Basic Information

Insect: Apis mellifera
Gene Symbol: znf423
Assembly: GCA_003254395.2
Location: NC:6666177-6683569[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 21 5.8e-06 0.00035 20.0 1.5 1 23 92 114 92 114 0.98

2 21 0.33 20 5.0 3.9 1 23 120 142 120 142 0.97

3 21 7.2e-07 4.4e-05 22.8 4.3 1 23 148 170 148 170 0.99

4 21 0.00015 0.0094 15.5 0.2 1 23 176 198 176 198 0.99

5 21 8.6e-05 0.0052 16.3 0.6 1 23 351 374 351 374 0.96

6 21 0.29 18 5.2 0.0 2 23 385 407 384 407 0.88

7 21 0.14 8.7 6.2 0.1 3 23 472 492 471 492 0.97

8 21 0.0041 0.25 11.0 0.8 1 23 504 526 504 526 0.97

9 21 0.0099 0.6 9.8 0.3 1 23 535 558 535 558 0.92

10 21 1.2 70 3.3 0.2 1 23 563 586 563 586 0.91

11 21 3.7 2.3e+02 1.7 0.3 10 23 618 632 616 632 0.93

12 21 0.077 4.7 7.0 2.1 2 23 660 681 660 681 0.96

13 21 0.0065 0.4 10.4 0.1 1 23 686 709 686 710 0.94

14 21 0.89 54 3.7 0.2 2 23 774 797 773 797 0.83

15 21 0.00013 0.0077 15.8 1.1 2 23 813 835 812 835 0.96

16 21 0.029 1.8 8.3 1.0 1 23 844 867 844 867 0.93

17 21 0.00098 0.06 13.0 0.1 2 23 1055 1077 1054 1077 0.95

18 21 0.031 1.9 8.2 0.4 1 23 1087 1110 1087 1110 0.96

19 21 1.9 1.2e+02 2.6 0.4 2 23 1123 1144 1122 1144 0.93

20 21 0.33 20 5.0 0.1 2 23 1153 1175 1152 1175 0.93

21 21 0.028 1.7 8.4 2.6 1 23 1182 1205 1182 1205 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	21	5.8e-06	0.00035	20.0	1.5	1	23	92	114	92	114	0.98
2	21	0.33	20	5.0	3.9	1	23	120	142	120	142	0.97
3	21	7.2e-07	4.4e-05	22.8	4.3	1	23	148	170	148	170	0.99
4	21	0.00015	0.0094	15.5	0.2	1	23	176	198	176	198	0.99
5	21	8.6e-05	0.0052	16.3	0.6	1	23	351	374	351	374	0.96
6	21	0.29	18	5.2	0.0	2	23	385	407	384	407	0.88
7	21	0.14	8.7	6.2	0.1	3	23	472	492	471	492	0.97
8	21	0.0041	0.25	11.0	0.8	1	23	504	526	504	526	0.97
9	21	0.0099	0.6	9.8	0.3	1	23	535	558	535	558	0.92
10	21	1.2	70	3.3	0.2	1	23	563	586	563	586	0.91
11	21	3.7	2.3e+02	1.7	0.3	10	23	618	632	616	632	0.93
12	21	0.077	4.7	7.0	2.1	2	23	660	681	660	681	0.96
13	21	0.0065	0.4	10.4	0.1	1	23	686	709	686	710	0.94
14	21	0.89	54	3.7	0.2	2	23	774	797	773	797	0.83
15	21	0.00013	0.0077	15.8	1.1	2	23	813	835	812	835	0.96
16	21	0.029	1.8	8.3	1.0	1	23	844	867	844	867	0.93
17	21	0.00098	0.06	13.0	0.1	2	23	1055	1077	1054	1077	0.95
18	21	0.031	1.9	8.2	0.4	1	23	1087	1110	1087	1110	0.96
19	21	1.9	1.2e+02	2.6	0.4	2	23	1123	1144	1122	1144	0.93
20	21	0.33	20	5.0	0.1	2	23	1153	1175	1152	1175	0.93
21	21	0.028	1.7	8.4	2.6	1	23	1182	1205	1182	1205	0.97

