Basic Information

Insect: Cephus brachycercus
Gene Symbol: MBD-R2
Assembly: GCA_030142315.1
Location: JARQSX010000889.1:27479-35141[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 4.4e-17 1.7e-13 50.1 0.3 8 69 538 599 532 608 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	4.4e-17	1.7e-13	50.1	0.3	8	69	538	599	532	608	0.91

Sequence Information

Coding Sequence: ATGAAGCAACGATTCGCACGGTCGCGTGGGCCTTGCTACGAGATGCCGCCAACGGGCCCGAGAGGAATGGCGCGCAAATGTTGCGTGCCAAATTGCCAGATCGACGTCCGAGCTGTCCGCGGTAGGGGTATACCATTTCACAAGTTCCCGAAGGACACTATCCTTAGGAGCAAGTGGATTGCTTCTGGTGGTTTCGAACAAAACTTTAAACCCACGCCCGGACAATTTGTCTGCCATAGGCATTTCAAAAAGGCCGACTACGAGACCGCCAAAGGACAGAAGTTCGTATTGAGGAAAGGAGCGGTCCCGTCGGTTTTTCATGATTACGATAATCATCCAGATCCTATGACAATGCCTGTAAAGTCTTCTTCTTACGCTCAGGAAGATTTGGATCTTATTAATTCTGAGATATCTAATTTGGATCATATTGACTCTACAACTTTGACGGATGCACATACACCCAAGTCTGATAGCTGCAGTGAGGCTTACAATTCCAGACCAGCTTCTGCGGCTGATACATTTAATCCGTTTGAAACATCGGAGGTGAATGATGGTGAACAAAAAGTAGAGAAGGCAGAGCTTCCTCTTAAGGATATTAAGGACAATGTTGATGCAATCGAGAGTAAATTTAATCCTGCTACGAGGCAGCTGGGAGTTACTGAACTTGAAGATAAGGCAGAAAGTGCAGGGATCgatttgaaaatcatcaaaGAAGAGCCAGAGCAGGTTGCTACAactgaagataaaaaaagtgttgAGAATGGAGATTCTAAAGTGAAAGTGATGAGTCGTGGTggcttgaaattttttcctgGTGCTAAGTTAGAGGCTAAAGACTTCAATGAGAAATGGTATTCTGCAAGAGTAGTGGAAACAGACTGGGTTGAGAGAGAAGTGTTGATACATTTCGACAAGTGGAGTTCTAGATTTGATGAGTGGATACCTATGGACAGTTCCAGATTACGAGTACTTCAAATACAGCCAAGcGAGCCTACTTGGACGCTGCCATCTCCGGAAACGAAGATGCGTGAATTTGTCGTCGGTGAGAAGATCCTGGCTACGTGGGCGGATGGCAGAAAGTATCCGGCCAGAGTGAACGCTGTGTTGGGGAACGATAGATACGACGTTCTGTTCGACGATGGATACACGAAGATCGTCAGGTCCTCGAAGATGACTAAAATCGCTACCACGTCCGAGAAGAAGTCGGTTGAGGGGGATTATATAGGGAGTAAGCAAGAGAGAAGAGACAAGAAGCGGAAGCATACTGTGATGGAGCTGTTTCATACGCATAGCAAGAAACGTCAGAAAGTTGAGGTAGAGCGTCCgataaagaaggaagagagtgTGCTCAGTGAGGACGATGGAAAGCTTGATCTGGGCGATTCGGTTCTTGGTACTTCTTATGACTCGGGATCAGAGGTTTTGCGTGGCTTTGAGAATACCAAACCTAAGATGAAGACGTTCActaagaagaagaggaaggaatTCATGAGGAATGAAACTGACAATGAAGAAGATATTGGTCCTGAATGGATCGATGGTGAACCACAAGGCCTTGAGTCTTACATCGTAGATGGCAATGATGGTCCTCGTCGTTCCATCATCGTTCCCGATAAGAGGTTACCACCAGGATGGCAGAAGCATTTTACACAAAGGCGTACAGGCTCCTCAGCTGGCAAATGGGATGTTCTCTTCATACATAAAACAAGTGGCAAGAAGTTCCGATCCCGAAACGATATCAGAGCCTTCATGGAGCAGCAAGGTCAATTCGACTTTGACCCAGAGAAATTTGACTTTTGCATTCACCGTAAGAAAACCAGCAAGTTTAATGTGATGAGACTCAAGCAAGAGACACCTCCGGACGTTcctaggaaaataaaaactcttCTGCCTAAAGCAAAGACATCTACGCCAGAAAATACATCTTTTCTGTCATTGACTCCAGTGACCCTTCCGTCAGCTACACCATTGACCCCGGTCGACAGCGGCGCCGTCTTCATAGGTGGCCTTCGCGTCGAAATGGAAGATAGCGCATACAAGTGTCCTAAGGAAGGATGCAACAAGAACTTTCGCAAAGAGAATCTCCTGCAGATGCACATAAAGCATTATCACCCAGAGTATTCCAAGTTCCTGGGCTCAACGCCAAATGTCGCTGACCTGGCCTACGCCAGGACTATAGGAGAGTCCATCGAGGACATCATACCCAAGAAACCAAACAATTTCCTGGAGAAGATCAACAAAttcgagaagaagaaggcagGCCATGAAAAACCTTTGACTCCGGTAGTAGAGTGTGAAACTCCTCGACCAGACAAACCTACCACCATTGTCAAGGAAGAGACCAAATTAGAAATCTTGTCGCCTACCTCCACCCAGAGTATCGATATGGATGAAGACAGTAAGAAACGTGAAAGTAATTGCGCCATGTCGCCAGGTACTCTCTTCGACATGAAAGTCAGGGAAGAGAAGACTCAAGTGGGAATTAAAACTCTACTTCCTGTGAGGCCAGCATCCACTGCGGAGCCTTTGAAACTTGACAGATCCAAATCTTTGGACGAGTCGACTCATCCTGACAAAGGAAAGGTACAAAAGAAGCGACAGCTGTCCGAGTACAGTACGGACTTTCCTGGGAAATCTAAGAAGAAGCAAGGCATGCAGGAGCTTATGGATGATTATGGGGATTTAGATGACAGTGCTTTGGATGTTGAAGAACCTGCTACTCCAATGTACAGATTCAGTCGCAGAAAATCAGATCCAAAAAGCGACGAGAACAGCCAGAGCAGTCAGCTAAACGATACTCGCCATGAGAAAGGCGATACCCCTAAGGGGGACGCTGCCAAAAGAGATAATATTANNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTTTAGGTCAGCTAAACGATACTCGCCATGAGAAAGGCGATACCCCTAAGGGGGACGCTGCCAAAAgagataatattaatgatgtCGAAgAAGGCGAGGGTGTCATGATGCTGATCAACGGGGAGATGGTGAAAGTTGAACAGCTACGTCGGGAGGAGATAATCAATTGCACCTGTGGATACATGGAGGAGGACGGTCTTATGATACAGTGCGACCTTTGTCTATGCTGGCAACACGGGCACTGCAACGGCATCGAGAGGGAAAAGGACGTGCCTGAGAAATACGTCTGTTACATATGCAGGCATCCTTACAGACAGCGGccatctttaaaatattttcatgaccAGGATTGGATCAAGGAAGGAATACTACCAAGTTTACCGAATCGTTCGAAAAATCAAGCCGCCATTAACCAGAGGACCGCTATGTTGAAACGCTCGTACGATTTGGTAGGAGCTCTTTTGCAGATACAGCAAGTTCTCCACAGTCTGCGTGTCAAGATCAACGTGGCACAGAAAAAGGATCATCCAAAATTGTATCTGTGGGCTAAGAACTGGGAGAAGAGCGAGATACCAAAACCGGATACGGATCCGGTGCCTGTAATGGAGATCATAAAGACACCGTTGGATTCAATGGACACAGCTTCGGAAACTTCACACTCTCTGGACCCCAAGGTAGAGTTTAAGGAGGCCGTCAAGGAGGATCCGGATAAGAAGTCCATTGCTTCGGATACGGAGCTCATGAAGATCCTTGAAGAAGACAGTACACACTCGGACGAGTCTAAGGTCATCAAGAAGGAAGATACTCAGACGGATGGACATATTCTATTGGATGCACTCACCAGGACAAGCAGTCCCGAGAAGAAGACGTCCGAGAATCTCAGTGAAAATCCGGATACTCCAAGCGTGGATCTCCCGTCGACGTCTCAGAGTCCACTGGCAGTTTCCACACCGGgaactgaaaatattacacaGGAAACCAGTCCTCTCGCTCAACCTGAGACTGTTCCGCCTATGCAACCTTTTATTCCTGAACCGGAAGCTCCCATTGATCCAGCGGAATGTCGATTAAGATTATTGGAGCACATCGAACACTTTCAGAATCATATCGACTCCAGATTAACCACCATCGAGGCTCAAGTGTGCGCACTGGAAGCCATGGATCCGGATGACCCGACATCCAGTGTGGATGTTCTACCCAGGACCAAGCAAACTGTACAAATGTTACTCAGGGACTTGAATACTGTACGAAAATTAGCTGCACTCTGCTGA
