Basic Information

Transcription Factor Domain

TF Family: AF-4
Domain: AF-4 domain
PFAM: PF05110
TF Group: Unclassified Structure
Description: This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental disabilities [1]. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 2e-09 3.8e-05 23.2 0.4 25 130 34 139 27 177 0.61

2 3 1 1.9e+04 -17.3 31.2 462 484 186 207 161 216 0.54

3 3 5e-07 0.0096 15.3 0.1 341 381 256 296 231 304 0.81

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	2e-09	3.8e-05	23.2	0.4	25	130	34	139	27	177	0.61
2	3	1	1.9e+04	-17.3	31.2	462	484	186	207	161	216	0.54
3	3	5e-07	0.0096	15.3	0.1	341	381	256	296	231	304	0.81

Coding Sequence: ATGTCGGTCCAGGCGGAGCAAGCGGCTGCTGGAGGAGGTCCCGACAGCCGTCACGGTCACCGTCATCACGGGCATCATCACGGACACCATCATCATTCGAATCCTCTCGCAGCCACCGCTCCGCTCTTCCGTGCTCCCGTGAGGGTAAATCCCGACGCCCAGGATCGCGCCACTCAGCAAATCCAATCGAAGCTGGGCAACTACTCGCTGGTGAAGCACTTCGTACTCGACGACTCGAAGAGGCTCATCGGCATCGAGGGCGTCCCTGCGAGTCCGGCGCCGGCCGCAGCCTCCGGCCTCAGGACAAGTTCAAGTTCAGGGACGACCTCGAGGAGCTCACCGTCCGCCCAGGAATTCAAGAAACCTGGCGGTCCACGCACCAGCTCCAGCGGCTCGAGTAGTCACGCTTCCCAACGCGGTGGGTTCGTCAAACCGGCTGACGGGAAACCACCCTACAGTGGCAGGGGCAGCTACTCGGGACAACCCGTTAAACACGGCGGCAGCAGTAACGATCATCGCAGCCATGGGCTTCTTCCCGCCAAGGGTCCTCCTCCTAGTtcatcctcttcgtcctcctcctcctcctcctccacctcgaGTATCTCCTCTTCGTCCAGCTCAGCGAATCTCGGTGGGAACGCAAACTTCGACGGCGCCGCTGGAAACGTCAGCGCCGGAAGCACCGGAAGTACCGGAAGCAGGATACACTCGGTGGCTGGTCGACTGCCCAGGCTGCCTCTGGATAATGGAACGAATAGCCGGCACGGAGCTACCGAAAATTCTGCCGACCTTGAAAATATCCTGAAAGAGATGATGATGCCGCCGACTCCGCTGACGGCGATCGCACAGACCCCGAGGAAAGAACTGGAGTCAAAGTTCACTTTCAATCCTGTACTCGCCAAGcTGACCGAAGTCCCACCTGGCGAAGCCGCGAAGCCTCGTAAGTAA
Protein Sequence: MSVQAEQAAAGGGPDSRHGHRHHGHHHGHHHHSNPLAATAPLFRAPVRVNPDAQDRATQQIQSKLGNYSLVKHFVLDDSKRLIGIEGVPASPAPAAASGLRTSSSSGTTSRSSPSAQEFKKPGGPRTSSSGSSSHASQRGGFVKPADGKPPYSGRGSYSGQPVKHGGSSNDHRSHGLLPAKGPPPSSSSSSSSSSSSTSSISSSSSSANLGGNANFDGAAGNVSAGSTGSTGSRIHSVAGRLPRLPLDNGTNSRHGATENSADLENILKEMMMPPTPLTAIAQTPRKELESKFTFNPVLAKLTEVPPGEAAKPRK

Sequence clustering based on sequence similarity using MMseqs2