Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 4.5e-25 9.3e-22 77.2 16.0 2 69 59 127 58 128 0.94

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	4.5e-25	9.3e-22	77.2	16.0	2	69	59	127	58	128	0.94

Coding Sequence: ATGGGCCTACCACCGCCTTACGAGCAATCACACCCAAACCCAGCGCCACCGCCGTCGTACTTTGGCGATAACCCTCCGCCTCCTCCCGGGTTCGTGGCCCCCGCGACGGCCCCGAGGACCACGGTCATCACGAACCCCACGCCTAGCGCCGGCCCTGCCGTAAAGCTGGGCCCAGGGCCTACAGGCACCACCTGCGCGTCCTGCAATAGGACTATCGTCACAAGAGTCGACTATGTGCCTAATAACAGAACCCATATCGTGTCGGCTGCGCTTTGTGTTTTAGCTGGATGTTGCTGTGGCTGCTTCGTACCGTACTGCATGAGGTCGTGCAAGACGGCGAACCACTACTGCCCGAAGTGCCGGGCCTTCGTCGGCTCCTATACGCCCTCGTGA
Protein Sequence: MGLPPPYEQSHPNPAPPPSYFGDNPPPPPGFVAPATAPRTTVITNPTPSAGPAVKLGPGPTGTTCASCNRTIVTRVDYVPNNRTHIVSAALCVLAGCCCGCFVPYCMRSCKTANHYCPKCRAFVGSYTPS

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00186806;
90% Identity: iTF_00635079; iTF_00827661; iTF_00045053; iTF_00667042; iTF_00206665; iTF_00936244; iTF_00207515; iTF_00034386; iTF_00033491;
80% Identity: -