Afon003115.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Anopheles fontenillei
Gene Symbol
zfh1
Assembly
GCA_008817895.1
Location
VTWG01024191.1:4048-6539[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 3.6e-06 0.0002 21.3 2.8 1 23 280 302 280 302 0.99
2 15 0.00044 0.025 14.7 4.9 1 23 314 336 314 336 0.96
3 15 1.5e-05 0.00083 19.4 0.8 2 23 346 367 345 367 0.95
4 15 3.6e-06 0.0002 21.3 3.8 1 23 373 395 373 395 0.99
5 15 0.019 1.1 9.6 0.1 2 23 403 424 402 424 0.97
6 15 9.4e-05 0.0053 16.9 3.4 1 23 430 453 430 453 0.94
7 15 0.0038 0.22 11.8 5.4 1 21 459 479 459 480 0.94
8 15 0.35 20 5.6 4.7 3 23 488 509 486 509 0.91
9 15 6.5e-05 0.0037 17.4 0.5 1 23 556 578 556 578 0.97
10 15 0.00013 0.0076 16.4 0.2 1 23 589 611 589 611 0.97
11 15 0.00087 0.049 13.8 3.3 1 23 636 658 636 658 0.98
12 15 0.35 20 5.6 2.4 2 23 694 715 693 715 0.94
13 15 0.00075 0.042 14.0 5.0 1 23 721 743 721 743 0.98
14 15 4.3e-07 2.4e-05 24.2 1.5 1 23 751 773 751 773 0.99
15 15 0.0005 0.028 14.6 0.7 1 23 779 802 779 802 0.96

Sequence Information

Coding Sequence
ATGGAATACAACAACACCTACAACAAACCGTACTGTGGCATATCGCAGCCGACcataccaccagcagcagctgcagtcCCAGGCAGCTCCGGGTTCTTCCCGGCCAATGATACCGCACCGTCACCGTTCCTTAAAGTGCCCAACCCACCGTACATCAAGCAGGAGACGGTCCCGGTGGGCGGAGAATCGGTTATCCCGGGTGGAACGGTAACACCGCCCGTCAACTACAGCcaggatcatcatcattatggAACGGCGGGGAGTTACGGCGAACCGGGCGATGTGGAGAAGCCACCCCTGTTCTATCGCAAAGCGTTCGACATGCCGTACATGGCGACACCGTACGTGCAGTCCCATCTTGCGCAACAATTTCCTCAACATCTTCCCTCACATCCTAACCAACTGCCGCCTCACCAGCACCATGCAGTACACAGTCAGCCGGTTCCTCATTtccaacaccagcaccagcagcagcagctcctccaccaccaccaccagccactTGCGCCACTACCTACGATCGTGCCATCCGATATGCATTCACCACAGCAACTTGGACCGGAACAGTTACAGCGAGCCCAgccgcagcaacaacaccaacagcaacagcatccgTCGAGCTTCCACGACTACTTTGACCACTTGGATCCTTCCTCCCTGGAACCGTATGCGTACGTGCTTCAAAAGCCTGCCCCACCGGCTCCACCGATCCAGCCCAGTGAAACTGGTTCCCCGCTGCCTGCCTCATACCCGACCGCCTCGCCAGttgctccaccagcagcaacaccttCCCCGTACACCCCGCTGTGTGAGCCGCCGGACAGCAGCAAGGTACGCTTCAAGTGTGAAACCTGTCCGAAATCGTTCGACACAAAGCAGAAGCTGGAAAAGCACAACCGCACCCATCAGCCGAACGGCGGGGGAGCGGCCGGGCTTGAGTTTAAATGCCGCATGTGCGACAAGACGTTCCGCACGAAGAGTACGCTCATCTGCCACGAGAAGGTGCACGGCGAGAGTGGCCTaggcagcagctgctcctgcGTCGAGTGCGGCAAGGTGTTTGCGACCGAGGAAAAGCTACAGGTGCACCGGCGGCTGCACACGGGCGAAAAACCGTACCAGTGCAAGGTGTGCCTGAAGTGCTTCAACCACCAATCGAACCTGATCGTGCACGCGCGCATCCACGACAAGGTGAAGCAGGCGCTCAAGTGTGCCCGGTGCAGCAAGGTGCTGGACAGCGAGGAGCGGCTCGCCGTCCATATGCGGCTGCACACGGGCGAAAAGCCGTACAAGTGTTCGTACTGCGACAAGCGCTTCAATCACAAGAGCACGGTCAGCACGCACGAGAAGGCGGCCCACATTGCGGCCAACTCGTACCGGTGTGGCCGCTGCCACAAGACGTTCAACCAGAAGTGCCAGCTGCAGTACCACGAGAAGCTGCAGGAGGAGCACACGATCGCGTGCGAGCACTGCGAGAAGGTGTTTTGCTACAAGGCGAGCCACAAGGAGCACCTGTTTAAGGTGCACTTCCCGCggccgaaaaagaaaacgcagcGGAAGGGAGGGAGTCTGCGGGAGGgagatgagcagcagcagcagcaggaaccgGGCACTGGCGGTGCAATGGCTGGAAGTAACGATGGTGGTAATCAGGGCCGCAACAAGTTCAAATGTACCGTGTGCGATCGTCGGTTTTACTACGAGCGGGCGCTCGAGATGCATATGGGCGTGCACGATGCATCGCTGGACGTGAACGTGCTGTACTTTTCCTGCGACTACTGTCCGGAAACGTTCACCGAGGAGGaaacgctgcagcagcacgaggCCCGCCACGTGGCCGACGGGACGACCGATTTCCGCGCAAACATGAAACGGGCCGAGGAAGGGGGAAACGACACCACCGGGCACAGGTGTCCGCTGTGCTTTAAGCAGTTTGAGGATGAACCATCCTTACGCGAACATCATCGATCGCACCTGTGCCCATTTCCCGACTGTGCGCGGTGCGACCCAGTACGGCGCGATGATGCGTTCGACCTGACGCGCAGTACGTACGATCCGGCGGACGATACGCAACCGACGGTGTGTAACGTGTGCCATCGCGTACTGCCAACGTTCGAGGCGTACCAGAACCACTTCCACTACCATACGTCGCGCGTCCCGTTCTACTGCTACCACTGCCGGGAGGAGTTTAACGACAAGCGGGAGCTGTACAACCACACGCGGACGCATGCGCCGCGCGCACCCGAATCGTACACGTGCGAGGTGTGCGCGAAGGTGTTCTCGACCAAGGGGAACTTTAAGCGGCATCTGAAATCTCACGAAGCGGTCCGGGCGTTCGCGTGCGATCGCTGCTCGAAGCAGTACGACTACAAGAGTGCGCTCGAGGTGCATCTGAAGCGTTCGCACGGTATTGAGCTGTGA
Protein Sequence
MEYNNTYNKPYCGISQPTIPPAAAAVPGSSGFFPANDTAPSPFLKVPNPPYIKQETVPVGGESVIPGGTVTPPVNYSQDHHHYGTAGSYGEPGDVEKPPLFYRKAFDMPYMATPYVQSHLAQQFPQHLPSHPNQLPPHQHHAVHSQPVPHFQHQHQQQQLLHHHHQPLAPLPTIVPSDMHSPQQLGPEQLQRAQPQQQHQQQQHPSSFHDYFDHLDPSSLEPYAYVLQKPAPPAPPIQPSETGSPLPASYPTASPVAPPAATPSPYTPLCEPPDSSKVRFKCETCPKSFDTKQKLEKHNRTHQPNGGGAAGLEFKCRMCDKTFRTKSTLICHEKVHGESGLGSSCSCVECGKVFATEEKLQVHRRLHTGEKPYQCKVCLKCFNHQSNLIVHARIHDKVKQALKCARCSKVLDSEERLAVHMRLHTGEKPYKCSYCDKRFNHKSTVSTHEKAAHIAANSYRCGRCHKTFNQKCQLQYHEKLQEEHTIACEHCEKVFCYKASHKEHLFKVHFPRPKKKTQRKGGSLREGDEQQQQQEPGTGGAMAGSNDGGNQGRNKFKCTVCDRRFYYERALEMHMGVHDASLDVNVLYFSCDYCPETFTEEETLQQHEARHVADGTTDFRANMKRAEEGGNDTTGHRCPLCFKQFEDEPSLREHHRSHLCPFPDCARCDPVRRDDAFDLTRSTYDPADDTQPTVCNVCHRVLPTFEAYQNHFHYHTSRVPFYCYHCREEFNDKRELYNHTRTHAPRAPESYTCEVCAKVFSTKGNFKRHLKSHEAVRAFACDRCSKQYDYKSALEVHLKRSHGIEL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00095782; iTF_00093613; iTF_00102510;
90% Identity
iTF_00093613;
80% Identity
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