Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_036417725.1
Location
CM071151.1:15367917-15384432[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 4.9 1.8e+04 -4.1 0.0 33 48 452 467 450 468 0.83
2 2 2.3e-15 8.7e-12 45.0 0.0 5 61 788 843 784 901 0.90

Sequence Information

Coding Sequence
ATGGCCGTAAAACATTGTTGCATAGACACATGTAAATCCTGCTCAACAAGAAAGGAAGACAATGGTGTCACATACCACAGATTTCCAAAAGATCCAGTTTTACGTAACACCTGGATGTCTTTAACTTGTTGCAATAATTTAGACTTGCCGAACTATGTGTGCTCGAGACATTTCtgtaaaaatgattttcaaCCATATAAGGACTCTAAATACATACTAAAGTCAGATGCAGTACCTTCAATTTTTCCATGGACAATGTCTGATGTAACTAGTAACACTGAGATGGAAACTGGAGATACCAAATCCGATGATGATGTTTTAGATccaccagaaacaaaaaatgaattaaataccTCAGGTAGTAGTAAGGAGTCTGATGAAAATGTGGATGCTATAAGAAAATTTATTGAAGATCAAGATAAAGAATTTCGTGACAAAAATGATTCTGAAAATATTACAGAGGATGTTCAAACAGAGATAAACAGCAACAATGTAGGTGACAATGAAAATGATGAAAGTGCAGCTAAAGATCTACAAATTGATAATGTCGAAATTGCcagtaaaaatgtaaataataacaatgatgaAAGTGCCAGCAAAGATATCAATAATGACACTGATGAGGCTGTTAGTAATGATTTTGCTAAAAATGACAATGAAGGCACAATTGTTGTTGCTACCAGTGTTATGAATATGATACTAGATGAATCAGAGGTGAAAATAGAAAATAAGAAAGACTCAACACCAGTTTCTAAGTATAGTTTGACTCCGGATAAAGCTGTCAGTGGCAGTATTTCTCTCTCAGTTGGTTCAAAAATTGAAGCCAAAGATTTCGGCGACGAATGGCATCCGGCGCAGATCGTGGAGGTCGATTATGAAGAAATGGAAGTATTGGTCCATTATGAACCACACAACAAgagACATGATGAATGGATCAGCGTGAGCAGTCCACGGTTACGACCAATAACAGACACTCCTAAATGTGAAACAAATGTAGCAGAAAAGATGCCAGAACAGACTGCACCAGTCAAAGAAGAAATTAAAGAAGTAAAGGTAGAAGAGAAACCGAAAATAACTTTCGCAGTTGGAGAAAGATGTCTGGCTCGTTGGAGGGATAATAGGAGGTTTATAGCTACCATACATAATGATTTGGGAAATGGTACCTATGAAATAATATTCGACGATGGTTTTCAATGGAAGTGCAGTGTATCAAGGCTTTATAAGTGGAAACCGACGGGAAAGCAAGATCTTCTGACAGTAGACACATCCTTACAGTCTACTACGGGAGCCCCATCTCCGATACAAGTTGGTGGCCCAAGCACTGCAGGCCCGCTTAACCAACCAGCTTTTCACACTCATTTATTTGATCCCACACGAGATTACCTAAGTTCTAAAAGTGAACGTCGTGAaatgaaaagaaaattaaacatTAAAGAGATATTTAATATTGGACAAAAGAGACAGAAAACAAAAACTGATACCATTGTCAGGAAGCCAAGGATTATAAGAAGGACCCCTAAAGTTAAAATTGAACCGTATTTCAAAAAGGAACTGAAAGTTCAACTTAAAAGGGAGATACCTGATGCTGTTGCTTCTATTATTGGTACGGTAAGTAAAGAGGAGCCTGGGATAACAGAAATAGGAAGCGAAGATATTATCGAAGTTAAACTAGAAGAGATAGATAAGGATGACAATGAAATTACGGATGTTAAAGAACTAGAAAGTGCTGACACACAGGTAGCGGATGATTTTAAAATGGATCCATTTAAAGCAGAACTAGACCCTGTACACGAAGAAGATGTAAAACTTGAAAAATTTGATAAGCAAGATGACGGTAAGCACGAAGAAGTAATTGATAGGATTAAGGAGGTAATAAACAAGCTAGAAGGTGGGTTAACTGATGAGAAGTTAAATTCTCCTAAAATAGAAATCAAAGAAGAAATACCAATTCTTAACGAAATTGACCCTGTAGATGCAAAAGAAGAATCAGGCGTGGACGTTGTTGTAGATGCCAAAGCAGAAGCAACTATTGtaccaaaaacaaaattaaaaaaattatcaaagaTAAAGAAAAGTAAGAAACTAAGAATGTTGCAGGAGAAAAAGGTAAAGAAACAAGTTGAAAAGGTGAAAAACGAACTGGAAGAGATGAAAAGGCAAGTGGAAGAGATGAGAAAGCAGATGTTGCTGAAAACGCAAGAGCTTGCGAAGGGGCAATCCGAGATGCCAGAAAGCTTTCTGTTGCCCGGAGAATGGTGCTGTCGTTGGTTAAACGGACAGCCTGTTGGAACTGTCAGTGAAATTGTATGCGAGGTTAAAGTTCATGGAGATGGGAAACCAGGATTGCCGCGGCGAAGTGTACaggtgGAAGATAAGCGGTTACCTCCAGGGTGGACGAAACACATGGTGCGAAGGAGTTTGGGACATTCAGCTGGGAAGTGGGATGTTGTGCTTGTTAGCCCAGAAAACCGTCGTTTCCACACTAAAACAGACATGCGTAATTACTTAGAAAACAGTCCCGATGAATCTATTAAGCAGTACGAAGGGGCTTTGATGGATTTCGGTGTGCATTTAAAGTTGGCCCGGCGTATGGGGTGGATCACGACTACTCCGGGAGGAGTAGCAGATGGGCCTTCGTTACCATGTGGCACCTTACATAGCACCTCACCTTTGGTTAAGAGGAAGAAATTAAACCTTAAAAAGTCTGAAAAGAAGAGCGGGGAGAAGAAAAATCgagacaagaaaaacagagATAAAAAGAAGAAATCTTTGCGGATGAAGTTGGCTATGGCTTCTCAGAATATTGTTGACGGGACAATGAATATGTATACCACTTCTGATACGGTGCAGACGCCAGAACCTGTCCTCGACACTTTGACATTAGAAGATGGTTACGTGTATGTTGGTTCCCTCAAAGTACAAATAATAGAGAATCTCCTCCGATGTCCAGCCGAAGGTTGTTTCAAAAATTTTCGAAATAATACACTTTTACAAATGCATATCAAACATTACCATCGTGAATTGAGAGGAAAGTTAGGCGACACACCGAAAGTTCTAGACTTGGCATATGCGAGAACTATGCCATTGCTGCCTGATACGCCTAGACAAGTGGATTCTAAAGTTATAAAGGTGAAAATACCAAGGCCGAAACGTGAAGAGCCGAAACTTGAACCCATTGACGTTAAACCTGATTTGCTTATTGATACTGAACCTAAAACGCCACTTGGTCAAGACAACGATAGTAATCCGAAGACACAAGACTCGCCCAAGTTGCGGGATGCTTTGGTCAACAAGCCAGTGAAAAGACCAAAGGTTTTACTGCCAGTTAGGAGACCGGAGTTTGATCCAGAACCATCTATTGTGGAGGATTATGGTGAATTGGCAGAAATACCAGTTGGTGACTGTTTGATTGAAGCATTAGATTTTGAAACTGCAATTTCAACTCATACTGTGACTAAGCCGATTTCTGAAAAGCCAAGAAAAGGCGAGAGGCAGCCAATATCTTCAACAGTGATGTCACAGAAGGCGAGTGAAGATGAGGAATGGTACGTAAATTCTGATTACGAGACGAGATCTAGTTTCCCACGATCTGGCTCGCCGGACTCGAAGTCTGCTGAGATGCAGTTGGTCAAGACAGAGGATTTTACGCCAGAGTCCAATGAAGAACAAAAAGAGTCACAGAAGTATACATACACCGAAAACGGCGAGCGAGTGAAGATAGTGCACATGAAGCGAGAGGAGATCATCAACTGCCACTGTGGGTTCCGTGAGGAGGACGGGCTCATGGTGCAGTGCGAGCTCTGTCTGTGTTGGCAGCACGCGCTCTGCCACAACATACAGAGCGAGGCGCAGGTGCCGGAGAAGTACACGTGCAGCATCTGCCTGAACCCGCGGCGCGGGCGTCGCTCGGCGCGGTTCGTGCACGACCAGGACCGGCTGTACGAGGGCGTGCTGCCGGGCGCGCGCGCCTGCGACCTGCTGCGCCGCTCGCACGAGCTCTCCGGGAACTTGCTGCGCATGAGCGACGCGCTGCACGCGCTCAGGGTCAAGTGCTTCGTCGCCGCTAAAAAAGACCATCCAAAGCTGTACCTATGGGCGAAAGATTGGGAGCATGCAGAGATATCGTACACTCAAGAGAAACTGAACTCTGACTACTCTGACCTGAACATAATGATCAACACCGTGGGGAAGGAGAACATGCCGATGAAACCTGAGGATATGAAGGACATGCAGCTCGGCCTGTCATCTGACGATACCGATCTTGATAGGTTTTCGCATAGAGATAATCAACTGAGTTCGAACGCGCTGTTGAACAACTTGCTGTCCAGTCCAGGCGGGGCGTCCCTCGACCTGCCTATAAGTACCTCAGAGCTGGAGACCCTCGCGAAATCAGTTCAAGAGCAAGAGTGTTCTGTGCCCGGAGTGGGGGTGGGTGTGGGGGTGGGAGTCGGAGTCGGAGTCGGAGTGGTCGTCCCCGCGCCGCAGCCCGAGGCGGCGATCGAGAACGGCGCGTGTCGCGTGCGGCTGGTGCGGCACCTGCAGCGGTGCCACGCGCTGCTCGACGCGAGGCTCGACTCCATCGAGGCGCAGGTCGCAGAATTAGAGTCCCAAGACCCATCGTTCGAAGATGACGAGACGCCCGATTTCATCCCGCGAACTAAACAAACGGTGCAGATGCTATTACGAGACCTTGATACTATGGAAGAGTTGGGGACTATTACATAA
Protein Sequence
MAVKHCCIDTCKSCSTRKEDNGVTYHRFPKDPVLRNTWMSLTCCNNLDLPNYVCSRHFCKNDFQPYKDSKYILKSDAVPSIFPWTMSDVTSNTEMETGDTKSDDDVLDPPETKNELNTSGSSKESDENVDAIRKFIEDQDKEFRDKNDSENITEDVQTEINSNNVGDNENDESAAKDLQIDNVEIASKNVNNNNDESASKDINNDTDEAVSNDFAKNDNEGTIVVATSVMNMILDESEVKIENKKDSTPVSKYSLTPDKAVSGSISLSVGSKIEAKDFGDEWHPAQIVEVDYEEMEVLVHYEPHNKRHDEWISVSSPRLRPITDTPKCETNVAEKMPEQTAPVKEEIKEVKVEEKPKITFAVGERCLARWRDNRRFIATIHNDLGNGTYEIIFDDGFQWKCSVSRLYKWKPTGKQDLLTVDTSLQSTTGAPSPIQVGGPSTAGPLNQPAFHTHLFDPTRDYLSSKSERREMKRKLNIKEIFNIGQKRQKTKTDTIVRKPRIIRRTPKVKIEPYFKKELKVQLKREIPDAVASIIGTVSKEEPGITEIGSEDIIEVKLEEIDKDDNEITDVKELESADTQVADDFKMDPFKAELDPVHEEDVKLEKFDKQDDGKHEEVIDRIKEVINKLEGGLTDEKLNSPKIEIKEEIPILNEIDPVDAKEESGVDVVVDAKAEATIVPKTKLKKLSKIKKSKKLRMLQEKKVKKQVEKVKNELEEMKRQVEEMRKQMLLKTQELAKGQSEMPESFLLPGEWCCRWLNGQPVGTVSEIVCEVKVHGDGKPGLPRRSVQVEDKRLPPGWTKHMVRRSLGHSAGKWDVVLVSPENRRFHTKTDMRNYLENSPDESIKQYEGALMDFGVHLKLARRMGWITTTPGGVADGPSLPCGTLHSTSPLVKRKKLNLKKSEKKSGEKKNRDKKNRDKKKKSLRMKLAMASQNIVDGTMNMYTTSDTVQTPEPVLDTLTLEDGYVYVGSLKVQIIENLLRCPAEGCFKNFRNNTLLQMHIKHYHRELRGKLGDTPKVLDLAYARTMPLLPDTPRQVDSKVIKVKIPRPKREEPKLEPIDVKPDLLIDTEPKTPLGQDNDSNPKTQDSPKLRDALVNKPVKRPKVLLPVRRPEFDPEPSIVEDYGELAEIPVGDCLIEALDFETAISTHTVTKPISEKPRKGERQPISSTVMSQKASEDEEWYVNSDYETRSSFPRSGSPDSKSAEMQLVKTEDFTPESNEEQKESQKYTYTENGERVKIVHMKREEIINCHCGFREEDGLMVQCELCLCWQHALCHNIQSEAQVPEKYTCSICLNPRRGRRSARFVHDQDRLYEGVLPGARACDLLRRSHELSGNLLRMSDALHALRVKCFVAAKKDHPKLYLWAKDWEHAEISYTQEKLNSDYSDLNIMINTVGKENMPMKPEDMKDMQLGLSSDDTDLDRFSHRDNQLSSNALLNNLLSSPGGASLDLPISTSELETLAKSVQEQECSVPGVGVGVGVGVGVGVGVVVPAPQPEAAIENGACRVRLVRHLQRCHALLDARLDSIEAQVAELESQDPSFEDDETPDFIPRTKQTVQMLLRDLDTMEELGTIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2