Basic Information

Insect: Anopheles melas
Gene Symbol: Bcl11b
Assembly: GCA_000473525.2
Location: KI922553.1:573-3848[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 16 0.00015 0.0083 16.3 2.1 1 21 30 50 30 51 0.95

2 16 3.9e-07 2.1e-05 24.5 4.2 1 23 427 449 427 449 0.99

3 16 4.2e-07 2.3e-05 24.4 0.5 1 23 455 477 455 477 0.99

4 16 2.6e-05 0.0014 18.8 0.1 1 23 483 505 483 505 0.98

5 16 4e-05 0.0022 18.2 0.6 2 23 511 532 510 532 0.96

6 16 3.5e-07 1.9e-05 24.6 4.0 1 23 538 560 538 560 0.99

7 16 3.9e-05 0.0021 18.2 2.5 1 23 630 652 630 652 0.97

8 16 6.4e-06 0.00034 20.7 2.5 2 23 659 680 658 680 0.98

9 16 2e-06 0.00011 22.3 0.8 1 23 686 708 686 708 0.98

10 16 2.5e-06 0.00014 22.0 0.1 2 23 714 735 713 735 0.98

11 16 1.9e-06 0.0001 22.4 2.1 1 23 741 763 741 763 0.99

12 16 1.9e-07 1e-05 25.5 2.1 1 23 811 833 811 833 0.99

13 16 3.6e-07 1.9e-05 24.6 0.9 1 23 839 861 839 861 0.99

14 16 5e-05 0.0027 17.9 0.3 1 23 867 889 867 889 0.98

15 16 4.7e-06 0.00025 21.1 0.3 2 23 895 916 894 916 0.97

16 16 3.3e-06 0.00018 21.6 1.2 1 23 922 944 922 944 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	16	0.00015	0.0083	16.3	2.1	1	21	30	50	30	51	0.95
2	16	3.9e-07	2.1e-05	24.5	4.2	1	23	427	449	427	449	0.99
3	16	4.2e-07	2.3e-05	24.4	0.5	1	23	455	477	455	477	0.99
4	16	2.6e-05	0.0014	18.8	0.1	1	23	483	505	483	505	0.98
5	16	4e-05	0.0022	18.2	0.6	2	23	511	532	510	532	0.96
6	16	3.5e-07	1.9e-05	24.6	4.0	1	23	538	560	538	560	0.99
7	16	3.9e-05	0.0021	18.2	2.5	1	23	630	652	630	652	0.97
8	16	6.4e-06	0.00034	20.7	2.5	2	23	659	680	658	680	0.98
9	16	2e-06	0.00011	22.3	0.8	1	23	686	708	686	708	0.98
10	16	2.5e-06	0.00014	22.0	0.1	2	23	714	735	713	735	0.98
11	16	1.9e-06	0.0001	22.4	2.1	1	23	741	763	741	763	0.99
12	16	1.9e-07	1e-05	25.5	2.1	1	23	811	833	811	833	0.99
13	16	3.6e-07	1.9e-05	24.6	0.9	1	23	839	861	839	861	0.99
14	16	5e-05	0.0027	17.9	0.3	1	23	867	889	867	889	0.98
15	16	4.7e-06	0.00025	21.1	0.3	2	23	895	916	894	916	0.97
16	16	3.3e-06	0.00018	21.6	1.2	1	23	922	944	922	944	0.98

