Basic Information

Insect: Anopheles melas
Gene Symbol: grau
Assembly: GCA_000473525.2
Location: AXCO02015852.1:4342-6716[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 13 6.1 3.3e+02 1.9 0.3 1 9 95 103 95 108 0.88

2 13 2.7 1.5e+02 3.0 0.1 3 23 262 285 260 285 0.79

3 13 2.3e-05 0.0012 19.0 0.4 2 23 293 314 292 314 0.96

4 13 4.4 2.4e+02 2.3 0.6 12 23 370 382 368 382 0.83

5 13 0.0034 0.19 12.1 0.6 2 23 390 411 389 411 0.98

6 13 0.095 5.1 7.6 0.1 9 23 499 514 497 514 0.90

7 13 0.0074 0.4 11.1 0.9 2 23 522 543 521 543 0.96

8 13 1.7e-05 0.00094 19.3 0.3 1 23 574 597 574 597 0.96

9 13 0.0049 0.26 11.6 0.5 3 23 604 624 602 624 0.95

10 13 8.7e-07 4.7e-05 23.4 0.4 1 23 630 652 630 652 0.96

11 13 0.00052 0.028 14.7 0.3 2 23 684 706 683 706 0.96

12 13 3.5e-05 0.0019 18.4 2.2 2 20 713 731 713 733 0.94

13 13 7.4e-05 0.004 17.4 2.7 3 23 742 762 740 762 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	13	6.1	3.3e+02	1.9	0.3	1	9	95	103	95	108	0.88
2	13	2.7	1.5e+02	3.0	0.1	3	23	262	285	260	285	0.79
3	13	2.3e-05	0.0012	19.0	0.4	2	23	293	314	292	314	0.96
4	13	4.4	2.4e+02	2.3	0.6	12	23	370	382	368	382	0.83
5	13	0.0034	0.19	12.1	0.6	2	23	390	411	389	411	0.98
6	13	0.095	5.1	7.6	0.1	9	23	499	514	497	514	0.90
7	13	0.0074	0.4	11.1	0.9	2	23	522	543	521	543	0.96
8	13	1.7e-05	0.00094	19.3	0.3	1	23	574	597	574	597	0.96
9	13	0.0049	0.26	11.6	0.5	3	23	604	624	602	624	0.95
10	13	8.7e-07	4.7e-05	23.4	0.4	1	23	630	652	630	652	0.96
11	13	0.00052	0.028	14.7	0.3	2	23	684	706	683	706	0.96
12	13	3.5e-05	0.0019	18.4	2.2	2	20	713	731	713	733	0.94
13	13	7.4e-05	0.004	17.4	2.7	3	23	742	762	740	762	0.97

