Basic Information

Gene Symbol
-
Assembly
GCA_905231865.2
Location
HG993135.1:14535238-14538098[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 2.4 2.2e+02 3.2 1.9 3 22 446 465 444 468 0.90
2 9 0.25 23 6.3 2.3 2 19 490 507 489 521 0.93
3 9 0.001 0.094 13.8 5.0 1 23 527 550 527 550 0.97
4 9 0.00099 0.092 13.9 0.8 1 23 555 579 555 579 0.92
5 9 4 3.7e+02 2.5 0.8 2 23 600 624 599 624 0.86
6 9 0.00024 0.022 15.8 0.2 2 21 630 649 629 650 0.96
7 9 0.00012 0.011 16.8 0.7 1 23 707 728 707 728 0.98
8 9 0.00038 0.036 15.2 1.4 1 23 734 757 734 757 0.89
9 9 0.11 11 7.4 0.4 2 13 781 792 780 792 0.91

Sequence Information

Coding Sequence
ATGCTGTCACCTCACGACGACGACGATGACAGCCACCTGTGCATCAAATGTAATGCGACTATTATCGGCCTCGATAATTATGTCAAGCATAGAAAACAAGCCTGCGGCAAAAGAAAAAATGAAACAAAATCAGAACTCCCATCCATTGACCCGTTAGAACCAACTTACAGTCTTGGTGCAGATGTATTTTTTCAGTCATTAGAATTGCAAAGTAGCGTTAAAAAGTCATCACTGTCACGATTAACACCACCTACAACAATATCTAAGGCAAGTTCAGCAAATATTGATAAGAAAGTTGCTTTGACTGTTTCTTCGACTTCTAACCATCCTCGTATGAGTCCTATAGAAACTAATTTAAGAGGAGAAGATTGGATCGGTGGGCACAGCCTTAGGATAGGTAGTAATGAAGATAATCAGACAAAACTAATTAACGCTGTCGCTAGTATCAGTGGTTCAGTAAAAAAGGATCTTCCGAGTACATCATATAATATAGAACCTTTTAATGACTTTAAGGGTGACGATGAGTCAGAGGAATCTGACGATTCAGATGAAGATGAGGATGAAGATGAATTACCTCTTGGCGGTAAATGGAAACCACCACCAAATTACACCGGGGGTAAGTGGCGACCTGCGTCTCCAGAACGGGAAGAGTGGGAAGAGCAGGAACAACTCGACCGTGACTATGATTATGACGCACCACCTCCAGGCCATACAAAAGGAAAATGGGTACCCGGAGCCAATGAAAAGACACAAATAATGCAAACTACAATTCAAGCAAAGGGTTCCGTACAATATTGGTGTGGACCATGTAACCGTCGCTTAGGGTCGAGAGCTATTTATGACAAACATCTTATGTCGAACTTACATATGCGGAAGGTGCTTCCAGAACATGAACTAGAATTTTCAGGACATTTGGAGCCTATAAGAAATGTACCCGATAAGAGAACATCTCGTCCCACATTATTTGCAAGTGAGTCCATTTCACAAGCTCATCGAAAAAGACAAAAATTAGAACCTAAACTAAACATTAAGATTAAGAAAAAGAAACGAAAAAGGAAGAGTTATTTTATTCAATGCTCTGGTTGCAAATCAAGAGTCCGCACACATTTAATGGGAAAGCATTTAATATCACACTACCACTTTAGAAAAGCTGCTGATATAAAAAGTGATACTTACCAACAATTTATTGTTGACAACATGGATGCGATAGTACACCAAGCACCTTTCCAATGTAGTCCATGTAAGTTTTACACAAACTGGCTTTCTAATTTTATGCAACATTGGTTTTCTGAAGAACATGAAAGTAAGGTCACTTCAATGGATGGTAGGTATTGGTGCTCTTTTTGCAAATTTGAATGTGAGACCTCTCAAGACATGTTGAATCACATGTCTAGTTCAGAACATAGTGAGGTCATAGCTGTAATAAATAGATCCATGCCAATAATAATAAGGAAGAAAACAGTACTACGCTGTGAAACATGTAAAAAAGAATTTCGTTATAACATGGAAATCAAACAACATTGCTTAAAAACGGGTCACGAATGTCCTTATAGTGCAACTGATAATTATCAAGAGCTACACAAATGCCAGCACTGCAAAGTAAAATTCAAGTCTTCAGTAACTTTGGCGGCGCATTTGAAATCCAAGCACAAACAAAAAGCATACTTCTGTCTCGTTTGTTCGAAAACTTTTGCGTCTTCAGAAGAAGCTAAGCGACATCGGCAAACGTCAGAACATAGAGTTAGAAGGAAAGAGATTCTACGTGAACGAGGAGAAACTACTAAAGACCTCAGTAAGAAATGCCCTTATTGTACAGATAAGGTCGTGTTAAAGAATATTCTTGAACTCAAAAACCATATACAACGAGTACACCCAGATATAAGAAAGAAGTGCCCAAAATGCGGAAAAGCTTTCATTTTTTCACAAGAAGTTTCTAGACATATTCGAGACAACGCCTGCCAGTTCCAAAAGGACGAAACGATTAACTCATCGATTCTTTGGAACTGCAGCCAATGTCTATTCACCACCGACTCACAGGCAGAGTGTTTCTTCCACGAGGTTCTTCACACAAAACCAATTATAGAAGCAAAAGATGGAAAGAATAAATCTATAGAAAAATATTCATGTCCTATTTGCTCGAAGATCTTCAAAAAAGCCTCCTTACGCCTACATTTAAGGCAGCACACATTTGAACGGCCTTTCATTTGTTCTACGTGTGGTGCCAATTTCACTCGACAGTCAAGTTTAGCGAACCATTGTAAGATCGAGCATGGGAGCATGGATCGACCGAAGCTGACCTCAATTAATGCTACTCTAATGAAAATAGCAGAGGAGACGCTAAGGTGTACCAAATGTAAAAAGATGTTTAGTGATTGGTAA
Protein Sequence
MLSPHDDDDDSHLCIKCNATIIGLDNYVKHRKQACGKRKNETKSELPSIDPLEPTYSLGADVFFQSLELQSSVKKSSLSRLTPPTTISKASSANIDKKVALTVSSTSNHPRMSPIETNLRGEDWIGGHSLRIGSNEDNQTKLINAVASISGSVKKDLPSTSYNIEPFNDFKGDDESEESDDSDEDEDEDELPLGGKWKPPPNYTGGKWRPASPEREEWEEQEQLDRDYDYDAPPPGHTKGKWVPGANEKTQIMQTTIQAKGSVQYWCGPCNRRLGSRAIYDKHLMSNLHMRKVLPEHELEFSGHLEPIRNVPDKRTSRPTLFASESISQAHRKRQKLEPKLNIKIKKKKRKRKSYFIQCSGCKSRVRTHLMGKHLISHYHFRKAADIKSDTYQQFIVDNMDAIVHQAPFQCSPCKFYTNWLSNFMQHWFSEEHESKVTSMDGRYWCSFCKFECETSQDMLNHMSSSEHSEVIAVINRSMPIIIRKKTVLRCETCKKEFRYNMEIKQHCLKTGHECPYSATDNYQELHKCQHCKVKFKSSVTLAAHLKSKHKQKAYFCLVCSKTFASSEEAKRHRQTSEHRVRRKEILRERGETTKDLSKKCPYCTDKVVLKNILELKNHIQRVHPDIRKKCPKCGKAFIFSQEVSRHIRDNACQFQKDETINSSILWNCSQCLFTTDSQAECFFHEVLHTKPIIEAKDGKNKSIEKYSCPICSKIFKKASLRLHLRQHTFERPFICSTCGANFTRQSSLANHCKIEHGSMDRPKLTSINATLMKIAEETLRCTKCKKMFSDW