Mleu017945.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Macrosoma leucophasiata
Gene Symbol
foxc1b
Assembly
GCA_036365455.1
Location
JAWQUS010000021.1:6352432-6353379[+]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 2.2e-36 3.1e-33 114.5 0.0 2 87 76 158 75 159 0.96

Sequence Information

Coding Sequence
ATGTGCAGCGGAGCCGAAGGAGGCTCCTGGCCGCTGGGCAAGGACGCGCCCGCCGTCACCGCCGCCGCTATTGATCACTACAGACTCCAACTCTATAACTATGCCGTCGCCGAACGCCTCCGCCTCTACCCGCCGGCCGTCGCTCCCTGCTATGGCCCGTACGCGCCGCGCCTGGCCCTCTCCATGTCGTTGCTGCAGCAGCGCGCCTTGCAACCGGAAGAACCCAAGCCGCAACACAGCTACATCGGTCTAATCGCCATGGCCATCTTGAGTTCACCGGAGCGCAAACTAGTGCTCTCCGACATCTACCAGCACATCTTGGACAATTATCCGTATTTCCGCTCCCGCGGCCCCGGCTGGAGGAATTCCATCCGGCATAACTTGTCGCTGAACGACTGCTTCGTGAAGGCGGGCCGCTCCGCCAACGGAAAGGGCCACTACTGGGCGATCCATCCTGCGAATATCGAAGACTTCCGAAAAGGGGATTTCAGGCGACGCAAAGCGCAGAGGAAAGTGCGGAAGCATATGGGCCTCGCAGTGGATGATGATGGCGAGGATTCGCCGTCTCCGCCACCGCAGTCGCCGCCGCCGACGGCTCTACCGCTACCTTTCTGGGGCGGCGGACGGGTACCCGGCGGAGCGCAAGCTCGGAAAAGACAGTTCGACGTGGCTTCCTTGCTGGCGCCCGACGAGGCGCCGGAGAAGCGCGTGCGAAGGGACAGCAGCTGCGAGGAGGAAGCCGAGGAGGACATAGACGTGGTGGCGAGCGACCAGGAGGAGCGCGCGGAGGAGGAGGCGCGGGTGGTGGCACCCGCGGCCCACTACCCGCTGCTGGGCGGCTGGTGGCCGGCGCTGGACCCCGCGCTGCTGCAGCAGCTGCGCCGCcacgccgcgcccgcgccctcGCCCCCCAGCCCCACCGACCAGCAGCGGCCACCGGACACCTAA
Protein Sequence
MCSGAEGGSWPLGKDAPAVTAAAIDHYRLQLYNYAVAERLRLYPPAVAPCYGPYAPRLALSMSLLQQRALQPEEPKPQHSYIGLIAMAILSSPERKLVLSDIYQHILDNYPYFRSRGPGWRNSIRHNLSLNDCFVKAGRSANGKGHYWAIHPANIEDFRKGDFRRRKAQRKVRKHMGLAVDDDGEDSPSPPPQSPPPTALPLPFWGGGRVPGGAQARKRQFDVASLLAPDEAPEKRVRRDSSCEEEAEEDIDVVASDQEERAEEEARVVAPAAHYPLLGGWWPALDPALLQQLRRHAAPAPSPPSPTDQQRPPDT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00172548;
90% Identity
iTF_00256668; iTF_00255633; iTF_00651549; iTF_01281121; iTF_00172548; iTF_01061697; iTF_00040610; iTF_00237282; iTF_01064450; iTF_01084066; iTF_00745443; iTF_00043300; iTF_00363844; iTF_00622628; iTF_00757956; iTF_01531780; iTF_00448837; iTF_01440805; iTF_00425190; iTF_00830983; iTF_00905930; iTF_01062570; iTF_01063564; iTF_01532844; iTF_00711630; iTF_00042447; iTF_00907696; iTF_00038513; iTF_00120306; iTF_01246642; iTF_01526834; iTF_01092883; iTF_00071220; iTF_00809876; iTF_01534612; iTF_01525749; iTF_00124054; iTF_00726102; iTF_00924406; iTF_01533750; iTF_00274263; iTF_00036440; iTF_01192440; iTF_00037593; iTF_00808921; iTF_01084954; iTF_00039611; iTF_00041595; iTF_00928475; iTF_01094715; iTF_00122173; iTF_00906877; iTF_00121214; iTF_00123166; iTF_00373727; iTF_00685247; iTF_01093855; iTF_01339775; iTF_01338304; iTF_01439712; iTF_00345633; iTF_00973537; iTF_01280001; iTF_01025796; iTF_00888033; iTF_01030949; iTF_01029033; iTF_01027116; iTF_00185127; iTF_00185956; iTF_00850410; iTF_00771691; iTF_00851534; iTF_01119095; iTF_01118073; iTF_00111418; iTF_01116987; iTF_00299966; iTF_01487530; iTF_00147117; iTF_01028077; iTF_00889007; iTF_01491695; iTF_01501903; iTF_00706760; iTF_01503664; iTF_01502787; iTF_00374993; iTF_00408210; iTF_00072065; iTF_00347331; iTF_00751843; iTF_00960751; iTF_00449939; iTF_01342036; iTF_00171575; iTF_00364728; iTF_00364729; iTF_01538555; iTF_01071455; iTF_00446932; iTF_00445925; iTF_00326902; iTF_01029974; iTF_01282038; iTF_01230327; iTF_00794137; iTF_00951610; iTF_00176924; iTF_00301916; iTF_00300985; iTF_00444926; iTF_01221310; iTF_01362303; iTF_01124416; iTF_01125260; iTF_00025093; iTF_00287878; iTF_01359535; iTF_01152859; iTF_00075275; iTF_00832721; iTF_01436835; iTF_00074294; iTF_00076269; iTF_00931039; iTF_00932234; iTF_00006108; iTF_01081400; iTF_00278929; iTF_00673310;
80% Identity
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