGTACGCGTGTGTGGTTAATTTCCACGGCTACGAGCTGTGCCTGAGCGACTCTGACGATGAGCCTGCCGGTGGAGAGCCACCGTATCGTTGTGACCTGTGCAATCAGTCGTACACGCGAAAATATCGCATGGTGCGTCACACACTGGAGGAGCACACCCAATCGCCCATTTCGCAGCGTTGCAACCTGTGCAAAGTTGGTTTCGTGTGTGCAAAGCTCTTTGCACAGCACCAGCGGACCCAGTGCCAGAGCAAAGTGAAGCGCTATCGCTGCCGCAAGTGTCCGGGGAAGTTCATGTGGCTGGAGAATCTGGAGCGGCATGCCTGCTCCCATCGCAAGGAGGAGCAGTCGTACAGGCAAATCATCTGCTGCCTGTGCGATGTTCAGCTGTACAGCTTGAGGCAGCTGCGCGCACACCTGGCCACCCATCAACATGGATTGAGTGGCATTGATCCGGAGCAGAAGGCCACCTTCTTCCGTTCTTACTATCCCAACGGATTGGGTTGCAGCCTCTCCGAGCTGAGCTCCCGCATAGCTGTGGACTATGATGCCCAAGACTTTGGACGCTACTACAACGCCTGCACTGGAAGTGGTGAAGAGCTGGATCTCTTTGACTCCGACTCCGAGGAGGGCGATGTGCACGAAACAGACGACACAGACGAAAAGCCGAAACTCTTGCACATCTGCCTGCTGTGTGGAGAGACTTCCATTCGTCTGCTCAAGCTGTTGCAACATCAGAGGAGACACCACTGCGCAGAGGACAGCACGTACCCCTGCTCTTGCCAGGATTGTGGCGCTGGCTTCGTGTCCGATGCCTTGCTGGAGCAGCATCGCAGACGATCCTGTGCTAAGAAGCACTCGAAATACCACTGCCAGCAATGCAATCTTCATTTTGTGTGGCAATCGAACTACGAGCAACATCTGCGATTGTACCACTCCAAGGATGAGGATCAGGAGCAGTCGGAGGACTGCCAGCAGGGTAGAAAATATAAATCTTCGCCCGTCAAGCTACAGTGCGATGAATGTGAAAAGGTCTTCATTTGGCACAAGGATCTCACGCGTCACAAGCGAATGCACCGCCCTCCGTCGGCAGCCCAATACGAGTGTGGCCATTGCGACCGCAAGTTCCATCGCAAGGATGGCCTCAAGTCCCACATGCGGGTGCACAACGAACAGCAGCAGCAGGAGGCGGCTGTAAATGAGGAGCAGCCTGCTTCCGCCCAGTCGACATCCACGAACAGTATTCAGCGAATGACCGGGGAGCAGCTGACCCAACTATGCCGTCCAAATGGCTGCAAGCAAATCCAGTGCATGATTTGCCTCTCGCGCCACTCGAAGATCGCCGACTTGAGGACTCACCTAAGCGGGCACCGGTATGGAGCGGGCTTTCCACCGGACAGGGATATTGGCAGTGCCTCGCGCTCGCTGTATCCCGAACTGGGCACTGCCCTGGACAAGCAGGAGCTGCTGGAGAGGATCATGAGCGATATGGCAAGCGGCTTGGAGTTGGAGCGATTCATTTCCATAACCAACGAGGCTGGCATTGAGCTCTCGCTGGAGAGCAGTGAAACGGAAACGGATTCAGAGCAGGAGGATGACGAGAGTTCCGAGGAAGCGGACCAGCAGCGCTACGCCTGCAACATTTGCCAGCTGGAGGTGAAACGGAAGCATCAGTTGTATGCCCACCAGTTGGAGCAACACCAGTGGGAGGAGGCGTCGCTTGTGTGCGCCCACTGCCAGGCAAGATTCGTGAGTGAGGCGCTGCTGGCGCATCACTACCGGACACTCTGCCGGAATACCCAGAAGCGCTTCCTGTGCCGCAAATGTCCGCTACGCTTCCGCTGGCAGGAAAACCTAAAGCTGCACGCCAGTGCCTCCCATCAGCAAAGGGAACAGATGCAACCAGCTGCAGAGGAGTCCAGCATTAAGGCCGAGTTCGAGCTGCAGTGTGGGGAGTGCAATCGCAGCTTCAAGATGCAGAAGGATCTCACGCGGCACACGCTGATGCATGCCCAGGAATCGAGCATTTATCGCTGTCATTGGTGTGCCCGCCGGTTCTACAGGAAGGCAAATCTCCTGCAGCACATTGAGCGGCACGGCATCGGAGCCAGCCAGCTGCCCTACGCGGAAGCTCTCCTCAATGCCTATGGCCATCCCAATGGGCAGAAGAGTGTGGAGTGCAAAGTGTGCAGCCTGAGCTTCTCCAGTATCGCTGCCCTTCGCGTTCACCTGGAGACCATGGCGCCGGGCAGTCACCACGAGCTGTCGTCCCACCAGAACTACTCGATAACCAACCATATGGGATTCGAGCTGCACTTGGATGACTCGGAGACGGATGAGGAGGAGTCCAAGCCACCGGGCACGCCTGCAACCTACACGTGTGGCATGTGCCAGCTGCGGTGTGTGCGAAAATACGAGCTGCATCAGCACCAGCAGGCCATGCACAGGCTGGAGAAGATTCCCGATGGCTGCGATCGGTGCATTTTCAAGAGCGTCTCCCCCGATCTTATCGCGCACCATAAGCGGGTGCAGTGCCACAACCAGGAGAAGCAGTTCAACTGCGCCAAATGCGGCTACAAGTTCATGTGGGAGTCCAATCTGCTGCTGCACATGCAGCTGCAGCACGGAAAGGCCGAAGAACAGGAAGACCCACCCCTGGATGAGCCCGCGGAGCAGAAGACTGTGTGCCAGATCTTTCAGTGCGGCCTCTGCCCCAGGAAGTACAATCGGAAGGATCGGCTGACGGCGCATGTGAAGAAGTTCCACAACCCAGTGGCAGGAACCCCAAGCGTCATACGGGCACCCATCCGTCCAGCGTCGCCCAAGGAGCCGAAACGCTTCCTTTGCGCCTTCTGTGGCAAGGCTGTGAGCTCCTCCTCGAACCTCATCATCCACATGCGACGGCACACGGGCGAGAAGCCCTTTAAGTGCGACTACTGCGAAATGGCCTTCCCGCGCTCCTCCGATCTGCAGTGCCATCGACGAACGCACACCGGCGAGCGGCCCCACATCTGCACCGTCTGCCAGAAGGGCTTCGCCAGATCCTACAAACTGCAGCAGCACATGCGCATCCACAGCGGCGAACGGCCCTACAAGTGCACCTACTGCGAGAAGAGCTTCACCCAGTCCAACGACCTGACGCTCCACATCCGCCGCCACACGGGCGAGCGTCCGTATCAGTGTGGAGTATGTGGCGAGCGTTTTATCCAGGGCACGGCCCTCAAGAACCATCGACTGCAGCAAGGACACTATGACGAGGCCAGCCAGGGAGCTGCACAGTCCGCAAGGCGCGCGGTCCTAGAGCAATTTGCAGTATAG
Protein Sequence: MLPSNICRTCALHNKNLLPLSTSLDKNTNKSFYDVLQELTQIDPLLENADDNLPQQLCTDCLDRLKNAYAFVEQARKVNGELLMRLQECLEESPIDIPEEQIKTEIDIDEEQRDFSDSGDAQRLSDVDVESAGACSVEYKWTPESDTEDENADALSNDEDDDVDEQQQPYALRRSSRKAKPPADSEDEDVLPNKRRRGRPPGLAKSKSRNSEGRHACEVCGKTFSWFRDMKRHARAHYEKASFVCDICGKGFLRKDKYTFHLRSHEKREAKCQALQLKNEWRYAERLYSSGRLKRIQCKLCGLKCQRMQELRSHLVSHTLTDGLTTLRADSDVVKEHFASVPFDLETIKQRVCMEIAEGQLEKYACVVNFHGYELCLSDSDDEPAGGEPPYRCDLCNQSYTRKYRMVRHTLEEHTQSPISQRCNLCKVGFVCAKLFAQHQRTQCQSKVKRYRCRKCPGKFMWLENLERHACSHRKEEQSYRQIICCLCDVQLYSLRQLRAHLATHQHGLSGIDPEQKATFFRSYYPNGLGCSLSELSSRIAVDYDAQDFGRYYNACTGSGEELDLFDSDSEEGDVHETDDTDEKPKLLHICLLCGETSIRLLKLLQHQRRHHCAEDSTYPCSCQDCGAGFVSDALLEQHRRRSCAKKHSKYHCQQCNLHFVWQSNYEQHLRLYHSKDEDQEQSEDCQQGRKYKSSPVKLQCDECEKVFIWHKDLTRHKRMHRPPSAAQYECGHCDRKFHRKDGLKSHMRVHNEQQQQEAAVNEEQPASAQSTSTNSIQRMTGEQLTQLCRPNGCKQIQCMICLSRHSKIADLRTHLSGHRYGAGFPPDRDIGSASRSLYPELGTALDKQELLERIMSDMASGLELERFISITNEAGIELSLESSETETDSEQEDDESSEEADQQRYACNICQLEVKRKHQLYAHQLEQHQWEEASLVCAHCQARFVSEALLAHHYRTLCRNTQKRFLCRKCPLRFRWQENLKLHASASHQQREQMQPAAEESSIKAEFELQCGECNRSFKMQKDLTRHTLMHAQESSIYRCHWCARRFYRKANLLQHIERHGIGASQLPYAEALLNAYGHPNGQKSVECKVCSLSFSSIAALRVHLETMAPGSHHELSSHQNYSITNHMGFELHLDDSETDEEESKPPGTPATYTCGMCQLRCVRKYELHQHQQAMHRLEKIPDGCDRCIFKSVSPDLIAHHKRVQCHNQEKQFNCAKCGYKFMWESNLLLHMQLQHGKAEEQEDPPLDEPAEQKTVCQIFQCGLCPRKYNRKDRLTAHVKKFHNPVAGTPSVIRAPIRPASPKEPKRFLCAFCGKAVSSSSNLIIHMRRHTGEKPFKCDYCEMAFPRSSDLQCHRRTHTGERPHICTVCQKGFARSYKLQQHMRIHSGERPYKCTYCEKSFTQSNDLTLHIRRHTGERPYQCGVCGERFIQGTALKNHRLQQGHYDEASQGAAQSARRAVLEQFAV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00471775;
90% Identity: iTF_00564064; iTF_00611480;
80% Identity: -