Basic Information

Gene Symbol
MBD2
Assembly
GCA_034621735.1
Location
JAOEFI010000003.1:38303189-38304807[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 4.7e-25 1.5e-21 75.9 0.0 1 72 5 71 5 76 0.93
2 2 0.00042 1.3 8.7 0.0 29 75 147 204 128 205 0.88

Sequence Information

Coding Sequence
ATGAATGTGtccatcgaacggaagcgTACCGACTGTGTCGCACTGCCCAAGGGATGGCAAAGGGAAGAACTTCTCCGCAAGACGGGCCTTTCAGCTGGCAAAGTCGATGTCTACTACTACAGTCctacggggaagaaaatcgaaagtaaACCTCAGCTTGCTCGCGTCCTCGGCGATACGATCGATCTGTCCACATTCGATTACCACGCGGGCCGTATCATTGCGCCGCCCTCTGTGGCCGCGGCTCAACTTCTGCACGCGCATCACGGTACTAGTTATCAGTTGCAACAAAACTCTGCCCTCCGCCGGAAGCTGCCCCCAGGATCTCCTATAGGAAGCGGCGGCGTTCCACTCGGTGGAAGTCCCTCTCTAACTGCCACACCGATCAGCTCTGGATACAGTGTGAAACCTTCGCACCAGTTCGATTACAgTCGTGGAATGCGTGCTGATACATCACTAATCCCACCAATCAGACAAACGGCATCAATCTTTAAACAACCCGTTACGGTGGTACGGTCACAGGAACCAGAGAATAACAAGTTGAAGCGCGAACTTCAGCACGGCAGTCAAGTGAAACCGAAGCAGCTTTTTTGGGAGAAACGTTTAGAGAAATTGGGAGCAAGCAATACGCACAACGAAGAGATCGGCTCGATTGAGCTGCCGAAGCGGCTGCGGCCGATCGGACCAGGAATTCGCGAAACGACGGTTCTGCAATCGTTGGCCACCGCCTTACATCACAACACCCATCCCGTGACTGGGCAGACAGCGTCCAAGACATCGCTCAACACGAACGTTGGGGTGTTTATCAATCCGGATCAACCCATGATGACCAATGCAACCATCTCGGAGGAAGACATCAAGCGACAGGAAGAACGCGTTCAGTACGCCCGATTACAGCTACAAGATGCGTTGCGTGCATAG
Protein Sequence
MNVSIERKRTDCVALPKGWQREELLRKTGLSAGKVDVYYYSPTGKKIESKPQLARVLGDTIDLSTFDYHAGRIIAPPSVAAAQLLHAHHGTSYQLQQNSALRRKLPPGSPIGSGGVPLGGSPSLTATPISSGYSVKPSHQFDYSRGMRADTSLIPPIRQTASIFKQPVTVVRSQEPENNKLKRELQHGSQVKPKQLFWEKRLEKLGASNTHNEEIGSIELPKRLRPIGPGIRETTVLQSLATALHHNTHPVTGQTASKTSLNTNVGVFINPDQPMMTNATISEEDIKRQEERVQYARLQLQDALRA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00094011;
90% Identity
iTF_00096383;
80% Identity
-