Mtil007955.1
Basic Information
- Insect
- Mimas tiliae
- Gene Symbol
- MBD-R2
- Assembly
- GCA_905332985.1
- Location
- HG995242.1:15232449-15248936[+]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 3.5 1.7e+04 -4.1 0.0 33 48 470 485 468 486 0.83 2 2 7.6e-17 3.6e-13 49.3 0.0 5 63 804 861 800 890 0.90
Sequence Information
- Coding Sequence
- ATGGCTGTAAAATACTGTTGCGTTCAAACGTGTAAATCCTGCTCAACGAGAAAAGAGGACAAAGGTGTCACATACCACAGATTTCCAAAAGATCTGGTTTTACGTAAAACATGGATGTCAAAAACTTTATGCAAAAATTTCGACTTGCCAAAGTATGTGTGTTCGAGACATTTCTGTAAAAATGACTTTCAAATGTATAAGGACTCTAAGTACATACTGAAGTCAGATGCAGTGCCCTCAATTTTTCCATGGACAAAATCTGATATAACTGACACCATCAAGATGGAAACTGTAGACACTAAATTAGAAGATAATACTTCAAACCCACAGGAGATGCAAAGAGACTTAAATATCTCAGATAGTAGTAGTAAAGAGTCTGAAGAAAATCTGGATGCAATAAAAAAATTCATTGAAGATCAAGACAAAGAATTGCAAGAGAAAGATGTTGCTGTTAATGGTACTGAGAATGTTCAAACTGAAACCAACAGTAACATTGTTCCAAATAATGACAATGATGAAAGTGCTAGTAATGATATAAGTGTCAATGAAGAAAATATTGGTAAAGATGACAATAATGAAAATACTAGTATGGATGTAAATAATGACAATACTGAAAATGCCAGTAATAATGGAAATAATGACAATGCTGAAAATGAAAGTAATGATGTAAATAATCACAATAATGAAAGTAATGATGTTTCAAATAATGCCAATGAAGGGACGGTGGTGGTTGGTACCAGTGTTATGGATATGATATTGGATGAATCAGAGTCGAAAATAGACGACAAAAAGAACTTAACAGTGACTAAGTATAACTTAAGTCCTGATAAAGTTGCCAGTGGCAGCATTTCTCTATCAGTCGGTTCAAGAATAGAAGCCAAAGATTTTGGTGATGAATGGCATCCGGCGCAGATAGTAGAAGTCGATTATGATGAGATGGAAGTCCTGGTCCGTTATGAACCATACAACAAGAGACATGACGAATGGATCAACGTGAGTAGTCCACGCTTACGACCAACAACCGGCGATACTAAACTTGAAACAAATGTAACAGACAAGATGCCTGAACAAAAGGCACCAGTTAAGGAAGAAATCAAAGAAGTAAAGGTAGAAGAGAAGGTCAAATTAAGCTTCGCTGTGGGAGAGAGATGTTTGGCTCGTTGGAGGGATAATAGGAGGTTTATTGCTACGATACAAAATGATTTGGGTGATGGTACATATGAAATAATTTTCGATGATGGTTTTCATTGGAAATGTAACGTATCGAGGCTTTATAAGTGGAAACCGACGGGAAAGCAAGATGTTCTTACCGTAGATACATCCTTACATTCGCCAACCGGAGCCCCGTCTCCCATACAAGTTGGTGGTCCAAGTACTTCAGTCCACCCTACCACGACAGTTTTCCACACGCATTTATTTGACCCCACACGAGATTACCTAAGTTCTAAAAGTGAACGACGTGAAATGAAAAGGAAATTGAATATAAAAGAGATATTTAATATTGGACAAAAGAGGCAAAAAACGAAATCGGATAAAGTCGTGAGAAAGCCAAGAATCATAAGGCGCACTCCTAAAGTTAAAATAGAACCTATAATTAAAAAGGAACTGAAGGTTGAACTTAAAAGGGAGATACCAGATGCTGTTGCTTCTATCATTGGTATGGTTAATAAAGAAGAGCCTGCGATAACAGAAATTACGAGTGAAGATATTATCGAAGTTAAATTAGAAGAAATAGACAAGGATGATATTGAAATCACAGATGTGAAAGCGCCTGAAATTGCTAACACACAGGTAGCGGATAGTTTTAAAATGGATCCGTTTAAAGCAGAAATAGACCCTGTACACGAAGAAGATGTGAAACTTGAAAAATTTGATAAACAAGATGACGGTAAGCATGAAGAAGTAATCGATAGAATTAAAGAAGTAATTAACAAACTGGAGGGCGGTTTGAATGAGGAAAAGGTGAATTCTCCCAAAATAGAAACGAAAGAAGAAATTTCTAATAAAGTTGAATCGGTAGATGATAAACAAGAACCAGAAGAAAACGTAGTGGTAGACGTCAACGCAGTCGCAACTACTGCACCAAAAATAAAATCCAAAACACTATCAAAGATAAAGAAAGGTAAAAAGCTGAGAATGTTACAGGAGAAAAAGGTGAAGAAACAAGTTCAGAAAGTGAAAAATGAACTTGAAGAAATGAAGAGGCAAGTGGAAGAGATGCGAAAGCAGATGTTGTTGAAAACGCAAGAGCTTTCGAAGGGACAAGCAGAGATGCCGGATAGCTTTCTGTTGCCTGGTGAATGGTGTTGTCGGTGGTTGAACGGACAACCTGTAGGAACGGTCAGCGAGATTGTGTGCGAGTCTAAAGCCGATGGAGACGGGAAACTGGGATTGCCGCGGCGTAGCGTTCAGGTCGAAGATAAGCGGTTACCTGCAGGCTGGACGAAACACATGGTACGAAGGAGCTTGGGACATTCAGCCGGAAAGTGGGATGTTGTGCTTGTTAGCCCTACAAACCGCCGTTTCCATACAAAAACGGACATGCGTAATTACTTAGAAAATAATCCTGATGAATCGCTAAAGCAGTACGAAGCGGCGTTGATGGATTTCGGGGTGCATTTAAAGTTGGCCCGGCGTATGGGGTGGATCACGACGACTCCGGGTGGGATGGCGGATGGGCCATCGTTACCATGTGGCACTTTGCACAGTACCTCGCCTTTGGTTAAGAAAAAGAAGTTAAATCTTAAAAAACCGGAAAAGAAAGTTCGGGTGAAGAAAAGCAGGGACAAGAAGAAGAAAATTTCTTTTAGGATAAAATTGGCTTTGCCTTCTCAGAATGCTGTTGATGAGACCGTAATTATGGATAGTTACAATTCTGTTGCGACGACCGAACCTGCGCTTGACACTCTGGCTTTAGAAGATGGTTATGTGTACGTCGGATCCCTTAAAGTTCAAATAATAGAGAATCTTCTGCGATGTCCAGCCGACGGTTGCTTTAAGAATTTTCGAAACAACACGCTATTGCAAATGCATATCAAACATTACCATCGAGAGTTGAGAGAAAAGTTAGGTGACACCCCTAAAGTTCTAGACCTGGCATATGCCAGAACTATGCCACTGGTGCCTGACCCGCCTCGACAAGTAGATTCTAAAGTAATAAAGGTCAAATTACCAAAGCCGAAGCGGGAAGAGCCTAAACTTGAACCTATTGATATTAATTCAGATATACTAATTGATACTGGACCTAAAACACCACTTAGCCAAGATGATGATAGTGTTCCAAAGACACAAGATTCACCTAAATTGCGTGATGCGTTGATTACCAAGCCAGTGAAAAGACCAAAGGTTTTACTTCCCGTTAGGAGACCGGAGTTCGACCCAGAACCAACTAATGTAGACGATTATGAAGAATTTCCAGAAATGCCATGCGATGACAGTACGGTAGAGCCATTAGATTTTGAAACTGCAATCTCAACTCATACTGTGACTAAGCCTATTTGTGAAAAGGGAAAGAAAGGCGAGAAAAAGCGAAAATCAATAACAATAATGTCGCAGAAGGCGAGTGAAGACGAAGAATGGTACGGGAACTCTGATTTTGAGACGCAGTCCAGTTTCCCGCGGTCTGGCTCGCCGGACCAGTCAGCGGAGATGCAAATAATTAAGTCAAGAGCTTTAACGCCGGAGTCTGCTGAAGAGCACAAGGAGACGCAGAAGTACACGTATACGGAGAATGGCGAACGTGTAAAAATAGTGCATATGAAGCGAGAGGAGATCATCAATTGCCACTGCGGGTTCCGTGAGGAGGACGGGCTCATGGTGCAGTGCGAGCTGTGTCTGTGTTGGCAGCATGCGCTCTGCCATAACATACAGAGCGAGGCACAGGTGCCAGAGAAGTACACATGCAGTATATGCCTGAATCCCCGTCGCGGTCGTAGATCTCAGCGGTTCCTGCACGATCAGGATCGTCTGTATGAAGGGTTGCTGCCGGGCGCCAAGCCGTGCGATCTGTTGCGACGTTCACACGAACTGTCCGGCAATCTGTTGCGGATACAGGACGCGTTGCACGCGCTCAGGGTCAAGTGCTTTGTGGCCTCTAAAAAAGACCATCCAAAATTGTACCTATGGGCCAAAGACTGGGAGCAAGCTGAGATATCTTACACTCAAGAGAAACTCAACTCTGACTACTCAGACCTGAACATAATGATCAACACAGTGGGCAAGGAGAATATGCCGATTAAGCCTGAGGACATGAAGGACATGCAGCTCGGATTGTCGTCTGATGATGCCGATATTGACAGGTTTTCGCAGAGAGATAATCAACTAAGCTCTAACGTGTTGTTGAACAACTTGTTGTCAAGTCCGGGCGGTGCCTCACTCGACCTGCCCATAAGTACCTCGGAGTTGGAGACGCTGGCCAAATCTGTTCAAGAGCAAGAATGTGGTGTGGCGGGCGTAGAGGTGGATGTGGGTGTAGATGTGGGCGTGGGCGCGATGATGTCCGTGCCGTCTGTATGCGCGCCGCAGCCCGAGGCGGCCATCGAGAACGGAGCGTGTCGCGTGCGTCTGCTGCGCCATCTGCAGCGATGCCACGCGCTCGTCGACGCCAGGCTCGACTCCATCGAGGCGCAAGTCGCAGAATTGGAGTCACAAGACCCATCATTCGAAGACGACGAGACGCCCGACTTCTTCCCGCGAACTAAGCAGACAGTACAAATGCTGTTACGAGATCTGGATACTATGGAGGAGTTGGGGAGCATTACATAA
- Protein Sequence
- MAVKYCCVQTCKSCSTRKEDKGVTYHRFPKDLVLRKTWMSKTLCKNFDLPKYVCSRHFCKNDFQMYKDSKYILKSDAVPSIFPWTKSDITDTIKMETVDTKLEDNTSNPQEMQRDLNISDSSSKESEENLDAIKKFIEDQDKELQEKDVAVNGTENVQTETNSNIVPNNDNDESASNDISVNEENIGKDDNNENTSMDVNNDNTENASNNGNNDNAENESNDVNNHNNESNDVSNNANEGTVVVGTSVMDMILDESESKIDDKKNLTVTKYNLSPDKVASGSISLSVGSRIEAKDFGDEWHPAQIVEVDYDEMEVLVRYEPYNKRHDEWINVSSPRLRPTTGDTKLETNVTDKMPEQKAPVKEEIKEVKVEEKVKLSFAVGERCLARWRDNRRFIATIQNDLGDGTYEIIFDDGFHWKCNVSRLYKWKPTGKQDVLTVDTSLHSPTGAPSPIQVGGPSTSVHPTTTVFHTHLFDPTRDYLSSKSERREMKRKLNIKEIFNIGQKRQKTKSDKVVRKPRIIRRTPKVKIEPIIKKELKVELKREIPDAVASIIGMVNKEEPAITEITSEDIIEVKLEEIDKDDIEITDVKAPEIANTQVADSFKMDPFKAEIDPVHEEDVKLEKFDKQDDGKHEEVIDRIKEVINKLEGGLNEEKVNSPKIETKEEISNKVESVDDKQEPEENVVVDVNAVATTAPKIKSKTLSKIKKGKKLRMLQEKKVKKQVQKVKNELEEMKRQVEEMRKQMLLKTQELSKGQAEMPDSFLLPGEWCCRWLNGQPVGTVSEIVCESKADGDGKLGLPRRSVQVEDKRLPAGWTKHMVRRSLGHSAGKWDVVLVSPTNRRFHTKTDMRNYLENNPDESLKQYEAALMDFGVHLKLARRMGWITTTPGGMADGPSLPCGTLHSTSPLVKKKKLNLKKPEKKVRVKKSRDKKKKISFRIKLALPSQNAVDETVIMDSYNSVATTEPALDTLALEDGYVYVGSLKVQIIENLLRCPADGCFKNFRNNTLLQMHIKHYHRELREKLGDTPKVLDLAYARTMPLVPDPPRQVDSKVIKVKLPKPKREEPKLEPIDINSDILIDTGPKTPLSQDDDSVPKTQDSPKLRDALITKPVKRPKVLLPVRRPEFDPEPTNVDDYEEFPEMPCDDSTVEPLDFETAISTHTVTKPICEKGKKGEKKRKSITIMSQKASEDEEWYGNSDFETQSSFPRSGSPDQSAEMQIIKSRALTPESAEEHKETQKYTYTENGERVKIVHMKREEIINCHCGFREEDGLMVQCELCLCWQHALCHNIQSEAQVPEKYTCSICLNPRRGRRSQRFLHDQDRLYEGLLPGAKPCDLLRRSHELSGNLLRIQDALHALRVKCFVASKKDHPKLYLWAKDWEQAEISYTQEKLNSDYSDLNIMINTVGKENMPIKPEDMKDMQLGLSSDDADIDRFSQRDNQLSSNVLLNNLLSSPGGASLDLPISTSELETLAKSVQEQECGVAGVEVDVGVDVGVGAMMSVPSVCAPQPEAAIENGACRVRLLRHLQRCHALVDARLDSIEAQVAELESQDPSFEDDETPDFFPRTKQTVQMLLRDLDTMEELGSIT
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00341337;
- 90% Identity
- iTF_01010456;
- 80% Identity
- iTF_01010456;