Sequence Information

Coding Sequence: ATGGATGCAGCGGCGGCTGTAGCACCACCACCAGCAGCAGCAGCAGCAGCACCGCCACCACCACCACCACCACTGCCGCCAGCCTCGGCGGCAGCAGCACCACCACCACCGAACAGTGTTTACGATGTCATCAATCAAAAGGAATGCGGACTGTGTCTCACGCTCCGGGCGGAGCAGATCTGCTTCGACATGTTCATGCCGCGGGAGGACGACCCGAAGGAGATGCCGTATCTGGTGTGGAAGCACGTCGGGCTACAGTTTCCGCAGGAGGCAGGCAAACACTACGTCTGCCGGGACTGCGGGTACGCGGTGTACGAGTTTAACCGATTCTACTTGATGGTGCAGAACGTCCACCAGGAACGGCAGGCTGCAGCAGCGGCAGCAGTACTGCAACCGAAGCAAGAGCCGCCTATGCAGGAGCAGGTACAATATAATGCTGAGCAGGCGGCGACGGAAGGCGTCAATCAGAACGGTCATCATGGAGGCGAGCAAAAGTTTGACCCGTCGCCGCTGGTGGACGGACCCATGCCGTTGCTGTCCGATGTACCGGATTATGGGATGAAGCACGAAGTGAACGGAATGCTACCATCCGGCGGATCCGGGGTAACGGCTGTCGGGGGCAACGGTACAGCGGCAGAGTGTCCGTCGGTGTACACGTCGCAGCACAACGATACGGAACCGGAAAGCAGCCGAATCCGGCCGGTCACGGGCAACACACCGAGCAGCCGGAAGCGCCGCAACCAAGAGATGGACGATGAGATTATCGACTTTTACAAGCTGGTCTGTGACGTGTGCGAGGAACGCATCGAGTACGGCACGATGAAGGAGCTGAACCAGCACATGAAGCTGATGCACGGGGAGGAGACGGGCCGGGTCAGCTGTCCGCAGTGTGGCAAAATGTTCCGCACGCGGGGGAAGCTGCTGGAGCACAAGAGCGTGCACCAGCGGCAGGACGCCACGTCCGAGGACGACGCGGAGAAGCTACAGTCCGAGCAGATGGACAAGGAGATACTGGAGTTTTACAAGCGCATCAGCTGCGATGTGTGCGACACGGCGGCCAGTGCTGCTGCCGGGGCCGGTCCACAGGCCAGCGCGATGCTGTACGCGACGGTGAAGGAGCTAAACCACCACATGCGACTGGTGCACGGGCAGCAGGCCGGTACGGTAAAGTGTCCACTGTGTGAGAAGAAGATCCGTACGCGCCCGAAGCTGCTCGAGCACAAGCGCATGCACCAGCCAAACGCGCTGCTGGAGGAAGATTCCGGCAAGTCGGGCAACCCGGGCGGCGAGCCGGGGCCCGAGCTGACCGAGGAGCAGAAGCAGACGCTAGATAGAGAAATATTCGATTTCTACAAACCCATCATATGTGAGATTTGCGATCCGGAAAAGGTCGCTGTGGCTGTCGCGGTGGCCGGCCCCGGCGGTGACCCGGGCGGTGTTGCCGCGGGAGCAGGCCAGCCGGAAGCAGCAGCAGCAGCAACGACCCAAGAGGAGGAGTACCGGTCGCTGAAGCAGCTGAACCAGCACATGCGGACGGTGCACGGGCTCGAGTCGGGCACGGTCAAGTGTCAGCTGTGCGCGAAAAAGTTTCGGTCGCGCGTCAAGCTGGTCGAGCATAAGGATATGCACGAGAATCCGGAGCGGTTCCGGTGCGGCGTGTGCCAGGAGGTGCACCAGAACCTGGAGGAGCACATGCAGAACAAGCACCAGGAGTGGGAGTTTGCTTGCGAGGAGTGCGGCAAGCGGTTTCCTTTCAAGAACAGACTCACTGCCCACATGGCCAAGGTGCACATGAAGAAGGACATTATCTGTGAGGAATGTAACAAACCATTTACAAAGTTCAGCATCGAGAAACACAAGAAAACGGTCCACGGTCACGGTGGGACGTTCATCTGTGAAAACTGCCCGAAAACGTTCAAGACGCGCGTCTCGCTCGAACGACACATGGAGGGGCACAACAACGGGGAGCAGCAGCAGCAGCAGCAGCAACCGCAACCGCAACCGCTGCCACTACCGCTGCCGCAGCAACCGAGCTCTGCCGCGACCGTCAGCTGCTCCCTGTGCAACTCCGTCCTGAAGGACGAGTACAACCTGAAGGCCCACATGAAGCGCATCCACGCGGAGCAGACGCCGGCGACGTGCAACACGTGCGGCAAGACGTTCAAATCGAAGCACAGTCTCAACACGCACACCGCGAACGTGTGCACGACCCGGCTCTTTGGCTGCACGACCTGCGGCAAGCAGTTTAAGAAGCGGACAAAGTTGAAACAACACATGACGATTCACCCACGCGGCGCCGACTAA
Protein Sequence: MDAAAAVAPPPAAAAAAPPPPPPPLPPASAAAAPPPPNSVYDVINQKECGLCLTLRAEQICFDMFMPREDDPKEMPYLVWKHVGLQFPQEAGKHYVCRDCGYAVYEFNRFYLMVQNVHQERQAAAAAAVLQPKQEPPMQEQVQYNAEQAATEGVNQNGHHGGEQKFDPSPLVDGPMPLLSDVPDYGMKHEVNGMLPSGGSGVTAVGGNGTAAECPSVYTSQHNDTEPESSRIRPVTGNTPSSRKRRNQEMDDEIIDFYKLVCDVCEERIEYGTMKELNQHMKLMHGEETGRVSCPQCGKMFRTRGKLLEHKSVHQRQDATSEDDAEKLQSEQMDKEILEFYKRISCDVCDTAASAAAGAGPQASAMLYATVKELNHHMRLVHGQQAGTVKCPLCEKKIRTRPKLLEHKRMHQPNALLEEDSGKSGNPGGEPGPELTEEQKQTLDREIFDFYKPIICEICDPEKVAVAVAVAGPGGDPGGVAAGAGQPEAAAAATTQEEEYRSLKQLNQHMRTVHGLESGTVKCQLCAKKFRSRVKLVEHKDMHENPERFRCGVCQEVHQNLEEHMQNKHQEWEFACEECGKRFPFKNRLTAHMAKVHMKKDIICEECNKPFTKFSIEKHKKTVHGHGGTFICENCPKTFKTRVSLERHMEGHNNGEQQQQQQQPQPQPLPLPLPQQPSSAATVSCSLCNSVLKDEYNLKAHMKRIHAEQTPATCNTCGKTFKSKHSLNTHTANVCTTRLFGCTTCGKQFKKRTKLKQHMTIHPRGAD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00101146;
90% Identity: iTF_00107183; iTF_00095830; iTF_00101146;
80% Identity: -