Basic Information

Gene Symbol
PEG3
Assembly
GCA_955612985.1
Location
OY015312.1:34554162-34557841[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 8.3e-05 0.0097 17.1 0.8 1 23 153 175 153 175 0.95
2 15 0.00088 0.1 13.8 2.0 1 23 181 203 181 203 0.96
3 15 0.00017 0.02 16.1 0.3 1 23 322 344 322 344 0.98
4 15 0.0038 0.45 11.8 0.2 1 23 350 372 350 372 0.98
5 15 0.00017 0.019 16.1 6.5 1 23 400 422 400 422 0.98
6 15 0.0073 0.86 10.9 0.3 1 23 433 455 433 455 0.94
7 15 0.005 0.59 11.5 0.6 1 23 461 484 461 484 0.95
8 15 0.23 27 6.2 0.4 5 19 495 509 492 510 0.91
9 15 3.6e-05 0.0042 18.2 5.6 1 23 519 541 519 541 0.97
10 15 0.017 2 9.8 0.5 2 23 547 568 546 568 0.96
11 15 8e-06 0.00094 20.3 1.0 1 23 577 599 577 599 0.98
12 15 0.00091 0.11 13.8 0.1 3 23 607 627 605 627 0.97
13 15 4.9e-05 0.0057 17.8 0.5 1 23 633 655 633 656 0.95
14 15 2.1 2.4e+02 3.2 0.5 1 23 666 688 666 688 0.93
15 15 0.014 1.6 10.1 0.0 1 20 1086 1105 1086 1108 0.93

Sequence Information

Coding Sequence
ATGGACACTCAAGCCTATGGAATCCCATCGTGGGTTCCGCAAATCGAGCGTAGTCATGCTGTCGATGACAATCCGGGAATGATAATCGGTGACTCGGAAGGTGATAGCGGCAATCACACAGACTACCTAGTTACCGAAGTGCCAACAAATCTCGACCAAATAGCTGCGGAAAATCTAATTTTCATGGCTCGAGATGGTCAGATGGAGATCATAGATGGCAACACTGATGTGGCCGACGGAAACGACGACAGTGGCATTGTCAACTTTCATGAGGATTATGCGGAAACCCAAATGGTTACAGAAGAGGTCATTACCGACGATTGGGTGCAGCATCAAGGCGAAGAAAGagttGAGATACCAGCAGATCAAATCTGTGGCTCCCTGTCACATATACCGGCTGAAGATATTGAAGTGCCTTTGCCAACAGTGCAGGATGAATACACCGCGTTGCGGCCGTATCCTTGTGACTTTTGCAGTCGGCGATTCCGCAAGAAGGGCAGTTTGATGAATCATATGGTGGCGCATCAAAACGATCGACCTCATGTGTGTAAGCTGTGTGGATCGCGTTTCTTTCGTAGAACAGACCTCATCAATCACCTTAAAGCCCACGCAGAAGCTTCAGAGTATGAGGACAACGATTACTTTGAGCCGCAGGGACATTCGCCACAGAACGACCACTACTATGATCAAGACTGGTCCACCACTGATGCGAGGCCGGCAAAGAAATCCCGCAGTAAGCGTGCACCAAAGGTACCTAAGGAGGACAATTACACAATTGATGAGACGCTAGGCAATCGAAACGAACATCCACAGCAAGAAGAAAAACACCACTATCACCAACAGCAGCTGCCACAGGAACACTATTACCAGCATCAGCAGCAAGAGCAATACGAAGAAGAGATCGTAACAGAGGTGGACACAAAGATTGTGCAGCGATTTCCCATCATCGATGATAACAAGCCGTTCGTCTGTCAACAGTGTGGCTTGTCATTTGCCCGAGAGAAGGCAATGCTGTCTCATGTCAAGACGCATCGCAATGACTCTGCATTTGAGTGTGGTACGTGCAACGAGATGTTTTGGGATGCCAACACACTGCAGGAGCATCAAAAATCGCATCAGTTCGAAGCGAGCAACTCGGAATACGAACCCGATGTGGACAATGAAAGTGATTCGGAATCAGAGTACAAATACGGTGAATTCTATTGCCACCAGTGTGGCATGTCCTTTCATCGCCAGGATCTGTTGCGTCGCCACAGCAAATCGCACATTAAGAAGGAGGTCATCGACAAGGATCAACATTGCTGTAATACTTGTGGAGAGACTTTTGCTGAGGCCTTAGATCTGCTGGCGCATGCGGAAATTCACGCGAGATATCCGCCTTTCAAATGTGTTCTATGTGGAGAGACCTTTTTTGAAGAATCTACCATTAAGCGCCATCTAACCAACCTCCACGAAGCCGAAATGACTTCTAATTCCTGTATCCTCTGCGGCAAGGAATGCCGCGATCGCAAGGCTCTTATGAAGCACGCCTGGGATCATTCTAGAGAGAAGTGTCATTCGTGTTCAAAGTGTGGAAAAAGCTTCCACAATAAAGCCCGCTTGAAGCGGCACATGGCTTCGCACCGGGACAAGTCGGTGGTTTGCAATGTTTGCAATGAAGAATTTCCCGATGGGAGGACTCTTTCAAACCACAGGCACTCGCATAGTGTCAACGCCTCGGGCAAACTCTTTCCTTGTCACGAGTGTGGAAAGACCTTCGGATCAAGGAGTTCGCAACAGATCCATGTGCGTATTCACACGGGAGAGCGGCCGTACGGCTGTCGTTACTGTTGGAAAGCATTCGCCGATGGTGGGACTCTTCGAAAACATGAACGCATTCACACAGGTGAGAAGCCTTATGCCTGTTCGGTGTGCCCACGTGCCTTTAATCAGAGAGTTGTCCTCAGGGAGCACATTCGGTCACACCACTCGGGGTTGGACACAAAACGTGGAACGTATTACTGTTCAGTCTGCTGTAGCGAGCTGCCCTCATCCTCGGAGTTAATTCAACATTTGATTCAGCACAGCGACATCAATACAGCCATGCAGCGGCAACCTGTGACTGGTCCACGAAAGTACAAACGTCGTCGAAAGCTGAAACCGCACGAGATCGATAGACTTCGCACGGATAACAAGACCAATAGCAGTGACATCGATATATCCGACTTTGATATGGACAATGTTGATGACCTCCTCGGCATTCCCACCTCAGCGaccagcaatacaaacaaacacaatcgAGATACATCTGCAGCGGCATCGCATCATTCACCAGCGGCGGCAGCCGTATCATTGGAATCACAAAGTGTCGGCTCGAAAAAACGCTACAACTCGACAGGCAGCTCAGAGAGACTCTCCAACAACTGGCACACCAAGTTGATCAACTCTACCAGCGATGACACCTACAAGTCGTTGCTGTCGAATCTCGAAAACACTTTGCAGAGTATCGACACTTTAGTTGTGAGTAATCCCTCGTCATACAACAACACCATCACGGAATCGCCAGCACCGGTTGCTGTCCCGAAAGTGCCAAAGACGCCACGACGAAAGAACGCAGCTGCGTCGAAAACATCCAATCGCCCGAAAATGATTCACACCGAAAAAGCGCGAGTTCCTATTGAAAACGGAAAACGGAAGTCGAAAACCTACGTAACCCGCACCGAACCAACTGAATTAGATATGTTTGCGCAGCGCTCTAAGCGCACAACACACGCGAATGACTACGAAATCATATCGCCGGATAAATACCCGCCAAAGCAGATCCAATCTAGTCCCGTTCATATAAAACAAGAAACAATCTGCACTCGCAGTGAGCTTTACGATGCCCAGCTGCTCCTGGAGGCAACATCCGCCCGCAGGGAGCTGGAAAACTATAACCCCGCTATAGTCAACGATTTGGAGGAGATCCTGCGATCCCCGGACAAATCAAAGTCACCCCGCCGACGCACGATCAGTGAGCGAACGGACGATGAGATCAAACCGGAGCCTTATTCACCTCATCAGCAGAATTTCGATTTTGTTCGAAGGTCAACGCGCCCCAGGCGGCCTGTAGTGAATAGGAAATACCTCGGCTATGAGACCGATCTGCCCGCACCAAAACCAAAGCCACGGTCAGATAAAAGAACAGTGGAGAGTAAACCTACAGCTGTTCGTAAGTCGCCTCCAATATCGTCACCTCCACCAGCACCAATTCCTCCGGTGCGCAAGCAACAATATTTCGAGTGTGAGATGTGTTCGGCTGTGTTCCCCGATCGCGCACAGCTTCTGGATCACGTACCTATCCACATATAG
Protein Sequence
MDTQAYGIPSWVPQIERSHAVDDNPGMIIGDSEGDSGNHTDYLVTEVPTNLDQIAAENLIFMARDGQMEIIDGNTDVADGNDDSGIVNFHEDYAETQMVTEEVITDDWVQHQGEERVEIPADQICGSLSHIPAEDIEVPLPTVQDEYTALRPYPCDFCSRRFRKKGSLMNHMVAHQNDRPHVCKLCGSRFFRRTDLINHLKAHAEASEYEDNDYFEPQGHSPQNDHYYDQDWSTTDARPAKKSRSKRAPKVPKEDNYTIDETLGNRNEHPQQEEKHHYHQQQLPQEHYYQHQQQEQYEEEIVTEVDTKIVQRFPIIDDNKPFVCQQCGLSFAREKAMLSHVKTHRNDSAFECGTCNEMFWDANTLQEHQKSHQFEASNSEYEPDVDNESDSESEYKYGEFYCHQCGMSFHRQDLLRRHSKSHIKKEVIDKDQHCCNTCGETFAEALDLLAHAEIHARYPPFKCVLCGETFFEESTIKRHLTNLHEAEMTSNSCILCGKECRDRKALMKHAWDHSREKCHSCSKCGKSFHNKARLKRHMASHRDKSVVCNVCNEEFPDGRTLSNHRHSHSVNASGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDTKRGTYYCSVCCSELPSSSELIQHLIQHSDINTAMQRQPVTGPRKYKRRRKLKPHEIDRLRTDNKTNSSDIDISDFDMDNVDDLLGIPTSATSNTNKHNRDTSAAASHHSPAAAAVSLESQSVGSKKRYNSTGSSERLSNNWHTKLINSTSDDTYKSLLSNLENTLQSIDTLVVSNPSSYNNTITESPAPVAVPKVPKTPRRKNAAASKTSNRPKMIHTEKARVPIENGKRKSKTYVTRTEPTELDMFAQRSKRTTHANDYEIISPDKYPPKQIQSSPVHIKQETICTRSELYDAQLLLEATSARRELENYNPAIVNDLEEILRSPDKSKSPRRRTISERTDDEIKPEPYSPHQQNFDFVRRSTRPRRPVVNRKYLGYETDLPAPKPKPRSDKRTVESKPTAVRKSPPISSPPPAPIPPVRKQQYFECEMCSAVFPDRAQLLDHVPIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00389816;
80% Identity
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