Asin005423.1
Basic Information
- Insect
- Anopheles sinensis
- Gene Symbol
- MBD2
- Assembly
- GCA_000441895.2
- Location
- KE525303.1:177119-179135[+]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 5.2e-25 2e-21 75.2 0.0 1 72 5 71 5 76 0.93 2 2 0.0003 1.2 8.6 0.0 29 75 147 204 130 205 0.88
Sequence Information
- Coding Sequence
- ATGAATGTATCCATCGAACGAAAGCGTAACGATTGTGTCGCACTGCCCAAGGGATGGCAAAGGGAAGAGGTTCTCCGCAAGACGGGCCTTTCGGCCGGGAAGGTCGATGTGTACTACTACAGTCCTACCGGGAAGAAAATCGAAAGCAAACCACAGCTCGCCCGTGCCCTCGGTGATACTATCGATCTGTCCACGTTCGACTATCACGCGGGCCGCATTATAGCACCACCATCGGTGGCCGCCGCACAACTTCTGCACGCACATCATAGCCCTAGCTTTCAGTTGCAGCAAAGCTGTGCACTTCGCCGGAAGCTACCACCGGGAGCGATCGTGGGGTGTGTTGGTGGTCCGCTTGGTGGAAGCAATGCTCTCACTGCAACCCCGATTAGCTCCGGATGTAGTGTAAAACCTTCGCATCAGTACGATTACAGTCGCGGAATGCGAGCAGACACCTCGCTCATCCCACCGATCAGGCAAACGGCATCGATCTTCAAACAGCCAGTGACGGTTGTACGATCACAGGAGCCCGAAAACAGCAAAGTAAAGCGAGAGCTCCAGCATGGAAGTCAGGTTAAACCAAAGCAACTGTTCTGGGAGAAACGTCTAGAGAAATCAGGAGCAAGTGATACGCACAACGAGGAGATCGGAACGATCGAGCTGCCAAAGCGACTACGACCGGTCGGACCGGGCATCCGAGAAACTACGCTACTGCAATCGTTAGCTACTGCCCTGCACCACAACACCCACCCCGTGACCGGCCAAACTGCCTCGAAGACGTCGCTCAATACGAACGTTGGGGTGTTTATCAATCCGGACCAACCGCTGATGACCAATGTGACAATCACAGAGGAGGACATCAAGCGACAGGAGGAACGTGTCCAGCACGCTCGATTACAGCTACAGGAAGCGTTGCGTGCGTAG
- Protein Sequence
- MNVSIERKRNDCVALPKGWQREEVLRKTGLSAGKVDVYYYSPTGKKIESKPQLARALGDTIDLSTFDYHAGRIIAPPSVAAAQLLHAHHSPSFQLQQSCALRRKLPPGAIVGCVGGPLGGSNALTATPISSGCSVKPSHQYDYSRGMRADTSLIPPIRQTASIFKQPVTVVRSQEPENSKVKRELQHGSQVKPKQLFWEKRLEKSGASDTHNEEIGTIELPKRLRPVGPGIRETTLLQSLATALHHNTHPVTGQTASKTSLNTNVGVFINPDQPLMTNVTITEEDIKRQEERVQHARLQLQEALRA
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00094011;
- 90% Identity
- iTF_00096383;
- 80% Identity
- -