Acen011773.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Atethmia centrago
Gene Symbol
foxc1a
Assembly
GCA_905333075.2
Location
HG995370.1:8387723-8388685[+]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 3e-36 8.1e-33 114.2 0.0 2 87 76 158 75 159 0.96

Sequence Information

Coding Sequence
ATGTGTAGCGGCGCCGAAGGAGGCCCCTGGCCGCTCGGGAAGGACGCGCCAACAGTGACCGCCGCGGCTCTCGACCACTATCGCTTGCAATTGTACAACTATGCAGTCGCTGAGCGACTCCGCCTGTACCCACCGTCCGTGGCGCCGTGCTACGCGCCCTACGGGCCCCGGCTGGCGCTCTCCATGTCGCTGCTGCAGCAACGAGTCCTGCAGCCCGAGGAACCGAAGCCGCAGCACAGCTACATTGGCCTCATCGCCATGGCGATCCTCAGCTCGCCAGATCGGAAACTAGTCCTCTCAGATATCTACCAGCACATCCTGGATAATTATCCGTACTTCCGCTCCCGTGGACCTGGTTGGCGCAACTCAATACGACACAATTTGTCCCTTAACGACTGTTTCGTTAAAGCTGGAAGGTCGGCCAATGGGAAAGGCCACTATTGGGCTATTCATCCAGCCAACATTGAAGACTTTCGCAAAGGAGACTTTAGAAGACGCAAAGCACAAAGGAAAGTGAGAAAACACATGGGATTAGCTGTTGACGATGATGGTGAGGACTCACCGTCTCCGCCGCCACAGTCGCCGCCGCCGACGGCGCTGCCGCTGCCATTCTGGGGAGCGGGCCGGCTGCCCGGCGGAGCACAGGCGCGTAAGAGACAGTTCGATGTGGCGTCACTGCTGGCGCCGGACGACGCGCCCGAGAAACGTCAGCGGCGTGACAGCAGTTGTGAGGAGGAGCCAGAAGAAGACATCGACGTGGTGGCGAGCGACCAGGAGGAGCGCGGAGAGGAGGAGGTGCGCGAGGGGGGGCGCGCGCTGCCGGCGCCGGCCGCGCAGTACCCGCTGCTGGGCGGCTGGTGGCCGGCGCTGGACCCCGCGCTGCTGCAGCAGCTGCGCCGCTCCGCGCTGGCGCCGGCGCCGGCGCCCCCCAGCCCTGACCAGCAGCGCCCGCCCGACACCTAA
Protein Sequence
MCSGAEGGPWPLGKDAPTVTAAALDHYRLQLYNYAVAERLRLYPPSVAPCYAPYGPRLALSMSLLQQRVLQPEEPKPQHSYIGLIAMAILSSPDRKLVLSDIYQHILDNYPYFRSRGPGWRNSIRHNLSLNDCFVKAGRSANGKGHYWAIHPANIEDFRKGDFRRRKAQRKVRKHMGLAVDDDGEDSPSPPPQSPPPTALPLPFWGAGRLPGGAQARKRQFDVASLLAPDDAPEKRQRRDSSCEEEPEEDIDVVASDQEERGEEEVREGGRALPAPAAQYPLLGGWWPALDPALLQQLRRSALAPAPAPPSPDQQRPPDT*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00072065; iTF_00345633; iTF_00973537; iTF_01061697; iTF_01280001; iTF_00040610; iTF_00237282; iTF_01064450; iTF_01084066; iTF_00745443; iTF_00751843; iTF_00043300; iTF_00185956; iTF_00282084; iTF_00363844; iTF_00622628; iTF_00757956; iTF_01025796; iTF_01531780; iTF_00000133; iTF_00445925; iTF_00448837; iTF_00683141; iTF_01030949; iTF_01440805; iTF_00425190; iTF_01377286; iTF_00017159; iTF_00185127; iTF_00830983; iTF_00318696; iTF_00706760; iTF_01029033; iTF_00017994; iTF_00850410; iTF_00905930; iTF_01062570; iTF_01332362; iTF_01027116; iTF_01063564; iTF_01166412; iTF_01180140; iTF_01334572; iTF_01532844; iTF_00147117; iTF_00447981; iTF_00637293; iTF_01028077; iTF_00621838; iTF_00711630; iTF_00787438; iTF_00851534; iTF_00042447; iTF_00960751; iTF_01073423; iTF_01501903; iTF_00382384; iTF_00907696; iTF_00038513; iTF_00236465; iTF_00374993; iTF_00120306; iTF_00408210; iTF_01246642; iTF_01285362; iTF_01526834; iTF_00