Csei021979.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Cyaniris semiargus
Gene Symbol
MBD-R2
Assembly
GCA_905187585.1
Location
LR994554.1:4475823-4489809[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 8.6e-15 4.3e-11 42.7 0.0 5 65 783 841 779 851 0.92

Sequence Information

Coding Sequence
ATGCTTATAAAAACATGTTGCGTTGAAAAATGTGAATCGTCGGCATCCCGGTCGGAAGATGTAGGTGTAACCTTCCATAAGTTCCCCAAAGACTTCAAGTTACACAGATCATGGCTTGAAGTTACCCACCATACACCTTGTAGCAATGCTCCCTCGTTTGTTTGCTCCAGACACTTTCGCAAAAACGATTTTAAAGTCTATCAGGATTCAAAATACGTACTAAAATCAGATTCCATACCTTCCATATTTACTTGGACACGCAAAATGGCAGATACAGAGCAAAAAGATGAAGAATCAAGCAACACACACTATTCTTCTGGCAGTAGTAAGGAGCCAGAAGAAAATATTGACACTATAATGAAGTTCATGGAACAACAAGATAAAGAAAAAGATGAGAAAAATCAAAATAATGTCAAATGTAATGATTCTAAATCAAAAGATATTTCAGAGGGAGGGGAGAAGAGTGCATCTAAAGATGCAGTGAAAGCTGATGCAAAAACCGATGTGAAATCAGCAAGTAGTGTCCTAGATATGTTGATGAGTGAGACAGAAAATAAGATTGAGGCCAAAAAAGAAATAAAGGCAACCTCAAAACTGAGCCCTACCTCTGGGGATAAAGGAAGCGTAGCTTTATCAGTAGGATCTAAGGTAGAAGCCAGAGACTATGCCAATGTATGGAATGCCGCAGAAATATTAGAAGTTGATTGTGATGAAATGGAAGTTTTGGTTCACTATGATAGTCTTGCTAATAAACCTGATGAGTGGATCAGTGTGAGCAGCTCTAGACTGAGACCGTTTAGTGTAAAACCTGTTGTCCGACCACAAACTACAACTGTTTCTCACATCGCACAGAAAATCACCAAGGAAGAAATGCCGGAAGATAAATTAAAACCAACATTTGCTGTTGGGGAAAGATGCCTGGCACGTTGGAGGGACAATCGACGCTTTGTCGCTACTATAAATCAAGTAATGGAGAATGGTTCATATGAAATAGTATTTGATGATGGATTTGCATGGAAATGTTCCACGTCAAGATTGTACAAACTGAAGAATACAGGGAAGATATCAGATAATCTGAGTATTGATACATCAGTCCATCCCACTGCGAGTCCAGCACATTCACCCATTCTGGAGGGAGTCGGGCCAAGTACTGGAACAGGAATGAAACCGTCCGCCTTACCTCCTTACCATACTCATCTCTTCGATCCAGCTCGCGATTATTTAGGCTCTAAAAAGGAGCGCCGTGAGATGAAACGAAAATTAAATATTAAAGAAATATTTAACATCGGGCAAAAGAAGAAAAAGACAGAAAAACCAGTACAAACTGTGAAACCGGTGAAGCCTGTTACAGAAAGAAAGAAGAGGCCTTACAATCGTAAAAAACAAGATGTATCAAAGAGTGTGCCAGAGGCAGTGGCTTCAATCATTGGTACTGTCGAGCAAAGTGAAGCTGCTGAGAAAATAAGTGGCAATGAATTAAACACACTGAATAATACAGAAAAAAAGAATGAGCCAATTGTCACTGAGAATCATCTAACATCTAAGGATGAAAGTAAAATTGCAATAGTCGATATGCCTGAACAGGATAGTTCTGACCTTTCAGACCCACAGACCACTGAAAACAATGTGTCAATGGAGACAGTCAGTGAAGAAGAAGCTAAACTGGTGAAATTTGATAAACCTGACGGGCACAAGCACGAAGAAGTTATAGACAAGATAAAAGAAGCTATAAATAAACTAGAAGATGGTTTAACGGAAATTAAAAAGGTTGATTCACCCAAGCCCCAATTGAAACTTGAAATTCCCAAACTTATTTTCAAGGATGAGAATACAAAACAGGAAATTGTAAAAGAAGAGACAGTTAAGGACGAAGTGGGTAATACAGAAATTACCAAAGAAGAACCCATAGAAAATATAGTAAATACAGAAGAAACAGCAAAAGAAATTAAAGATGAAGTTAAAGCATCAACTTTCAAATCTGAAATTGTGAAAGAGGAGTTGAAAACCAAAGAGGATTCAGAAGACAAACCAAAGAAGAAGCTATCGAAAATAAAGAAGAGTAAGAAATTGAGATTGTTACAAGAGAAGAAAGTAAAGAAGCAAGTGGAAAAGGTTAAGAACGAGCTGCAAGATATGAAGAGACAGATTGAGGAGATGCGGCTAGCGATGTTGAAGAAGACGGAGGAACTAGCGGCGCAGAACCAGGAAATGCCAGAGAGCTTCCTCTTGCCGGGGGAGTGGTGTTGCAAGTGGGTGAACGGGCAACCAGTAGGGACTGTCAGTGAAATGGGAAGTGAGACGCCCGTGGATAGTAATAATAAGCCCGGCTTGCCGCGACGAAGTGTGCAGGTGGAAGATAAGAGGTTACCGGAAGGGTGGACTAAACACATGGTGAGAAGAAGCCTCGGTCAGTCTGCTGGCAAATGGGATGTGGTTTTAGTTGGCCCTGACAATCGACGGTTTCACACGAAAACTGATATGCGTAATTTTCTGGAAAATCACGGCGAGTCGCTTAAGAGGTATGAAAATGCGCTGTTAGATTTCGGAGTTCATCTCAAACTAGCCAGACGAATGGGCTGGTATAAGACGACCGGCGAAGAGACGGCCCCGCCCACTGGAATAATTACTAACATGTCACCTCTAGTCAAAAGGAAGAGCATACTGAAGAAAGATAGGAAAGAAAAGAAGAGGAAATTGAAGATAAAATTCAAAAAATCTAATTCAGCATACAGTATTGCAACAGATAATGACCCAATAGAAAATCCACCAGAATCAACAGACATGTCGCTTTATAATACGGAATTGGAAGATGGCTTTGTGTTCGTTGGGTCTCTAAAAGTTCAAGTAGTCGATAACTTACTTCGCTGTCCTGCGGAAGGTTGTTTCAAAGCATTCAGAAATAACACTCTCATCAAAATGCATATAAAACATTACCACAGGGACCTCCGGAAAATGCTTGGCGTGACGCCGAAAGTTCTAGATTTGGCCTACGCTCGTTCGAAGTCGGTTAGCAAGGAGCAACAAAAGAAAAGACATGTGCCAACGCCTAAAACTGTCAAAGTCAAGGCGCCAAAGCTTAAGCGACCCGAGGAACCGAAATTGGAAGTACAGGGTATGCTTTCACTCGAATCGAAGGATGACAGTCTAAAACCACCGAGGTTGATCCCTAGATCTCTGGATTCGCCCAAACTACGTCAGAGCCTACAACAAGGGAACAAGCCAGTGAAACGACCTAAAGTATTACTCCCCGTCCGGAGACCAGAGCCCGAGGCTGTGGCAGAAGAAACAGTAGTCGAGTTTGACGATGTGAAAATAACGTTACCTGACATACCTCGACAGTTGGATTTCGAGGAGGCCATAACTACGCACACGGTGACTAAACCTGCAGATTTGATCAAGGAGAAGCGAACCACGAAGATGGAGGAGGATGAGTGGTTTGCTGCTTCTGACTACGACACCAGGTCCAGCTGTCCAGGGTCAGCCACGCCAGATTCCAAGACCATGGACAAACCAGCAGAGACCGATCAGTCTGCTTTTGACAATGTGGAGGATAAAGATGCAAACATGTACATGTATACTGAAACGGGTGAGAGGATCAAGTTGGAGCGTATGAAGCGCGAGGAGATCATCAACTGCCACTGCGGCTTCCGCGAGGAGGACGGGCTCATGGTGCAATGCGAGCTCTGCCTGTGCTGGCAGCACGCACTCTGCCATAACATACAGCGCGAAGCTGAGGTGCCGGAGAAGTACACGTGCAGCATCTGCCTCAACCCCAAGCGGGGTCGTCGCTCCGCGCGGTTCCTTCACGACCAGGATAGGCTATACGAGGGACTGCTGCCGGGGGCGCGAGCCTCAGACAGCCTACGCCGTTCACATGAACTCTCTGGGAACTTACTGCGAGTGCAGGACGCGCTGCACGCACTCCGCGTTAAATATTATGTTGCCACCAAGAAGAACCACCCCAAGTTGTATCTCTGGGCCAAGGACTGGGAGGCGGCGGAGATCTCCATGACGCAGGAGCGACTCAACTCTGATTATTCGGACCTAAACATCATCATCAACAACATCGGCAAGGAGAATTTGCCGGTGAAGGATGAGATGAGGGACTTGCATCTCGACTTGAGGTCTCTCCCGGATGACGACCACAAGGACTCGCTGCTGAGTCTCGCCAATGCGCTGTCTAGCCCCGGCGGAACGTCATTAGACCTGCCCATCAGTACGTCCGATTTGGAACGCCTGGCTAAGAGTGTTCAAGAGCAAGAGAGCCCGCGTCGCATGATAGTACCGCAGCCGGAAGCGGCGATCGACAACGGCGTGTGTCGCGAGCGGCTGCTGCGGCACCTCACGCGCTGCCAGGCGCTCATCGACGCGCGACTTGACTCTATAGAGGCGCAGGTCGTGGAACTGGAATCACAAGACCCATCATTTGAAGATGATGAAACAGCAGACTACTTCCCCAGGACTAAGCAGACAATACAGATGCTCATGCGAGACCTGGACACCATGGAGGAGTTGGGGATTATCACATAG
Protein Sequence
MLIKTCCVEKCESSASRSEDVGVTFHKFPKDFKLHRSWLEVTHHTPCSNAPSFVCSRHFRKNDFKVYQDSKYVLKSDSIPSIFTWTRKMADTEQKDEESSNTHYSSGSSKEPEENIDTIMKFMEQQDKEKDEKNQNNVKCNDSKSKDISEGGEKSASKDAVKADAKTDVKSASSVLDMLMSETENKIEAKKEIKATSKLSPTSGDKGSVALSVGSKVEARDYANVWNAAEILEVDCDEMEVLVHYDSLANKPDEWISVSSSRLRPFSVKPVVRPQTTTVSHIAQKITKEEMPEDKLKPTFAVGERCLARWRDNRRFVATINQVMENGSYEIVFDDGFAWKCSTSRLYKLKNTGKISDNLSIDTSVHPTASPAHSPILEGVGPSTGTGMKPSALPPYHTHLFDPARDYLGSKKERREMKRKLNIKEIFNIGQKKKKTEKPVQTVKPVKPVTERKKRPYNRKKQDVSKSVPEAVASIIGTVEQSEAAEKISGNELNTLNNTEKKNEPIVTENHLTSKDESKIAIVDMPEQDSSDLSDPQTTENNVSMETVSEEEAKLVKFDKPDGHKHEEVIDKIKEAINKLEDGLTEIKKVDSPKPQLKLEIPKLIFKDENTKQEIVKEETVKDEVGNTEITKEEPIENIVNTEETAKEIKDEVKASTFKSEIVKEELKTKEDSEDKPKKKLSKIKKSKKLRLLQEKKVKKQVEKVKNELQDMKRQIEEMRLAMLKKTEELAAQNQEMPESFLLPGEWCCKWVNGQPVGTVSEMGSETPVDSNNKPGLPRRSVQVEDKRLPEGWTKHMVRRSLGQSAGKWDVVLVGPDNRRFHTKTDMRNFLENHGESLKRYENALLDFGVHLKLARRMGWYKTTGEETAPPTGIITNMSPLVKRKSILKKDRKEKKRKLKIKFKKSNSAYSIATDNDPIENPPESTDMSLYNTELEDGFVFVGSLKVQVVDNLLRCPAEGCFKAFRNNTLIKMHIKHYHRDLRKMLGVTPKVLDLAYARSKSVSKEQQKKRHVPTPKTVKVKAPKLKRPEEPKLEVQGMLSLESKDDSLKPPRLIPRSLDSPKLRQSLQQGNKPVKRPKVLLPVRRPEPEAVAEETVVEFDDVKITLPDIPRQLDFEEAITTHTVTKPADLIKEKRTTKMEEDEWFAASDYDTRSSCPGSATPDSKTMDKPAETDQSAFDNVEDKDANMYMYTETGERIKLERMKREEIINCHCGFREEDGLMVQCELCLCWQHALCHNIQREAEVPEKYTCSICLNPKRGRRSARFLHDQDRLYEGLLPGARASDSLRRSHELSGNLLRVQDALHALRVKYYVATKKNHPKLYLWAKDWEAAEISMTQERLNSDYSDLNIIINNIGKENLPVKDEMRDLHLDLRSLPDDDHKDSLLSLANALSSPGGTSLDLPISTSDLERLAKSVQEQESPRRMIVPQPEAAIDNGVCRERLLRHLTRCQALIDARLDSIEAQVVELESQDPSFEDDETADYFPRTKQTIQMLMRDLDTMEELGIIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00403878; iTF_00933826; iTF_00934830; iTF_00933777; iTF_00934781; iTF_00164388; iTF_00164442; iTF_01248233; iTF_01248149; iTF_01217563; iTF_01217515; iTF_00744724; iTF_00744656; iTF_01178586; iTF_01178644; iTF_00288925; iTF_00288887;
90% Identity
iTF_00164388;
80% Identity
iTF_00403878;