Acou009711.1
Basic Information
- Insect
- Anopheles coustani
- Gene Symbol
- MBD2
- Assembly
- GCA_943734705.2
- Location
- OX030901.1:20588223-20589841[+]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 9e-25 2.5e-21 75.2 0.0 1 72 5 71 5 76 0.93 2 2 0.00051 1.4 8.7 0.0 29 75 144 201 124 202 0.89
Sequence Information
- Coding Sequence
- ATGAATGTATCCATCGAACGGAAGCGTAATGATTGTGTGGCACTACCCAAGGGATGGCAAAGGGAAGAGGTGCTCCGCAAGACGGGCCTATCGGCCGGAAAGGTCGATGTGTACTATTACAGTCCTACcgggaagaaaatcgaaagcaaACCACAGCTCGCCCGTGCCCTCGGTGATACTATCGATCTGTCCACGTTCGACTATCACGCGGGCCGCATAATAGCGCCACCATCCGTGGCCGCAGCACAACTTCTGCACGCCCATCATAGCCCTAGCTTTCAGTTGCAGCAAAGCTGTGCGCTTCGCCGGAAGCTGCCACCAGGAGCGGTCGTGGGTGTTCCGCTTGGTGGAAGCAATGCTCTCACTGCAACCCCTATTAGCTCCGGATGTAGCGTAAAACCTTCGCATCAGTACGATTACAGTCGCGGAATGCGAGCAGACACCTCACTCATCCCACCGATCAGGCAAACGGCATCGATCTTCAAACAGCCAGTGACGGTTGTACGATCACAGGAGCCCGAAAACAGCAAAGTAAAGCGAGAGCTCCAGCATGGAAGTCAGGTTAAACCAAAGCAATTGTTCTGGGAAAAACGACTAGAGAAATCCGGAGCAAGTAATACTCACAACGAGGAGATCGGCACTATCGAGCTGCCAAAGCGGCTACGACCGATCGGTCCGGGCATTCGAGAAACAACGCTACTGCAATCGTTAGCCACTGCCCTGCATCACAACACACACCCCGTGACCGGCCAGACAGCCTCGAAGACGTCGCTCAACACGAATGTTGGGGTGTTTATCAATCCGGACCAACCTCTGATGACCAATGTAACGATCACAGAAGAGGACATCAAACGACAAGAGGAACGTGTCCAGAACGCTCGATTACAGCTACAGGAAGCGTTGCGTGCGTAG
- Protein Sequence
- MNVSIERKRNDCVALPKGWQREEVLRKTGLSAGKVDVYYYSPTGKKIESKPQLARALGDTIDLSTFDYHAGRIIAPPSVAAAQLLHAHHSPSFQLQQSCALRRKLPPGAVVGVPLGGSNALTATPISSGCSVKPSHQYDYSRGMRADTSLIPPIRQTASIFKQPVTVVRSQEPENSKVKRELQHGSQVKPKQLFWEKRLEKSGASNTHNEEIGTIELPKRLRPIGPGIRETTLLQSLATALHHNTHPVTGQTASKTSLNTNVGVFINPDQPLMTNVTITEEDIKRQEERVQNARLQLQEALRA
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00098998;
- 90% Identity
- iTF_00109142; iTF_00107685; iTF_00105827; iTF_00094011;
- 80% Identity
- iTF_00109142;