290483; iTF_01092883; iTF_00049716; iTF_00071220; iTF_00280948; iTF_00446932; iTF_00809876; iTF_01342036; iTF_01534612; iTF_01361397; iTF_01525749; iTF_00124054; iTF_00726102; iTF_00908630; iTF_00924406; iTF_01029974; iTF_01533750; iTF_00274263; iTF_01119095; iTF_01230327; iTF_01259895; iTF_00036440; iTF_01192440; iTF_00037593; iTF_00157017; iTF_00300985; iTF_00808921; iTF_01118073; iTF_00111418; iTF_00951610; iTF_01084954; iTF_00039611; iTF_00041595; iTF_00928475; iTF_01094715; iTF_01116987; iTF_00176924; iTF_00301916; iTF_00858364; iTF_00122173; iTF_00906877; iTF_01362909; iTF_00121214; iTF_00123166; iTF_00299966; iTF_00444926; iTF_01221310; iTF_00373727; iTF_00685247; iTF_01071455; iTF_01093855; iTF_01339775; iTF_01362303; iTF_01424863; iTF_01338304; iTF_01439712; iTF_01502787; iTF_00026663; iTF_00467272; iTF_00468011; iTF_00027578; iTF_00681479; iTF_00932234; iTF_00889007; iTF_00931039; iTF_00076269; iTF_00819873; iTF_01281121; iTF_00000999; iTF_00427911; iTF_01125260; iTF_00428817; iTF_00827796; iTF_00074294; iTF_01282038; iTF_00818967; iTF_01429751; iTF_01220472; iTF_01124416; iTF_01491695; iTF_01503664; iTF_00832721; iTF_00985812; iTF_00284342; iTF_00794137; iTF_01569081; iTF_00869439; iTF_00035456; iTF_00034520; iTF_00146209; iTF_00162323; iTF_00888033; iTF_00942627; iTF_00771691; iTF_00326902; iTF_00651549; iTF_01435876; iTF_00355942; iTF_00354905; iTF_00177895; iTF_01336642; iTF_00844133; iTF_01500920; iTF_00806510; iTF_01401100; iTF_00935496; iTF_01020041; iTF_01090506; iTF_00834445; iTF_00984845; iTF_00776593; iTF_00457830; iTF_00777254; iTF_00779334; iTF_00722855; iTF_00775080; iTF_00781640; iTF_00896588; iTF_00778607; iTF_00925551; iTF_00247856; iTF_00621040; iTF_00780081; iTF_00212242; iTF_00213234; iTF_00780854; iTF_00246999; iTF_00774327; iTF_01181719; iTF_00159644; iTF_00777821; iTF_00008718; iTF_01463979; iTF_01140046; iTF_01141473; iTF_01158529; iTF_01496387; iTF_01153669; iTF_01156101; iTF_00197192; iTF_00840137; iTF_00180268; iTF_01115533; iTF_01148654; iTF_00421167; iTF_01129872; iTF_01495600; iTF_00419601; iTF_01154833; iTF_01142227; iTF_00957781; iTF_01144373; iTF_01140758; iTF_01149398; iTF_01147927; iTF_01337591; iTF_01494137; iTF_01145882; iTF_01176027; iTF_00855708; iTF_00922716; iTF_01138780; iTF_00249533; iTF_00204190; iTF_01145118; iTF_01402559; iTF_01494879; iTF_00656961; iTF_00640098; iTF_00011759; iTF_00012752; iTF_00171575; iTF_01302107; iTF_01538555; iTF_01033538; iTF_00842468; iTF_01034350; iTF_00959987; iTF_00958524; iTF_00461373; iTF_00959231; iTF_00325187; iTF_00021155; iTF_00156071; iTF_01134603; iTF_00462189; iTF_00342031; iTF_01135571; iTF_00155130; iTF_00341155; iTF_01179319; iTF_00418787; iTF_00420363; iTF_01133539; iTF_01436835; iTF_00288676; iTF_01463076; iTF_00411237; iTF_01543717; iTF_01545577; iTF_01542773; iTF_01544696; iTF_01546459; iTF_00353894; iTF_00457062; iTF_01489958; iTF_00647815; iTF_00682183; iTF_00744423; iTF_01010183; iTF_00063393; iTF_01151879; iTF_00736438; iTF_01387431; iTF_01340967; iTF_01386538; iTF_01385520; iTF_01388284; iTF_01453095; iTF_01016385; iTF_01451288; iTF_01452154; iTF_00277192; iTF_01317096; iTF_00112329; iTF_00113154; iTF_01316137; iTF_00715626; iTF_01331242; iTF_01333545; iTF_00278929; iTF_00075275; iTF_00149195; iTF_00148303; iTF_00772693; iTF_00166763; iTF_00287878; iTF_01082253; iTF_01359535; iTF_01437784; iTF_01152859; iTF_01438715; iTF_00673310; iTF_00795520; iTF_00323307; iTF_00723787; iTF_00783243; iTF_00994187; iTF_01072267; iTF_00289444; iTF_00654053; iTF_01078891; iTF_00871116; iTF_00383437; iTF_00859277; iTF_01416589; iTF_00761443; iTF_00186958; iTF_01178222; iTF_00822703; iTF_00674128; iTF_00801616; iTF_01091513; iTF_00970224; iTF_00971051; iTF_00659281; iTF_01358705; iTF_00025093; iTF_01547345; iTF_00007826; iTF_00410098; iTF_00784210; iTF_00412339; iTF_00409104; iTF_00449939; iTF_00235687; iTF_00273428; iTF_00680340; iTF_00006901; iTF_01083116; iTF_01173088; iTF_00432950; iTF_00947716; iTF_00431948; iTF_00636087; iTF_01564374; iTF_00352855; iTF_00953335; iTF_00954227; iTF_01415639; iTF_01312056; iTF_00364729; iTF_00364728; iTF_00782457; iTF_01245753; iTF_00785018; iTF_00786586; iTF_01222299; iTF_00006108; iTF_01081400; iTF_00256668; iTF_00255633; iTF_00072542; iTF_00261662; iTF_00404510; iTF_01173089; iTF_00660126; iTF_00775870; iTF_01079711; iTF_01078007; iTF_00207680; iTF_00208650; iTF_00658176; iTF_00655911; iTF_00708992; iTF_00124978; iTF_01207927; iTF_01209020; iTF_00197942; iTF_00204947; iTF_01021006; iTF_00275064; iTF_00720024; iTF_00358337; iTF_01151041; iTF_00710850; iTF_00347331; iTF_01206371; iTF_00114756; iTF_00430438; iTF_01506983; iTF_00770921; iTF_00824523; iTF_01507883; iTF_01561835; iTF_01506156; iTF_00875117; iTF_00642160; iTF_01202288; iTF_01205520; iTF_00843316; iTF_01203860; iTF_01204692; iTF_00710005; iTF_01017557; iTF_00796342; iTF_01193430; iTF_01203062; iTF_00357239; iTF_01018395; iTF_00874268; iTF_00878684; iTF_00875968; iTF_00825400; iTF_00826640; iTF_00077306; iTF_00821594; iTF_00150299; iTF_00194997; iTF_00695293; iTF_00823741; iTF_01360426; iTF_00441301;
90% Identity
iTF_00942627;
80% Identity
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