Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 5.6e-29 6.1e-25 87.9 0.1 1 72 8 74 8 78 0.95

2 2 0.00051 5.5 7.9 0.1 29 74 96 149 81 152 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	5.6e-29	6.1e-25	87.9	0.1	1	72	8	74	8	78	0.95
2	2	0.00051	5.5	7.9	0.1	29	74	96	149	81	152	0.86

Coding Sequence: ATGCAGAATATGAACATTTCAATAGAGAGAAAAAGATCCGATTGTTCGGCCTTGCCAAAAGGATGGCAAAGAGAAGAGGTTCTGAGAAAAACAGGACTTTCTGCTGGAAAAGTCGATGTATTTTATTACAGCCCTACAGGTAAAAAGTTTCGCAGTAAACCAGAACTAGTTCGATATCTGGGTGATAGTATGGACCTGTCATGTTTCGACTTTCAACAGGGCCAAATAAACACAATGCTCCTGTGCAAGACCAAGAAAGCACGAGCGCAGTTTGACTACAGAGGAGTACGCTCTGACTCATCTCTGGTGCCACCTATTCGCCAGACAGCGTCCATTTTTAAGCAGCCAGTAACAGTATATAAAACTCAGGAGAGTAAAGTGAAAACAGATCTGAAACAAGGTACACAAGAGAAGCCTAAACAGTTATTTTGGGAAAAACGCTTGGAGAATTTGACTGCATGTGATGCAAATGGTGTTATAGGAACAACAACACTGCCAAAGTACATAAAACCTTTGGGTCCGTTTACAACTGATGCAACCACCATACAGTCTCTGGCTACAGCTCTCCATGTTTCATCACAGCCTATTACAGGACAAACAGGATCAAAGCAAACCATAATGGAAAACCCGGGGCAAAGGAAATAG
Protein Sequence: MQNMNISIERKRSDCSALPKGWQREEVLRKTGLSAGKVDVFYYSPTGKKFRSKPELVRYLGDSMDLSCFDFQQGQINTMLLCKTKKARAQFDYRGVRSDSSLVPPIRQTASIFKQPVTVYKTQESKVKTDLKQGTQEKPKQLFWEKRLENLTACDANGVIGTTTLPKYIKPLGPFTTDATTIQSLATALHVSSQPITGQTGSKQTIMENPGQRK

Sequence clustering based on sequence similarity using MMseqs2