Amel012858.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Anopheles melas
Gene Symbol
Bcl11b
Assembly
GCA_000473525.2
Location
AXCO02004816.1:16465-19383[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 3.6e-07 1.9e-05 24.6 4.2 1 23 355 377 355 377 0.99
2 15 3.9e-07 2.1e-05 24.5 0.5 1 23 383 405 383 405 0.99
3 15 2.3e-05 0.0013 18.9 0.1 1 23 411 433 411 433 0.98
4 15 3.7e-05 0.002 18.3 0.6 2 23 439 460 438 460 0.96
5 15 3.2e-07 1.7e-05 24.8 4.0 1 23 466 488 466 488 0.99
6 15 3.6e-05 0.0019 18.3 2.5 1 23 558 580 558 580 0.97
7 15 5.9e-06 0.00032 20.8 2.5 2 23 587 608 586 608 0.98
8 15 1.8e-06 9.8e-05 22.4 0.8 1 23 614 636 614 636 0.98
9 15 2.3e-06 0.00012 22.1 0.1 2 23 642 663 641 663 0.98
10 15 1.7e-06 9.2e-05 22.5 2.1 1 23 669 691 669 691 0.99
11 15 1.8e-07 9.6e-06 25.6 2.1 1 23 739 761 739 761 0.99
12 15 3.3e-07 1.8e-05 24.8 0.9 1 23 767 789 767 789 0.99
13 15 4.6e-05 0.0025 18.0 0.3 1 23 795 817 795 817 0.98
14 15 4.3e-06 0.00023 21.2 0.3 2 23 823 844 822 844 0.97
15 15 3e-06 0.00016 21.7 1.2 1 23 850 872 850 872 0.98

Sequence Information

Coding Sequence
ATGTCCACCATCGGTAACTGTGAGCCTAGGGACAAGTGTGATATCTGCAATCGCAACATTGTACAGTCGTTGCCAGAGGAGCAGGCGGCCTATGGCCCCTCGATGACGGCTGGAAGCTCCCCAATGTCTACACAAACCACAGCGTCTGTGCTGTCCGACGGCACGATTGGTGGAACGGTCCACTTGCCAACGATGATAGCGACGCTAACCTCCCCCGAAGTGTCTAACGAAAGCGTCAGCGATCTCAGTGCCAACGTCAATGTAAGGTCTATCGTGAACAGTCCCATCGAACAGCACGACCTAAGCAGCCTGGATCCGTTCGGGTCGGACAGCGAGTGTCTGGGCCAGTTCTTTGCCGCTGAGCCCAGCTCCACCTCGCCCTGTACGGCTAGCAGCACGGCAACCAACTTACAGTGTCAACCAATGCCAACTAGTGCCAACATGGGGAGTCTTCTCTCCATCCCTGCACTGCACCAGCCAGAGTCAGCGAAGACGTACTTCGTGCTTGGAAATGTGGATCAGTTGCAGCAATTTCACGACATAGCAGCACCACCACCAGCAACAGCAGAGCAAGCGCCAGTGCAGCAACCACCAGCCGGCAGCAATCTACCAACACCGGTCACCAATAGCTTCCATCATCTTCATTTAGCGCCAGCAGGACCTGGGCCTCATCAGCAGCAGCAACTGCTACCTCTCTCGCTGCAGAATGCCGCCCCCGCTACGGCCGGTTCGCTTCTGCTCAGCGAGCACGAGGTCACTAGTCTGCAGCAGTACGACCAGTACGATGATGAGGACTACTCGTCCATGTCCGAAGATGAAGCTATTGTTCCAATAGAACCCTATGCCAAATCGCCCAACCAGGACCATGCCAAGACGGAGCTCCCAATCCAAGAGACGATCGTTGACACTAGCACCGGCATCAGTGTCATGTCGCTGCCACCGTTCGGAACTGGCGGACTGCCAAGGGACGCTGATGCGAACGGTGGCGGCGAAAGAAGGCCACATCAGACACAGTCCTCCACTACCACCAGCACCAGCACCAGCACCAACCCCGATCGACCCTACAAGTGCCACATCTGCGACCGTTCGTACCGCAACCAGAAGAACCTGAGGTCCCATCTGAAGGTGCACGAGGGCATTCGGGCGTACCAGTGCGAGATCTGTGGCAAGAATTTCTCCGGCTCCAGCTATCTGGTGATCCACCGGCGGCGCCATACGGGCGAACGGCCATTCAAGTGCGTCACCTGCGGGAAGGCGTTCGTCGATTCGCGAGCGCTGGCCGTGCACGCGCGCTTGCACAGCGGCGAGCGGCTCAAGTGCGAAAAGTGCGAGAAAACTTTCTCCAGCGTGAGTGCCCTGACTGTGCACAATCGGCTGCACACCGGCATACACCCTTACCGGTGTGAGCTGTGTGGCAAAACCTTCCCACAGTACAACAACCTGAAGCACCACATGAAGAAGCACGAGCAACCGAGCGATGCAGAGCAGCTGCTGCCCCAAGCAATGGCGACCTCAACCGGTGGCCCCACACCACCGTCCAATGGGGTGAGCACTACGACGAGCGGCTCCGGCACTGTACTGGCGCGCATCAGTCTCTCCATACAGGCCGACACAACCGGCAAAGGAACGGTGCACATGATAGCCAGCTCGACCACGGGTCCGGCCTCCGAGTACAAATGCCACATCTGCAATAAGCTGTACAAATCCTCCGACGACCTGCAGGAGCACCTGAGCCAGCACAGCAAGGATCGGCCGAACCAGTGCGAGTTTTGCTCGAAAGTGTTTCCGCGCTCTTCGCACCTCATCATCCACCGGCGTCGGCACACGGGCGAGCGGCCCTTCAAGTGCAAATACTGCGACAAAGCGTTCGTTGACTCGCGCGCCCTCTCCGTCCACACGCGCCTGCACACGGGCGAGCGGGTCAAGTGCGAAATCTGTGAGAAAACGTTCGCCAGCTCGAGCGGTCTCATAGTGCACCGGCGCATCCACACGGGGGTGCATCCGTACAAGTGTGACTACTGCGAAAAGTCCTTCGCCCAATCGACGGCACTCAAGTACCATCTGAAAAAGCACGACACCGCCCTGCTGCCAACCACGACCACGCCCGAGGGAGCTGATGCGCGGCTACCAGCCCTGCCCCAGACCGGTGCCGCTGATGTTGGGCCATGTGCGCCCTCGTTTGGCGAGGACGCGACCACGAACGGCAACGACCGGTACAAGTGCACCGTGTGCAACAAAGCTTTCCGATCCTCCGAGTACCTGGTGCGCCATCGTCGGACGCACAGCGGTGAGCGGCCGTACCAGTGCGAGATTTGCGGCAAGAACTTCTCCACCATGAGCTACCTAGTGATCCACCGGCGTCGACACACCTCGGAGCGCCCGTACAAGTGTACCTCCTGCGAGAAAGCGTTTGTCGACTCGCGTGCGCTCCAGGAGCACGCCCGGCTACACACGGGCGATCGGGTGCGTTGTGAGATCTGCCAGAAAACGTACTCCAGCGTCAGCAATCTGATCGTGCACCGGCGCATCCACAGTGGCATTCATCCCTTCGAGTGTGACAGCTGTGGCAAATCGTTTGCGCAGAAAAATGCCCTCAAATATCACCTCAAGAAGCACGCCGAAACGCACAAGAAACAGGAGCAGCCAGAGCCCGTCGGTTAG
Protein Sequence
MSTIGNCEPRDKCDICNRNIVQSLPEEQAAYGPSMTAGSSPMSTQTTASVLSDGTIGGTVHLPTMIATLTSPEVSNESVSDLSANVNVRSIVNSPIEQHDLSSLDPFGSDSECLGQFFAAEPSSTSPCTASSTATNLQCQPMPTSANMGSLLSIPALHQPESAKTYFVLGNVDQLQQFHDIAAPPPATAEQAPVQQPPAGSNLPTPVTNSFHHLHLAPAGPGPHQQQQLLPLSLQNAAPATAGSLLLSEHEVTSLQQYDQYDDEDYSSMSEDEAIVPIEPYAKSPNQDHAKTELPIQETIVDTSTGISVMSLPPFGTGGLPRDADANGGGERRPHQTQSSTTTSTSTSTNPDRPYKCHICDRSYRNQKNLRSHLKVHEGIRAYQCEICGKNFSGSSYLVIHRRRHTGERPFKCVTCGKAFVDSRALAVHARLHSGERLKCEKCEKTFSSVSALTVHNRLHTGIHPYRCELCGKTFPQYNNLKHHMKKHEQPSDAEQLLPQAMATSTGGPTPPSNGVSTTTSGSGTVLARISLSIQADTTGKGTVHMIASSTTGPASEYKCHICNKLYKSSDDLQEHLSQHSKDRPNQCEFCSKVFPRSSHLIIHRRRHTGERPFKCKYCDKAFVDSRALSVHTRLHTGERVKCEICEKTFASSSGLIVHRRIHTGVHPYKCDYCEKSFAQSTALKYHLKKHDTALLPTTTTPEGADARLPALPQTGAADVGPCAPSFGEDATTNGNDRYKCTVCNKAFRSSEYLVRHRRTHSGERPYQCEICGKNFSTMSYLVIHRRRHTSERPYKCTSCEKAFVDSRALQEHARLHTGDRVRCEICQKTYSSVSNLIVHRRIHSGIHPFECDSCGKSFAQKNALKYHLKKHAETHKKQEQPEPVG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00105277;
90% Identity
iTF_00104526; iTF_00095774;
80% Identity
iTF_00104526;