Acra027044.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Archips crataeganus
Gene Symbol
MBD3
Assembly
GCA_947859365.1
Location
OX402060.1:8332845-8338243[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.1e-27 8.4e-24 83.6 0.1 2 72 6 71 5 75 0.93
2 2 0.00025 1 9.6 0.0 29 74 93 146 78 149 0.86

Sequence Information

Coding Sequence
ATGAATATCTCAATTGAAAAGAGGCGGTCGGAGTGTCCGGCATTGCCCAAAGGTTGGCAAAGGGAAGAAGTCTTGAGAAAAACCGGATTATCGGCAGGGAAAGTTGATGTTTATTATTACAGCCCTACAGGTAAAAAGTTTCGCAGTAAGCCAGAGCTAGTGCGTTATCTGGGTGATAGTATGGACCTTTCGTGTTTCGACTTTCAACAGGGTCAGATTAACACGATGCTGCTGTGCAAGGCCAAGAAAGCACGAGCGCAGTTTGATTACAGAGGTGTCCGTTCAGATGCGTCGCTCGTGCCGCCTATCCGTCAAACGGCTTCCATCTTCAAGCAGCCAGTGACTGTATATAAAACTCAGGAAAGCAAGGTGAAGACTGACCTGAAACACGGTACTCAGGAAAAGCCCAAACAACTGTTCTGGGAGAAGAGGCTGGAGGGTTTAACAGCGTGCGACGCGAACGGCGTTATAGGGACAACATCCCTCCCTAAATACATCAAACCACTTGGTCCATATATCTCTGATGCAACCACCATCCAATCACTGGCCACAGCGCTTCACGTGTCATCTCAGTCTATTACTGGCAAGTTTGATTCTAATCTGATGTACCAAATAGAGAAGTAG
Protein Sequence
MNISIEKRRSECPALPKGWQREEVLRKTGLSAGKVDVYYYSPTGKKFRSKPELVRYLGDSMDLSCFDFQQGQINTMLLCKAKKARAQFDYRGVRSDASLVPPIRQTASIFKQPVTVYKTQESKVKTDLKHGTQEKPKQLFWEKRLEGLTACDANGVIGTTSLPKYIKPLGPYISDATTIQSLATALHVSSQSITGKFDSNLMYQIEK