Basic Information

Gene Symbol
gprs
Assembly
GCA_949775195.1
Location
OX459202.1:15308505-15314173[-]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.5e-09 9.7e-07 30.4 0.0 9 45 36 73 29 91 0.84
2 2 7.2e-06 0.0046 18.5 0.0 43 81 119 157 107 163 0.71

Sequence Information

Coding Sequence
ATGCGAAGCGGGGCGCTAGCGGCCATGGAGGCAGAGCCGGACCTCAGCACCTTCGAGAACAAGTCAGGGCTGGCTGAGGACATGAAGTTCCTCGCCTCGATGCCCGAGCTGTGTGACGTCACGTTTCTGGTGGGCGATACCAGGGAGCCAGTGTGTGCTGTCAAGGCCGTACTGGCTGCAAGGAgcagAGTATTCCAAAAGATGCTCTACCAAGCTCCCAGTCCTCAACGGAAGAAGGAACCAGCTCCCAGGGAGAACAAACTACGGCTGTTCTTGAAAAGATCTTCGGAACCCCTGCTAAACCTTCAAAACGCCGCTCAGCAGAGATCGACTTTCGCGCAGCAATTGGCACCAATTCAAGagCCTTCATCGCAGCAGCATCAGACATTGATCATTGAAGAGTTCGAGCCTGATGTGTTTCGCCAACTGATTGAGTACATTCACACTGGATGCGTGACTCTGCAACCTAGGACACTGCTTGGGTTAGTTGGATACCGGGTAATTGGCAAATTTCATCCCAAACTGTGGTTTAGCGATAAGCTTACTAAGGAAATCACTAAAGCGTATCATGAATTTCCAGGAATTAATTTCCAATATTCATGA
Protein Sequence
MRSGALAAMEAEPDLSTFENKSGLAEDMKFLASMPELCDVTFLVGDTREPVCAVKAVLAARSRVFQKMLYQAPSPQRKKEPAPRENKLRLFLKRSSEPLLNLQNAAQQRSTFAQQLAPIQEPSSQQHQTLIIEEFEPDVFRQLIEYIHTGCVTLQPRTLLGLVGYRVIGKFHPKLWFSDKLTKEITKAYHEFPGINFQYS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00836751;
90% Identity
iTF_00013245;
80% Identity
iTF_00041962;