Sequence Information

Coding Sequence: ATGTTGTTCAAGGGAAATAGTTCGAGATTGGAGTTGTTAATAGGGAAAATCCAGGCACACAAGGAGCCTTCTCAGGAGGAGCAGCAAAAGTCCAAagAGGCGTTGGGGACCGGAAGCTCGTCGTGGCAGAGCGAGGATGGCGGACCAAACTCGCGGCGAGGCGGCGAGACGCCCTCGTCTTGCGCGACCCCGACGTCGGCCAGTTTCCCGTCGGAGCCAGAGGTCGACGCCGACGTCGGAGTGAACGCCGACGGGAGCAACGCGACAGCCCCTTACCCCTGCCAATTCTGCGACCGCACGTTCCCCCGGCTTAGCTATCTCAAGAAGCACGAACAGAGTCACGGGGACCAAATGCCATACAGGTGCAGCTGGTGTGCCAGATTGTTCAAACATAAACGCAGCAGAGATCGACACGTGAAGCTTCACACAGGAGACCGAAGATATCGATGCACGCACTGCGAGGCTGCTTTCTCCAGGAGcgaCCATCTGAAGATCCATATGAAAACGCACGACACGCAGAAACCGTATCAGTGCACGGCCTGTTCCAGAGGGTACAACACGGCAGCTGCCTTGACGTCCCACATGCAATCTCACAAGAAACACCATCAATCGCAAGGATCGACCAAGGACATCGATTACGGTAGAAGAAGCGTGTCCTCTCACAGTACATCATCGCCACCGGTGCCGAGTTCCCCGTCACCGTCATTGAACCTCGCCTTGAACCCGAAACCCGGGTTGAAAAGCTCGCAGGGAAGCGCTTCGACGACGCCAATCCTAAATTCCCCGTTGAAATTGGCCTGCATGTACTGCACCAGAGATTCGTTCAACTGCATGCAACAACTCCAGATGCACGTGCACACGATGCATCAAGCTATCTTGAGCGGGGAAACTGTTGCCGTATCCCCGTCGACGCATAGAGGCAGCGAGCCGATTGGTTATCAGCACGGTGAGAAAAATTCAGACCGATCGGAAGGAACTTCGAAGGAGCACAGGAAGTATCGAGAAGATGATTCGGAGAGGTCTATGGAAAAGGATCATTACGAAAACGCGTTCACGTGCAATCAGTGTACCATGAAATTCTCCACGTTAGGCTCTTTGAGGGATCACTTGATCTCGATCCATAGGACGGACAGTTTCAATTCTGCCTTGATGATGTGCCCCCTTTGCGGCATACCCTGCGCTTCGGCAGCCGCTTACGCGGAACATTACGTTCTTCAACATTGTGAGAATCGATCGATAGGTCCACTGGAGAGCAAAGATTATATGGATGCGAAGATGAACGGTAATTACGAGTCGAAAAGTTCCAGGAATCAGAAATGCAGAGAACAAATATCTTGTTCTGCAGAGCCGGCAGACTTGACTAGCAAGCATACCGCTACTACGGAAAACAATTATTCAGCTGGTACTCTGTTATGCGGCCAATGTGGAGCAGCTTTAAAGGACTTTGAATCTTTCAGAGAACATCTGGCCAGACACCTTCAAGCTAATCATAGAAACGATGCTGTCAGACATTCTTGTCCCAAGTGTGAGGCCACTTTCCAAGACAGGGAAGACATGTTGGTGCACTTGACAAAGCATTATCTGGGCCAGATTAGCAAAGAGTATGCCTGTGGTGCCTGCAAAAAGCTTTATCCCCATCCAGATCTTCTTCAAAGGCACTTGCTCGATAGTCACGCTCACCACCTTTACAGATGCGCTCTCTGTAAAGACACTTTTGATTCCAGAGTGGCGATACAAGTCCATTTTGCTGTGAAACACAGTCAAGAATGCAGGATCTATAGGTGCAATGCTTGTACGGTGTCCAATAACGAAAATTCGCCGGGTAATGCGCCAGGTGAAGGGAAAAGTTTCTTCAGGAGTGAATCAGAGATGACAAATCATGTGAGAAATGTCCATGCGCCTCCTACTGTATCAAATAACAGCCCTGTAGCCAGAAGCCCCGCATCTACTCCTGGAATAACTGGAAATTCCGGACCGAGATGTGTCTTCTGTGGAATTTGTTGTACCTCTGAACTGGAATTACAACTCCATTTGGCTAGCCATTCTGTTAACTTGTACAGATGTCCAGTTTGTAGAGAGGGATTTGCTGTAGAATTTTTGCTGGACAGGCATATTGCTCAAGCGCATCATTCCAGTAATCATCAAGGTATTATTAGAAGTAGCTCTAGAGAAAATGGAAGGATTGGTAGACCGCCAAGATTGCAAGAAGAGacaAAATCTCAAAAAAGAGGTCGTTCTCCAGCCTCCAGCAACAACAACACCGTAAATCAACGAGACAACAATAATAAACGTCCAAATTACTCCAACACATCTTCTCAACAGTGTGATCTCTGCGAAAGAGGGGAATTTTCTAATGAAACAGAACTCCAAGCCCACAAGAAATTGGTTCACACTCCGGCcaagtttcaaaataaatcctTATCAAATCTCAGCATGACTTGCGCATATTGTGGAGAAGTATGTCGTTCTAGAACTGATCTGGAATCTCATACAAGGATTCAACATGCATCGAATGAACCTGGGGGCCGCCACAAATGCAATATTTGTGACGAAGTCTGTCCTTCAGGTGCAACTCTGGCAGAGCATAAACTGCAAAAACACTGTAAAATTCAACTAAGTGACACGTGTATTGTTTGTCGAGGAAATTTAGCCTCGGAATCACAGTTTTTAGAACACGTTCAAAGACACAGTTTGGAAAACGTGGATCCACAACAGAGATTGGACGGTTCTCTTCCCCATCTTCCTGCTGCGTGTGTAGTTTGCAGACAGACGCTGATCAGCGATTTGGAATGTCGCCTTCATGCCAGACATCATTTGAGAGCTTCTACTGGTGCTCACAGTGTGGGATCTAGCCCTAGTCCCAATCAAAAAAATCAGAATCCAAGTTGTTGTCTTTGCTTAAGAGATTTTTCTAGCGATGACTTTGTTAATTTGCCTCCAAGTCATGTGAGTGGAGGAGGACAATCTTTGAGGGTCTGCAAATCTTGCTATATTCGTCATTCTCAAGGTTTACCTATTTTGAATTCATATGAATCTGTTAGATCTAAATGTGATGATTCTTGGAcatctaataataaagatgGACAATGGGATGGGTCGAAAAATAAATGGGAATcggagaataaatataaagagaataGAAATGGAATGATTGATAATAAGAGATGTCAAGATTGTGGAGTGAAATTTGAGGATTCCGAAGAGGTGGAAAAGCATAGGATAATAGAGCATGAGAAGACTGGAACTGCATCTAATACGTATACGTGTATACAATgtcaaATGTCATTCGCAACGGAAGCAAAGATTCAACAGcatataaagaaagaacatTTGGAAGTAGCAGGAAAAACTTCCATGGAGGCATTACGATGTCATCTATGTCTATTTGAAGCTAATAGTCCATTGCAGTTGCAAAGCCATTTGATAGAACATACTTTTGCAGGATGTGCCGCTCTCAGCTGTTATATTTGCCAATCTCTTTTCACTGCACCTATTGGTCTTCAGaatcataTGCTTCAAGAACACGGTTTGGGTGCACGCCCGTATGATTGTTCCCAGtgcacattaaaatttttcttcagagCAGAATTGGATCATCATATATTAACATTCCATCGATCTGGAGACGTATCCTCGCCTGATGAAGATATACAAAACAACATTGAAACGAAACCAAGAGACACCGAAGAAAATAACTGTGACGAAAGAATAATGGTGAAAGAAGAATTGTTACCGGAAGCTgcagacgaagaagaagagatcaACGTGGATGAACAAGTAGAAGAGAACGAGCAAAAGGAAGACAAACAGTTAGAATTCGagacaaaattaaaaactgaaaTCGAGGAGGAAAACATTCTCCAGTCTTCTATTTCCGAGAAGATGGAATCGTGA
Protein Sequence: MLFKGNSSRLELLIGKIQAHKEPSQEEQQKSKEALGTGSSSWQSEDGGPNSRRGGETPSSCATPTSASFPSEPEVDADVGVNADGSNATAPYPCQFCDRTFPRLSYLKKHEQSHGDQMPYRCSWCARLFKHKRSRDRHVKLHTGDRRYRCTHCEAAFSRSDHLKIHMKTHDTQKPYQCTACSRGYNTAAALTSHMQSHKKHHQSQGSTKDIDYGRRSVSSHSTSSPPVPSSPSPSLNLALNPKPGLKSSQGSASTTPILNSPLKLACMYCTRDSFNCMQQLQMHVHTMHQAILSGETVAVSPSTHRGSEPIGYQHGEKNSDRSEGTSKEHRKYREDDSERSMEKDHYENAFTCNQCTMKFSTLGSLRDHLISIHRTDSFNSALMMCPLCGIPCASAAAYAEHYVLQHCENRSIGPLESKDYMDAKMNGNYESKSSRNQKCREQISCSAEPADLTSKHTATTENNYSAGTLLCGQCGAALKDFESFREHLARHLQANHRNDAVRHSCPKCEATFQDREDMLVHLTKHYLGQISKEYACGACKKLYPHPDLLQRHLLDSHAHHLYRCALCKDTFDSRVAIQVHFAVKHSQECRIYRCNACTVSNNENSPGNAPGEGKSFFRSESEMTNHVRNVHAPPTVSNNSPVARSPASTPGITGNSGPRCVFCGICCTSELELQLHLASHSVNLYRCPVCREGFAVEFLLDRHIAQAHHSSNHQGIIRSSSRENGRIGRPPRLQEETKSQKRGRSPASSNNNTVNQRDNNNKRPNYSNTSSQQCDLCERGEFSNETELQAHKKLVHTPAKFQNKSLSNLSMTCAYCGEVCRSRTDLESHTRIQHASNEPGGRHKCNICDEVCPSGATLAEHKLQKHCKIQLSDTCIVCRGNLASESQFLEHVQRHSLENVDPQQRLDGSLPHLPAACVVCRQTLISDLECRLHARHHLRASTGAHSVGSSPSPNQKNQNPSCCLCLRDFSSDDFVNLPPSHVSGGGQSLRVCKSCYIRHSQGLPILNSYESVRSKCDDSWTSNNKDGQWDGSKNKWESENKYKENRNGMIDNKRCQDCGVKFEDSEEVEKHRIIEHEKTGTASNTYTCIQCQMSFATEAKIQQHIKKEHLEVAGKTSMEALRCHLCLFEANSPLQLQSHLIEHTFAGCAALSCYICQSLFTAPIGLQNHMLQEHGLGARPYDCSQCTLKFFFRAELDHHILTFHRSGDVSSPDEDIQNNIETKPRDTEENNCDERIMVKEELLPEAADEEEEINVDEQVEENEQKEDKQLEFETKLKTEIEEENILQSSISEKMES

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00684951;
90% Identity: iTF_00140801; iTF_00142009; iTF_00141384;
80% Identity: -