Protein Sequence: MKQRFARSRGPCYEMPPTGPRGMARKCCVPNCQIDVRAVRGRGIPFHKFPKDTILRSKWIASGGFEQNFKPTPGQFVCHRHFKKADYETAKGQKFVLRKGAVPSVFHDYDNHPDPMTMPVKSSSYAQEDLDLINSEISNLDHIDSTTLTDAHTPKSDSCSEAYNSRPASAADTFNPFETSEVNDGEQKVEKAELPLKDIKDNVDAIESKFNPATRQLGVTELEDKAESAGIDLKIIKEEPEQVATTEDKKSVENGDSKVKVMSRGGLKFFPGAKLEAKDFNEKWYSARVVETDWVEREVLIHFDKWSSRFDEWIPMDSSRLRVLQIQPSEPTWTLPSPETKMREFVVGEKILATWADGRKYPARVNAVLGNDRYDVLFDDGYTKIVRSSKMTKIATTSEKKSVEGDYIGSKQERRDKKRKHTVMELFHTHSKKRQKVEVERPIKKEESVLSEDDGKLDLGDSVLGTSYDSGSEVLRGFENTKPKMKTFTKKKRKEFMRNETDNEEDIGPEWIDGEPQGLESYIVDGNDGPRRSIIVPDKRLPPGWQKHFTQRRTGSSAGKWDVLFIHKTSGKKFRSRNDIRAFMEQQGQFDFDPEKFDFCIHRKKTSKFNVMRLKQETPPDVPRKIKTLLPKAKTSTPENTSFLSLTPVTLPSATPLTPVDSGAVFIGGLRVEMEDSAYKCPKEGCNKNFRKENLLQMHIKHYHPEYSKFLGSTPNVADLAYARTIGESIEDIIPKKPNNFLEKINKFEKKKAGHEKPLTPVVECETPRPDKPTTIVKEETKLEILSPTSTQSIDMDEDSKKRESNCAMSPGTLFDMKVREEKTQVGIKTLLPVRPASTAEPLKLDRSKSLDESTHPDKGKVQKKRQLSEYSTDFPGKSKKKQGMQELMDDYGDLDDSALDVEEPATPMYRFSRRKSDPKSDENSQSSQLNDTRHEKGDTPKGDAAKRDNIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLGQLNDTRHEKGDTPKGDAAKRDNINDVEEGEGVMMLINGEMVKVEQLRREEIINCTCGYMEEDGLMIQCDLCLCWQHGHCNGIEREKDVPEKYVCYICRHPYRQRPSLKYFHDQDWIKEGILPSLPNRSKNQAAINQRTAMLKRSYDLVGALLQIQQVLHSLRVKINVAQKKDHPKLYLWAKNWEKSEIPKPDTDPVPVMEIIKTPLDSMDTASETSHSLDPKVEFKEAVKEDPDKKSIASDTELMKILEEDSTHSDESKVIKKEDTQTDGHILLDALTRTSSPEKKTSENLSENPDTPSVDLPSTSQSPLAVSTPGTENITQETSPLAQPETVPPMQPFIPEPEAPIDPAECRLRLLEHIEHFQNHIDSRLTTIEAQVCALEAMDPDDPTSSVDVLPRTKQTVQMLLRDLNTVRKLAALC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00291584; iTF_00252866; iTF_01395171; iTF_00255081; iTF_00252817; iTF_01395124; iTF_00255130; iTF_00292995; iTF_00292948; iTF_00295300; iTF_00296837; iTF_00296780; iTF_00295248; iTF_00770372; iTF_01198665; iTF_01199405; iTF_01130864; iTF_00770421; iTF_01198714; iTF_01130814; iTF_01199456; iTF_00252070; iTF_00254376; iTF_00254325; iTF_00252123; iTF_00298311; iTF_00298363; iTF_01473226; iTF_01475503; iTF_01474742; iTF_01473179; iTF_01475451; iTF_01474688; iTF_00292270; iTF_00292311; iTF_00297551; iTF_00297599; iTF_00296016; iTF_00296064; iTF_00253617; iTF_00253567; iTF_01473972; iTF_01473926; iTF_00293721; iTF_00293767; iTF_00294526; iTF_00294478;
90% Identity: iTF_00294526;
80% Identity: iTF_00291584;