Ahon005950.1
Basic Information
- Insect
- Adoxophyes honmai
- Gene Symbol
- PAX6
- Assembly
- GCA_005406045.1
- Location
- BHDV01000368.1:180932-191620[+]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 2.3e-69 6.8e-66 220.1 0.3 1 117 31 147 31 154 0.98
Sequence Information
- Coding Sequence
- ATGCTGCCGGCGCAGCAGCTGCCGCCCATCAGCCCGTGGCCTCCGGACGCCGTGCTGGACCGCATGGACGACCTCGCGCACAAAGGTAAAGGTCACAGCGGTGTTAACCAGCTCGGCGGCGTGTTTGTAGGAGGCAGACCTTTACCCGACTCCACGCGGCAGAAGATCGTGGAGCTGGCGCACTCGGGAGCCCGGCCGTGCGACATCAGCCGCATCCTGCAGGTCTCCAACGGCTGCGTCAGCAAAATCCTGGGCAGGTACTACGAGACGGGATCGATACGACCGCGGGCCATCGGTGGCTCGAAGCCCCGAGTGGCCACGGCTGAGGTGGTCAGCAAGATAGCCCAGTACAAGCGGGAGTGCCCCTCGATCTTCGCCTGGGAGATCAGGGATCGTCTGCTCAGCGAGGGCGTGTGCACCTCGGACAACATCCCAAGCAGATTCGGATCTCACAGGGGTAGGAGAAAACAAATTGTAACAAAGGAGTCCGGCAAAGAAGATTATCGGCGATGGCGCGTGGCGGACGCGTGGCGCGAGTGTGGCCCGTGA
- Protein Sequence
- MLPAQQLPPISPWPPDAVLDRMDDLAHKGKGHSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTSDNIPSRFGSHRGRRKQIVTKESGKEDYRRWRVADAWRECGP
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00390339;
- 90% Identity
- iTF_01134759; iTF_01135721; iTF_01544846; iTF_01542936; iTF_01546616; iTF_00358531; iTF_00796481; iTF_00213413; iTF_01080684; iTF_01079026; iTF_00247155; iTF_00432121; iTF_00780218; iTF_00695515; iTF_00781791; iTF_00954431; iTF_00457199; iTF_00777972; iTF_00778722; iTF_00775987; iTF_01021175; iTF_01017696; iTF_01508032; iTF_01091882; iTF_01401263; iTF_00715758; iTF_00772848; iTF_00409248; iTF_00156212; iTF_00159805; iTF_00723030; iTF_01561087; iTF_01464128;
- 80% Identity
- -