Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_949126905.1
Location
OX421368.1:4430664-4453582[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 4.3 1.5e+04 -3.9 0.0 32 48 463 479 460 480 0.83
2 2 5.7e-16 2e-12 47.0 0.0 5 63 797 854 793 913 0.88

Sequence Information

Coding Sequence
ATGGCTGTAAAAAACTGTTGCATACGAACATGTAAATCCTGCTCGACAAGGAAGGAGGATAAAGGTGTCACATACCACAGATTTCCAAAAGACTTAATTTTACGTAACAAATGGATGTCTATAACTGTTTGCAATGATTTAGACTTGCCGAAGTATGTGTGCTCAAGACATTTCTGTAAAAATGACTTTCAAATGTATAAGGACTCTAAGTACATACTGAAGTCAGatgCAGTGCCTTCAATTTTTCCATGGACAATGTCTGACATAAATAATACCCAGAAGATGGAAACAGCAGACAATAAATTAGAAGATGATGCTTCAAACCTTCAGAACACAAAAGTAGACTTGAATACATCAGATAGTAGTAAGGAATCTGAAGAAAATCtggatgcaataaaaaaattcattGAAGATCAAGATAAAGAAATACAAGAGAGAGATGTTGCTGATAATGTTAGGGAGAATGTTGAAActgaaacaaacattaataaGGTTCCAAATAATGACCATGATGAAAGAGCCAGTAATGATAAAAGTAATGTCATTGATAAAAATACCACTAAAGATGTAAGTAATATTAAGGAAGACAATATCAATATGGATATAAATAATGACAATGAAAATGCCAGTAATGATGTAAATTGTTACAATGATGAAGATGCCAGTAATGTTTCTAATAATGACAATGAAGGGACAATGGTAGTTGGTACCAGTGTAATGGATATGATATTGAATGAATCTGGGGAAAAAATTGAGGACAAAAAAGATTTTACTGTGCCCAAATATAGTTTGAGTCCTGATAAAGttgctAGTGGCAGCATTTCTCTATCAGTTGGTTCAAGAATAGAAGCTAAAGATTTTGGTGATGAATGGCATCCGGCGCAGATTGTGGAGGTTGATTATGACGAGATGGAAGTCTTGGTCCGTTATGAACCACACAACAAGAGTATTTCGAGACATGACGAATGGATCAGCGTGAGTAGTCCACGGTTACGTCCAACAACCGACAAGTCTAAACATGAAACAAATGTATCAGACAAGATTCCCGAACAGGACGCACCAGTTAAGGAGGAAATCAAAGAAATAAAGGTAGAAGAGAAGCCGAAATTAACTTTCGCAGTGGGGGAGAGATGTTTGGCGCGTTGGAGAGATAATAGGAGGTTTATTGCAACCATACAAAATGATTTGGGGAATGGTGCGTATGAAATAATTTTCGATGATGGCTTCCACTGGAAATGTAACGTATCAAGGCTTTATAAGTGTAAACCGACCGGAAAGCAAGATGTTCTTACCGTAGATACATCGTTACATTCGCCAACTGGAGCCCCGTCTCCCATACAAGTTGGTGGTCCAAGCACTGCAGTCCCAACTAACACGACATTTTTTCACACGCATTTATTTGACCCCACACGAGATTACCTAAGTTCAAAAAGTGAACGACGTGAAATGAAAAGGAAATTGAATATAAAAGAGATATTTAATATAGGACAAAAGAGACAGAAAACTAAATCGGATAAAGTAGTGAGAAAGCCAAGAATCATACGACGTACTCCCAAAGTTAAAGCTGAACCTATTAAAAAGGAGCTGAAGGTTGAACTTAAAAGGGAGATACCTGATGCTGTCGCCTCTATCATTGGTACGGTTGATAAAAAACAGCCTGGGATAACAGAATTAACGAGTGAAGACATTATCGAAGTTAAATtagaagaaatagacaaggaTGATATTGAAATTACAGATGTTAAAGTACCTGAAATTGATAACACACAGGTAGcggataatttaaaaatggatccGTTTAAAGCAGAATTAGACCCTGTACACGAGGAAGATGTGAAACTTGAAAAATTTGATAAACAAGATGACGGTAAGCACGAAGAAGTAATCGATAGAATAAaagaagtaataaataaactggAGGGCGGTTTGAATGAGCAAATGGTGAATTCACCCAAAATAGAAACCAAGGAAGAAATCCCTGACAAAATTGAATCCGTAGATGCAAAACAAGAACCAGAAGGAAACGTCTCCATAGACGTCAACGAAGTCGTAACCACTAccccaaaaataaaatctaagaaACTATCAAAGATAAAGAAAGGTAAAAAACTGAGAATGTTGCAAGAGAAAAAGGTTAAGAAACAAGTACAGAAGGTTAAAAACGAACTTGAAGAGATGAAGCGGCAGGTGGAAGAGATGCGAAAGCAGATGTTGTTGAAAACGCAAGAGTTTGCGAGAGGACAAGCGGAGATGCCGGAGAGCTTTTTGTTGCCTGGCGAATGGTGTTGTCGGTGGTTAAACGGTCAACCTGTAGGAACGGTCAGTGAGATTGTGTGCGAGCCTAAGATCGATGGAGGGGGGAATCCAGGGTTGCCGCGGCGTAGCGTACAGGTGGAAGATAAGCGGTTACCTGCAGGCTGGACGAAACACATGGTACGCAGGAGTTTAGGACATTCAGCCGGAAAGTGGGATGTTGTGCTTGTGAGtcCAGAAAACCGTCGTTTCCACACAAAAACGGACATGCGTAATTACTTAGAAAACAATACCGATGAATCGCTAAAGCAGTACGAAGCGGCGTTAATGGATTTTGGGGTTCATTTAAAATTGGCCCGGCGTATGGGGTGGATCACGACGACTCCGGGTGGAGTGGCTGATGGGCCATCGTTACCATGTGGCACATTGCACAGTACCTCCCCATTAGTAAAGAGAAAGAAGCTATGTCTTAAGAAATCGGAGAAGAAATGTCGGGTGAAGAAAACCAGGGACAAGAAGAAGAAAATGTCTTTTAGGATAAAATTGGCTTTGTCTTCTCAGAACgcTGTTGACGAGACCTTAGATATTGATACTACTTGCAATTCCGTCGCGACCACAGAACCTGCTCTTGAAACTTTGACTTTAGAAGATGGATACGTTTACGTCGGATCCCTCAAAGTTCAAATAATAGAGAATCTTCTCCGATGTCCAGCTGACGGTTGCTTCAAGAATTTCCGAAACAACACGCTATTGCAAATGCATATTAAACATTACCATAGAGAATTGAGAGAAAAGTTAGGTGATACCCCTAAAGTTCTTGACTTGGCATATGCTAGAACTATGCCACTGGTGCCTGACCTGCCTCGACAAGCAGATTCTAAAGTTATTAAGGTTAAATTACCAAAACCGAAGCGCGATGAGCCTAAACTTGAACCTGTTGATGTCAAATCAGATTTACTAATTGATACTGGACCTAAAACACCACTTAGCCAAGAAGGTGATAGTATTCCAAAGACACAAGATTCGCCTAAATTGCGTGATGCGTTGATTACCAAGCCAGTGAAAAGACCAAAGGTTTTACTTCCTGTCAGGAGACCGGAGTTTGATCCAGAACTACAAAATGTGGACGATTATGAAGAATTACCAGAAATGCCAGTCGATGAAAGTTTGATGGAGCAGTTAGATTTTGAAACTGCAATTTCAACTCATACTGTGACTAAGCCAATTTGTGAAAAGAGTAAGAAAGGCGAGAAAAAACGAAAATCAATAACAATGATGTCGCAGAAGGCAAGTGAGGATGAAGAATGGTACGCGAACTCCGATTTGGAGACGAGATCTAGTTTCCCGCGGTCTGGCTCGCCGGACTCCAAGTCAGCGGAGATGCAATTATATAAGGCACGGACTTTAACGCCGGAGTCTGCTGAAGAGCACAAAGAGACGCAGAAGTACACGTTTACCGAGAATGGTGAACGTGTGAAAATAGTGCATATGAAGCGTGAGGAGATCATCAATTGCCACTGCGGGTTCCGTGAGGAGGACGGGCTCATGGTGCAGTGCGAGCTGTGTCTGTGTTGGCAGCATGCGCTCTGCCACAATATACAGAGCGAGGCGCAgGTGCCCGAGAAGTACACATGCAGTATATGCCTGAACCCACGTCGCGGTCGTAAATCCCAGCGGTTCCTGCACGATCAGGACCGTCTGTACGAAGGACTGCTGCCGGGAGCCAAGCCTTGCGACATGTTGCGACGCTCACACGAACTGTCCGGCAATCTGTTGCGGATACAGGACGCGTTGCACGCACTCAGGGTCAAATGCTTTGTGGCCTCTAAAAAAGACCATCCGAAATTGTACCTATGGGCCAAAGACTGGGAGCACGCCGAGATATCATACACTCAAGAGAAGCTTAACTCTGACTACTCAGACCTGAACATAATGATCAACACAGTGGGCAAGGAGAATATGCCGATGAAACCTGAGGACATGAAGGACATACAGCTCGGCCTGTCGTCTGATGACGCTGATCTTGACAGGTTCTCACAGAGAGATAATCAACTAAGCTCTAACGTGTTGTTGAACAACTTGCTGTCAAGTCCGGGCGGGACGTCACTCGACCTGCCCATAAGTACGTCCGAATTGGAGACGCTTGCCCAATCTGTTCAAGAGCAAGAGTGCAGTGTGTCGGAGCCCCCGCCGTGTGTAGTGTCGGAGCCCCCGCCGTGTGCGCCTGTGCCCGAGGCGGCGATCGAGAACGGCGCGTGCCGCGTGCGGCTGCTGCGCCACCTGCGGCGCTGCCACGCGCTCGTCGACGCCAGGCTCGACTCCATCGAGGCGCAGGTGGCAGAGTTGGAGTCACAAGACCCATCATTCGAAGACGACGAGACGCCCGACTTCTTCCCGCGAACAAAGCAGACAGTTCAAATGCTGTTACGAGATCTGGATACTATGGAGGAGTTGGGAaccattacataa
Protein Sequence
MAVKNCCIRTCKSCSTRKEDKGVTYHRFPKDLILRNKWMSITVCNDLDLPKYVCSRHFCKNDFQMYKDSKYILKSDAVPSIFPWTMSDINNTQKMETADNKLEDDASNLQNTKVDLNTSDSSKESEENLDAIKKFIEDQDKEIQERDVADNVRENVETETNINKVPNNDHDERASNDKSNVIDKNTTKDVSNIKEDNINMDINNDNENASNDVNCYNDEDASNVSNNDNEGTMVVGTSVMDMILNESGEKIEDKKDFTVPKYSLSPDKVASGSISLSVGSRIEAKDFGDEWHPAQIVEVDYDEMEVLVRYEPHNKSISRHDEWISVSSPRLRPTTDKSKHETNVSDKIPEQDAPVKEEIKEIKVEEKPKLTFAVGERCLARWRDNRRFIATIQNDLGNGAYEIIFDDGFHWKCNVSRLYKCKPTGKQDVLTVDTSLHSPTGAPSPIQVGGPSTAVPTNTTFFHTHLFDPTRDYLSSKSERREMKRKLNIKEIFNIGQKRQKTKSDKVVRKPRIIRRTPKVKAEPIKKELKVELKREIPDAVASIIGTVDKKQPGITELTSEDIIEVKLEEIDKDDIEITDVKVPEIDNTQVADNLKMDPFKAELDPVHEEDVKLEKFDKQDDGKHEEVIDRIKEVINKLEGGLNEQMVNSPKIETKEEIPDKIESVDAKQEPEGNVSIDVNEVVTTTPKIKSKKLSKIKKGKKLRMLQEKKVKKQVQKVKNELEEMKRQVEEMRKQMLLKTQEFARGQAEMPESFLLPGEWCCRWLNGQPVGTVSEIVCEPKIDGGGNPGLPRRSVQVEDKRLPAGWTKHMVRRSLGHSAGKWDVVLVSPENRRFHTKTDMRNYLENNTDESLKQYEAALMDFGVHLKLARRMGWITTTPGGVADGPSLPCGTLHSTSPLVKRKKLCLKKSEKKCRVKKTRDKKKKMSFRIKLALSSQNAVDETLDIDTTCNSVATTEPALETLTLEDGYVYVGSLKVQIIENLLRCPADGCFKNFRNNTLLQMHIKHYHRELREKLGDTPKVLDLAYARTMPLVPDLPRQADSKVIKVKLPKPKRDEPKLEPVDVKSDLLIDTGPKTPLSQEGDSIPKTQDSPKLRDALITKPVKRPKVLLPVRRPEFDPELQNVDDYEELPEMPVDESLMEQLDFETAISTHTVTKPICEKSKKGEKKRKSITMMSQKASEDEEWYANSDLETRSSFPRSGSPDSKSAEMQLYKARTLTPESAEEHKETQKYTFTENGERVKIVHMKREEIINCHCGFREEDGLMVQCELCLCWQHALCHNIQSEAQVPEKYTCSICLNPRRGRKSQRFLHDQDRLYEGLLPGAKPCDMLRRSHELSGNLLRIQDALHALRVKCFVASKKDHPKLYLWAKDWEHAEISYTQEKLNSDYSDLNIMINTVGKENMPMKPEDMKDIQLGLSSDDADLDRFSQRDNQLSSNVLLNNLLSSPGGTSLDLPISTSELETLAQSVQEQECSVSEPPPCVVSEPPPCAPVPEAAIENGACRVRLLRHLRRCHALVDARLDSIEAQVAELESQDPSFEDDETPDFFPRTKQTVQMLLRDLDTMEELGTIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00341337;
90% Identity
iTF_00063671;
80% Identity
iTF_00063671;