Basic Information

Insect: Anopheles gambiae
Gene Symbol: zfh1
Assembly: GCF_000005575.2
Location: NT:20581730-20589281[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 4.2e-06 0.00022 21.0 2.0 1 23 174 196 174 196 0.98

2 15 0.00034 0.018 15.0 4.9 1 23 208 230 208 230 0.96

3 15 1.1e-05 0.00058 19.7 0.8 2 23 240 261 239 261 0.95

4 15 2.8e-06 0.00014 21.6 3.8 1 23 267 289 267 289 0.99

5 15 0.015 0.76 9.9 0.1 2 23 297 318 296 318 0.97

6 15 7.2e-05 0.0037 17.2 3.4 1 23 324 347 324 347 0.94

7 15 0.003 0.15 12.1 5.4 1 21 353 373 353 374 0.94

8 15 0.27 14 5.9 4.7 3 23 382 403 380 403 0.91

9 15 5e-05 0.0026 17.6 0.5 1 23 425 447 425 447 0.97

10 15 0.0001 0.0053 16.7 0.2 1 23 458 480 458 480 0.97

11 15 0.00068 0.034 14.1 3.3 1 23 505 527 505 527 0.98

12 15 0.27 14 5.9 2.4 2 23 563 584 562 584 0.94

13 15 0.00058 0.03 14.3 5.0 1 23 590 612 590 612 0.98

14 15 3.3e-07 1.7e-05 24.5 1.5 1 23 620 642 620 642 0.99

15 15 0.00039 0.02 14.9 0.7 1 23 648 671 648 671 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	4.2e-06	0.00022	21.0	2.0	1	23	174	196	174	196	0.98
2	15	0.00034	0.018	15.0	4.9	1	23	208	230	208	230	0.96
3	15	1.1e-05	0.00058	19.7	0.8	2	23	240	261	239	261	0.95
4	15	2.8e-06	0.00014	21.6	3.8	1	23	267	289	267	289	0.99
5	15	0.015	0.76	9.9	0.1	2	23	297	318	296	318	0.97
6	15	7.2e-05	0.0037	17.2	3.4	1	23	324	347	324	347	0.94
7	15	0.003	0.15	12.1	5.4	1	21	353	373	353	374	0.94
8	15	0.27	14	5.9	4.7	3	23	382	403	380	403	0.91
9	15	5e-05	0.0026	17.6	0.5	1	23	425	447	425	447	0.97
10	15	0.0001	0.0053	16.7	0.2	1	23	458	480	458	480	0.97
11	15	0.00068	0.034	14.1	3.3	1	23	505	527	505	527	0.98
12	15	0.27	14	5.9	2.4	2	23	563	584	562	584	0.94
13	15	0.00058	0.03	14.3	5.0	1	23	590	612	590	612	0.98
14	15	3.3e-07	1.7e-05	24.5	1.5	1	23	620	642	620	642	0.99
15	15	0.00039	0.02	14.9	0.7	1	23	648	671	648	671	0.96

Sequence Information

Coding Sequence: GATTATCCCTCATCCCCCAAGATTTATCCCGTCCCAAAACCACccgtCCCAGGCAGCTCCGGCTTCTTTCCGGCCAATGATACCGCACCGTCACCGTTCCTTAAAGTGCCCAACCCACCGTACATCAAGCAGGAGACGGTCCCGGTGGGCGGAGAATCGGTTATCCCGGGTGGAACGGTAACACCGCCCGTCAACTACAGCcaggatcatcatcattatggAACGGCGGGGAGTTACGGCGAACCGGGCGATGTGGAGAAGCCACCCCTGTTCTATCGCAAAGCGTTTGACATGCCGTACATGGCGACACCGTACGTGCAGTCCCATCTTGCCCAACAGTTTCCTCAACATCTTCCCTCACATCCTAACCAACTGCCGCCTCACCAGCACCATGCACCCAGTGAAACTGGTTCCCCGCTGCCTGCCTCATACCCGACCGCCTCGCCAGTtgctccaccagcagcaacaccttCCCCGTACACCCCGCTGTGTGAGCCGCCGGACAGCAGCAAGGTACGCTTCAAGTGTGAAACCTGTCCGAAATCGTTCGACACGAAGCAGAAGCTGGAAAAACACAACCGCATCCATCAGCCGAACGGCGGGGGTGCGGCCGGGCTCGAGTTTAAATGCCGCATGTGCGACAAAACGTTCCGTACGAAGAGTACGCTCATCTGCCACGAGAAGGTGCACGGCGAGAGTGGCCTAGGCAGCAGCTGCTCCTGCGTCGAGTGCGGCAAGGTGTTTGCGACGGAGGAAAAGCTACAGGTGCACCGGCGGCTGCACACGGGCGAAAAACCGTACCAGTGCAAGGTGTGCCTGAAGTGCTTCAACCACCAATCGAACCTGATCGTGCACGCGCGCATCCATGACAAGGTGAAGCAGGCGCTCAAGTGTGCCCGGTGCAGCAAGGTGCTGGACAGCGAGGAGCGGCTCGCCGTCCATATGCGGCTGCACACGGGCGAAAAGCCGTACAAGTGTTCGTACTGCGACAAGCGCTTTAATCACAAGAGCACGGTCAGCACGCACGAGAAGGCGGCCCACATTGCGGCCAACTCGTACCGGTGTGGCCGCTGCCACAAGACGTTCAACCAGAAGTGCCAGCTGCAGTACCACGAGAAGCTGCAGGAGGAGCACACGATCGCGTGCGAGCACTGCGAGAAGGTGTTCTGCTACAAGGCGAGCCACAAGGAGCACCTGTTTAAGGTGCACTTCCCGCGGCCGAAAAAGAAAGCGCAGCGGAAGGGAGGGAGGGGTAATCAGGGCCGGAACAAGTTCAAATGTACAGTGTGCGATCGTCGGTTTTACTACGAGCGGGCGCTCGAGATGCATATGGGCGTGCACGATGCATCGCTGGACGTGAACGTGCTGTACTTTTCCTGCGACTACTGTCCGGAAACGTTCACCGAGGAGGagacgctgcagcagcacgagGCCCGCCACGTGGCCGACGGGACGACCGATTTCCGCGCAAACATGAAACGGGCCGAGGAAGGGGGAAACGCCACCACCGGGCACAGGTGTCCGCTGTGCTTTAAGCAGTTTGAGGATGAGCCGTCCTTACGCGAACATCACCGTTCGCACCTGTGCCCATTTCCCGACTGTGCGCGGTGCGACCCAGTACGGCGCGATGATGCGTTCGATCTGACGCGCAGTACGTACGATCCGGCGGACGATACGCAACCGACGGTGTGTAACGTGTGCCATCGCGTACTGCCAACGTTCGAGGCGTACCAGAACCACTTCCACTACCATACGTCGCGCGTCCCGTTCTACTGCTACCACTGCCGGGAGGAGTTTAACGACAAGCGGGAGCTGTACAATCACACGCGGACGCATGCGCCGCGCGCACCGGAATCGTACACGTGCGAGGTGTGCGCGAAGGTGTTCTCGACTAAGGGGAACTTTAAGCGGCATTTGAAATCTCACGAAGCGGTCCGGGCGTTCGCGTGCGATCGCTGCTCGAAGCAGTACGACTACAAGAGTGCGCTCGAGGTGCATCTGAAGCGTTCGCACGGTATTGAGCTGTGA
Protein Sequence: DYPSSPKIYPVPKPPVPGSSGFFPANDTAPSPFLKVPNPPYIKQETVPVGGESVIPGGTVTPPVNYSQDHHHYGTAGSYGEPGDVEKPPLFYRKAFDMPYMATPYVQSHLAQQFPQHLPSHPNQLPPHQHHAPSETGSPLPASYPTASPVAPPAATPSPYTPLCEPPDSSKVRFKCETCPKSFDTKQKLEKHNRIHQPNGGGAAGLEFKCRMCDKTFRTKSTLICHEKVHGESGLGSSCSCVECGKVFATEEKLQVHRRLHTGEKPYQCKVCLKCFNHQSNLIVHARIHDKVKQALKCARCSKVLDSEERLAVHMRLHTGEKPYKCSYCDKRFNHKSTVSTHEKAAHIAANSYRCGRCHKTFNQKCQLQYHEKLQEEHTIACEHCEKVFCYKASHKEHLFKVHFPRPKKKAQRKGGRGNQGRNKFKCTVCDRRFYYERALEMHMGVHDASLDVNVLYFSCDYCPETFTEEETLQQHEARHVADGTTDFRANMKRAEEGGNATTGHRCPLCFKQFEDEPSLREHHRSHLCPFPDCARCDPVRRDDAFDLTRSTYDPADDTQPTVCNVCHRVLPTFEAYQNHFHYHTSRVPFYCYHCREEFNDKRELYNHTRTHAPRAPESYTCEVCAKVFSTKGNFKRHLKSHEAVRAFACDRCSKQYDYKSALEVHLKRSHGIEL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00101103;
90% Identity: -
80% Identity: -