Basic Information

Insect: Glaucopsyche alexis
Gene Symbol: MBD-R2
Assembly: GCA_905404095.1
Location: FR990050.1:20559805-20580100[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 8.3e-14 6.7e-10 39.6 0.0 5 64 764 821 760 844 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	8.3e-14	6.7e-10	39.6	0.0	5	64	764	821	760	844	0.90

Sequence Information

Coding Sequence: ATGCTAATAAAAACATGTTGCGTTGAAAAGTGTCCATCGTCGGCGTCCCGGTCGGAAGATGTAGGTGTAACATTCCATAAATTTCCCAAAGACTTCAAGTTGCGCAAATCATGGCTTGAAGTTACTCATCACAAACCTTGTAGCAATGTTCCTTCGTTTGTTTGCTCCAGACACTTTTGCAAAAACGATTTTAAAGCATATCAAGATTCAAAATACATACTGAAAGCAGATTCTATACCGTCTATATTTTCTTGGACAACAAAAATGGCAGATATAGAACACATTGTTAAAGAAACAGAGGGAAATCAAAACACATCAAGCAGTAATAAGGAGCCAGAAGAAAATGTTGATACTATAATGAAGTTTATGGAAGAACAAGACAAAGAAAAAGTGGAGAAAAATCAGAGTAATGTATACTCTAGTGATTCTCAGGTTCTGGAGGCTATATATCCAAAAGCTGATGTTAAATCAGCGAGTTGTGTACTAGACATGTTGATGAGTGAGACAAATAAAATTGCATACAAAAAAGATACAAAGCCCTCGCCAAAACCAATCACAACTTCTGGGGAAAAAGGCAGTGTAGCTTTATCCATTGGATCTAAAGTAGAAGCCAGAGACTATGCTAATGTATGGAATGCAGCAGAAATATTAGAAGTTGATTGTGATGAAATGGAGGTTTTGGTTCACTATGACAGTCTTGCTAATAAaccTGATGAGTGGATCAGTGTAAGCAGCTCTAGGTTAAGACCGGTCAGTGCAAAACCAATTGCCCCACCACAATCTACACCTGTTTCTCATATCACAGAGAATATCATCAAAGAAGAAATGCCAGATGACAGGGACAAGATAAAACCAACATTTGGTGTTGGAGAGAGATGTCTGGCTCGGTGGAAGGACAATCGTCGCTTCGTAGCTACTATAAGTAAAGAATTGGAGAATGgttcatatgaaataatatttgatgATGGGTTCACATGGAAGTGTTCTGCATTGAGACTGTACAAATTGAAAGATTCAGGGAAGATATCGGATAACCTGAGTATTGATACGTCGGTCCACCCAACTGCGACCCCGACACACTCGCCTATTTTGGAGGGAGTCGGGCCGAGCACTGGAACAGCCCTCAAACCTTCTGCCCTTCCTCCCTTTCACACACATCTCTTTGATCCCACTCGTGATTATTTGGGGTCTAAAAAGGAGCGCCGTGATATGAAACGCAAATTAAATATAAAGGAAATATTCAATATCGggcaaaagaagaaaaagacaGCACCCACAGAGAAACCTCTTAAGCCTGTAAAGGAGAGAAAGAAACCAAGACCCTATAAtcgtaaaattaaaaaggaaaaaGATGTACCAAAAAGTGTGCCAGAAGCAGTAGCTTCAATAATTGGTACTGTTGAGCAAAATGAGGCTGCTGGTAAAACAGTCTGCCAAGAATCAAAGACATTGGATAACACAAAAGAAAATGTACAACTAGTCAATAAGGACGAGCCTGCAAGTAAAAACGAGGATATAGGAGATGACCTGCCTGAACAGGACAGTTCTGATCTTTCTGACGCGCTCACTACTGAAAATAATGTGACAGTGGAAACTGTTAGTGAAGAAGAAgcaaaactagtgaaatttgaTAAACCTGATGAGCAAAGACACGAAGAGGTAATTGATAAGATCAAAGAAGCGATCAATAAACTAGAAGACGGTTTAACGGAAGTTAAAACAGTCCATTCTCCGAAGCCTGAATTAAAACTTGAAATTACCAAACTAGTTGTCAAGGATGAAAATTTGAAACAGGAAGTCATAAAAGAAGAAACTGTAAAGGAAGAGGTGGTAATCAAAGAAGAACCTAATGAAGTGAATACAGAAGAAACTATAAAAGCAAATACAGGCAAAACAGTTAAAacatcaataaaaaaatctgaagATGTGAAAGTAGAATCTAAAGTCGTCAAAGAAGAATCAGATGACAAACCAAAGAAGAAACTATCGAAAATAAAGAAGAATAAAAAATTGAGATTATTACAAGAAAAGAAGGTAAAGAAACAAGTAGAAAAAGTTAAGAACGAGTTGCAAGATATGAAGAGACAGATTGAGGAAATGCGACTGCAGATGCTGAAGAAGACAGAGGAACTAGCGGTCAAAAATCAGGAGATGCCGGAAAGTTTCCTGTTGCCCGGAGAGTGGTGTTGCAAGTGGGTAAACGGACAACCGGTGGGGACTGTCAGTGAGATGGAAAGTGAGACACCGGTGGATAGTAATAATAAGCCTGGCTTGCCGCGACGAAGTGTACAGGTGGAAGATAAAAGGTTGCCAGAAGGTTGGACAAAACACATGGTGAGAAGAAGCCTCGGACAGTCTGCTGGTAAATGGGATGTGGTTTTAGTGGGcccCGACAACAGACGGTTTCATACAAAAACAGATATGCGCAATTTTATTGAACTCCACAGCGATTCACTTAGGGTATATGAAAATGCGCTTCTCGATTTCGGGGTTCACCTCAAACTGGCTAGACGTATGGGCTGGTATAAGATGACCGGCGAAGATACGCCTCCGCCTACTGCCGCCATCACTAGCATGTCACCTCTAGTCAAAAGAAAGAGTATACTGAAAAAAGAAAGGAAAGAAAAGAAGAGAAAGTTAAAGATTaaATTCAAAAAATCTGCTTCAGCATACAGTATTGCAGCAGAAGATGACCCAACAGAAAATCCACCAGAATCAACAGATATGTCGCTTTATAATACAGAGTTGGAAGATGGCTATGTGTTTGTCGGTTCCTTGAAAGTCCAAGTAGTTGATAACTTACTTCGCTGTCCTGCGGAAGGTTGTTTCAAAGCATTCAGAAATAATACCCTCATAAAAATGCATATAAAACATTACCATAGGGATCTCCGGAAAATGCTCGGCGTAACGCCGAAAGTTCTGGACTTGGCCTACGCTCGAACCAAGTCAGTTAGTAAGGAACatcaaaagaaaaaacaagtGCTAAAAGCTAAAAGTCTCAAAGTGAAATTGCCGAAACATAAGCGGCCGCAGGAGCCGCAATTAGAAGTACAGAGCACGTTGTCGCTCGAACCAAAAGAAGACATTTCAAAACCACCGAGGTTGATTCCTAGGTCTCTAGACTCGCCCAAACTACGTCAAAGTCTCCAACAAGTGAATAAACCGGTGAAACGACCCAAAGTACTGCTGCCTGTTAGAAGACCGGAGCCAGAGGTCCCCAAAGACGAGACGGTGGTTGAATTCGATGATGTGAAAATAACAATGCCGGACATACCTAGACAGTTAGACTTTGAAGAAGCCATAACTACACACACGGTAACCAAACCAGCGGATTTGATTAAAGAGAAAAAAACCACAAGGATGGAGGAGGATGATTGGTTTGCTGCTTCAGATTTTGACACCAACAGTTGTCCAGGGTCAGCAACTCCGGACTCCAAGGTCATGGACAAACCAGCCGATATCACTGATCAGACTGCATATGACAATGTAGAGGATAAGGACGCGAATATGTACATGTATACCGAAACGGGCGAGCGCATCAAGTTGGAGCGCATGAAACGCGAGGAGATCATCAACTGCCACTGCGGCTTTCGCGAGGAGGACGGGCTGATGGTGCAGTGCGAGCTGTGCCTGTGCTGGCAGCACGCGCTCTGCCACAACATACAGCGCGAGGCCGAGGTGCCGGAGAAGTACACGTGCAGCATCTGCTTAAACCCAAAGCGGGGGCGGCGCTCGGCGCGCTTCCTGCACGACCAGGACCGGCTGTACGAGGGCCTGCTGCCGGGCGCGCGCGCCTCCGAAAGCCTGCGCCGCTCGCACGAGCTCTCCGGTAACCTGCTGCGCGTGCAGGACGCGCTGCACGCGCTCCGCGTCAAGTACTACGTCGCCACTAAGAAGAACCATCCCAAACTCTACTTGTGGGCGAAGGATTGGGAGGCGGCCGAGATCTCTATGACGCAAGAGAAACTCAACTCGGATTACTCGGATCTGAACATCATAATAAACAACATCGGCAAGGAGAATCTACCTGTGAAAGCGGACGACATGAAAGATTTGCACCTCGACCTCCGCACGCTACCTGACGATGATCACAAGGACTCTCTTTTGAGTCTGGCCAATGCCCTCTCTAGTCCTGGCGGGACGTCCCTGGACCTGCCAATCAGTACGTCCGATCTGGAACGCCTGGCCAAAAGTGTTCAAGAGCAAGAGAGCCCCCGGCGTATGATCGTGCCGCAGCCCGAGGCGGCGATCGACAACAACGTGTGCCGCGAGCGCCTGCTGCGTCACCTCACACGCTGCCAGGCGCTCATCGACGCGCGGCTCGACTCCATCGAGGCGCAGGTCGCGGAGTTGGAATCACAAGACCCATCGTTTGAAGACGACGAAACAGCTGACTACTTCCCCAGGACAAAGCAGACCATACAGATGCTCATGCGAGACCTAGACACTATGGAGGAGTTGGGGATTATCACATAG
Protein Sequence: MLIKTCCVEKCPSSASRSEDVGVTFHKFPKDFKLRKSWLEVTHHKPCSNVPSFVCSRHFCKNDFKAYQDSKYILKADSIPSIFSWTTKMADIEHIVKETEGNQNTSSSNKEPEENVDTIMKFMEEQDKEKVEKNQSNVYSSDSQVLEAIYPKADVKSASCVLDMLMSETNKIAYKKDTKPSPKPITTSGEKGSVALSIGSKVEARDYANVWNAAEILEVDCDEMEVLVHYDSLANKPDEWISVSSSRLRPVSAKPIAPPQSTPVSHITENIIKEEMPDDRDKIKPTFGVGERCLARWKDNRRFVATISKELENGSYEIIFDDGFTWKCSALRLYKLKDSGKISDNLSIDTSVHPTATPTHSPILEGVGPSTGTALKPSALPPFHTHLFDPTRDYLGSKKERRDMKRKLNIKEIFNIGQKKKKTAPTEKPLKPVKERKKPRPYNRKIKKEKDVPKSVPEAVASIIGTVEQNEAAGKTVCQESKTLDNTKENVQLVNKDEPASKNEDIGDDLPEQDSSDLSDALTTENNVTVETVSEEEAKLVKFDKPDEQRHEEVIDKIKEAINKLEDGLTEVKTVHSPKPELKLEITKLVVKDENLKQEVIKEETVKEEVVIKEEPNEVNTEETIKANTGKTVKTSIKKSEDVKVESKVVKEESDDKPKKKLSKIKKNKKLRLLQEKKVKKQVEKVKNELQDMKRQIEEMRLQMLKKTEELAVKNQEMPESFLLPGEWCCKWVNGQPVGTVSEMESETPVDSNNKPGLPRRSVQVEDKRLPEGWTKHMVRRSLGQSAGKWDVVLVGPDNRRFHTKTDMRNFIELHSDSLRVYENALLDFGVHLKLARRMGWYKMTGEDTPPPTAAITSMSPLVKRKSILKKERKEKKRKLKIKFKKSASAYSIAAEDDPTENPPESTDMSLYNTELEDGYVFVGSLKVQVVDNLLRCPAEGCFKAFRNNTLIKMHIKHYHRDLRKMLGVTPKVLDLAYARTKSVSKEHQKKKQVLKAKSLKVKLPKHKRPQEPQLEVQSTLSLEPKEDISKPPRLIPRSLDSPKLRQSLQQVNKPVKRPKVLLPVRRPEPEVPKDETVVEFDDVKITMPDIPRQLDFEEAITTHTVTKPADLIKEKKTTRMEEDDWFAASDFDTNSCPGSATPDSKVMDKPADITDQTAYDNVEDKDANMYMYTETGERIKLERMKREEIINCHCGFREEDGLMVQCELCLCWQHALCHNIQREAEVPEKYTCSICLNPKRGRRSARFLHDQDRLYEGLLPGARASESLRRSHELSGNLLRVQDALHALRVKYYVATKKNHPKLYLWAKDWEAAEISMTQEKLNSDYSDLNIIINNIGKENLPVKADDMKDLHLDLRTLPDDDHKDSLLSLANALSSPGGTSLDLPISTSDLERLAKSVQEQESPRRMIVPQPEAAIDNNVCRERLLRHLTRCQALIDARLDSIEAQVAELESQDPSFEDDETADYFPRTKQTIQMLMRDLDTMEELGIIT*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00403828;
90% Identity: iTF_01178644;
80% Identity: iTF_00744724;