Sequence Information

Coding Sequence: ATGCGCTTCGAAACATTCGGAAGCGATTACGCAAAGTCCCAGCTGACGGCGGCTGCCAACCGGATATCGCTGACCGGCGATCACTCCTTCCAGTGCGAGTTTTGCGGGGAGGGATTCTCCACCCAGACCAGCTTCAACCGGCATCGGTGCGGGAGTACAGACATCCAGATATACCGGTGCGAAAATTGCCGCCAGGAGTATGGAAGCTCGCGTGCCATGTCCACCATCGGTAACTGTGAGCCTAGGGACAAGTGTGATATCTGCAATCGCAACATTGTACAGTCGTTGCCAGAGGAGCAGGCGGCCTATGGCCCCTCGATGACGGCTGGAAGCTCCCCAATGTCTACACAAACCACAGCGTCTGTGCTGTCCGACGGCACGATTGGTGGAACGGTCCACTTGCCAACGATGATAGCGACGCTAACCTCCCCCGAAGTGTCTAACGAAAGCGTCAGCGATCTCAGTGCCAACGTCAATGTAAGGTCTATCGTGAACAGTCCCATCGAACAGCACGACCTAAGCAGCCTGGATCCGTTCGGGTCGGACAGCGAGTGTCTGGGCCAGTTCTTTGCCGCTGAGCCCAGCTCCACCTCGCCCTGTACGGCTAGCAGCACGGCAACCAACTTACAGTGTCAACCAATGCCAACTAGTGCCAACATGGGGAGTCTTCTCTCCATCCCTGCACTGCACCAGCCAGAGTCAGCGAAGACGTACTTCGTGCTTGGAAATGTGGATCAGTTGCAGCAATTTCACGACATAGCAGCACCACCACCAGCAACAGCAGAGCAAGCGCCAGTGCAGCAACCACCAGCCGGCAGCAATCTACCAACACCGGTCACCAATAGCTTCCATCATCTTCATTTAGCGCCAGCAGGACCTGGGCCTCATCAGCAGCAGCAACTGCTACCTCTCTCGCTGCAGAATGCCGCCCCCGCTACGGCCGGTTCGCTTCTGCTCAGCGAGCACGAGGTCACTAGTCTGCAGCAGTACGACCAGTACGATGATGAGGACTACTCGTCCATGTCCGAAGATGAAGCTATTGTTCCAATAGAACCCTATGCCAAATCGCCCAACCAGGACCATGCCAAGACGGAGCTCCCAATCCAAGAGACGATCGTTGACACTAGCACCGGCATCAGTGTCATGTCGCTGCCACCGTTCGGAACTGGCGGACTGCCAAGGGACGCTGATGCGAACGGTGGCGGCGAAAGAAGGCCACATCAGACACAGTCCTCCACTACCACCAGCACCAGCACCAGCACCAACCCCGATCGACCCTACAAGTGCCACATCTGCGACCGTTCGTACCGCAACCAGAAGAACCTGAGGTCCCATCTGAAGGTGCACGAGGGCATTCGGGCGTACCAGTGCGAGATCTGTGGCAAGAATTTCTCCGGCTCCAGCTATCTGGTGATCCACCGGCGGCGCCATACGGGCGAACGGCCATTCAAGTGCGTCACCTGCGGGAAGGCGTTCGTCGATTCGCGAGCGCTGGCCGTGCACGCGCGCTTGCACAGCGGCGAGCGGCTCAAGTGCGAAAAGTGCGAGAAAACTTTCTCCAGCGTGAGTGCCCTGACTGTGCACAATCGGCTGCACACCGGCATACACCCTTACCGGTGTGAGCTGTGTGGCAAAACCTTCCCACAGTACAACAACCTGAAGCACCACATGAAGAAGCACGAGCAACCGAGCGATGCAGAGCAGCTGCTGCCCCAAGCAATGGCGACCTCAACCGGTGGCCCCACACCACCGTCCAATGGGGTGAGCACTACGACGAGCGGCTCCGGCACTGTACTGGCGCGCATCAGTCTCTCCATACAGGCCGACACAACCGGCAAAGGAACGGTGCACATGATAGCCAGCTCGACCACGGGTCCGGCCTCCGAGTACAAATGCCACATCTGCAATAAGCTGTACAAATCCTCCGACGACCTGCAGGAGCACCTGAGCCAGCACAGCAAGGATCGGCCGAACCAGTGCGAGTTTTGCTCGAAAGTGTTTCCGCGCTCTTCGCACCTCATCATCCACCGGCGTCGGCACACGGGCGAGCGGCCCTTCAAGTGCAAATACTGCGACAAAGCGTTCGTTGACTCGCGCGCCCTCTCCGTCCACACGCGCCTGCACACGGGCGAGCGGGTCAAGTGCGAAATCTGTGAGAAAACGTTCGCCAGCTCGAGCGGTCTCATAGTGCACCGGCGCATCCACACGGGGGTGCATCCGTACAAGTGTGACTACTGCGAAAAGTCCTTCGCCCAATCGACGGCACTCAAGTACCATCTGAAAAAGCACGACACCGCCCTGCTGCCAACCACGACCACGCCCGAGGGAGCTGATGCGCGGCTACCAGCCCTGCCCCAGACCGGTGCCGCTGATGTTGGGCCATGTGCGCCCTCGTTTGGCGAGGACGCGACCACGAACGGCAACGACCGGTACAAGTGCACCGTGTGCAACAAAGCTTTCCGATCCTCCGAGTACCTGGTGCGCCATCGTCGGACGCACAGCGGTGAGCGGCCGTACCAGTGCGAGATTTGCGGCAAGAACTTCTCCACCATGAGCTACCTAGTGATCCACCGGCGTCGACACACCTCGGAGCGCCCGTACAAGTGTACCTCCTGCGAGAAAGCGTTTGTCGACTCGCGTGCGCTCCAGGAGCACGCCCGGCTACACACGGGCGATCGGGTGCGTTGTGAGATCTGCCAGAAAACGTACTCCAGCGTCAGCAATCTGATCGTGCACCGGCGCATCCACAGTGGCATTCATCCCTTCGAGTGTGACAGCTGTGGCAAATCGTTTGCGCAGAAAAATGCCCTCAAATATCACCTCAAGAAGCACGCCGAAACGCACAAGAAACAGGAGCAGCCAGAGCCCGTCGGTTAG
Protein Sequence: MRFETFGSDYAKSQLTAAANRISLTGDHSFQCEFCGEGFSTQTSFNRHRCGSTDIQIYRCENCRQEYGSSRAMSTIGNCEPRDKCDICNRNIVQSLPEEQAAYGPSMTAGSSPMSTQTTASVLSDGTIGGTVHLPTMIATLTSPEVSNESVSDLSANVNVRSIVNSPIEQHDLSSLDPFGSDSECLGQFFAAEPSSTSPCTASSTATNLQCQPMPTSANMGSLLSIPALHQPESAKTYFVLGNVDQLQQFHDIAAPPPATAEQAPVQQPPAGSNLPTPVTNSFHHLHLAPAGPGPHQQQQLLPLSLQNAAPATAGSLLLSEHEVTSLQQYDQYDDEDYSSMSEDEAIVPIEPYAKSPNQDHAKTELPIQETIVDTSTGISVMSLPPFGTGGLPRDADANGGGERRPHQTQSSTTTSTSTSTNPDRPYKCHICDRSYRNQKNLRSHLKVHEGIRAYQCEICGKNFSGSSYLVIHRRRHTGERPFKCVTCGKAFVDSRALAVHARLHSGERLKCEKCEKTFSSVSALTVHNRLHTGIHPYRCELCGKTFPQYNNLKHHMKKHEQPSDAEQLLPQAMATSTGGPTPPSNGVSTTTSGSGTVLARISLSIQADTTGKGTVHMIASSTTGPASEYKCHICNKLYKSSDDLQEHLSQHSKDRPNQCEFCSKVFPRSSHLIIHRRRHTGERPFKCKYCDKAFVDSRALSVHTRLHTGERVKCEICEKTFASSSGLIVHRRIHTGVHPYKCDYCEKSFAQSTALKYHLKKHDTALLPTTTTPEGADARLPALPQTGAADVGPCAPSFGEDATTNGNDRYKCTVCNKAFRSSEYLVRHRRTHSGERPYQCEICGKNFSTMSYLVIHRRRHTSERPYKCTSCEKAFVDSRALQEHARLHTGDRVRCEICQKTYSSVSNLIVHRRIHSGIHPFECDSCGKSFAQKNALKYHLKKHAETHKKQEQPEPVG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00105277;
90% Identity: iTF_00104527;
80% Identity: iTF_00104527;