Basic Information

Gene Symbol
MBD2
Assembly
GCA_027943255.1
Location
JAPTHQ010000158.1:682016-685042[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 4.2e-28 5e-24 85.1 0.0 1 73 7 74 7 78 0.95
2 2 0.0017 20 6.2 0.0 29 58 217 246 201 275 0.80

Sequence Information

Coding Sequence
ATGAACTCCAGTATAACAATTGAGCGTAAGCGTGTTGATTGCAATTCGTTACCAAAGGGCTGGCAGCGGGAGGAAGTGCTACGTAAGTCTGGTATATCAGCTGGTAAAGTCGATGTGTATTATTACAGTCCAACCGGCAAGAAAATCGAAAGTAAGCCACAATTGGCGCGTTACCTGGGCGATGCAATCGACATTGGTGCATTCGATTTTCATAACGGCAAATTCGTGCGTCACTTGCCACCGCCGTCAATTTCACTATTCCGTTGCAGTAGCTTAACTAACAGCGGCAACGGAGCTAGTGGCAGTGGCAATACATCCATGCCGCCACCACCACCACAGTGTAGTGCCGGAAGTACTTTATCCTTAACTGTATGTTCCTCCCCAAATTCTTCACAATTACCTAATACTACAAATGCCAACATACTACAACCACCAACGCCAACAACATCAAATACGCCAAATTCATTAAAGCGCAAATACAAGGCGCATTCCTTATCCCAACCACAAATTCAGAATCAATCACAGACCCACCAGTTACAAGGCATGCATACGAATGCCACTAGTAGCAGTTGCGCCCCATCAAGCGCATGTGGTGCTGCAACTACATCGACAGCGAGTTCACGGCAGCAATTAGAATTCAGTCGCACACCACGCACAGACGCTTCTTTAGTACCACCTATACGTCAAACTGCATCGATTTTCAAACAACCAGTCACTGTGGTGCGCAACCATGAGTTTACAAAGGTGCGAAACGATAACTCCAAACAGGTAAATGGGCAGGAGAAACCAAAGCAAATGTTCTGGGAGAAACGATTAGAGGGTTTGCGCGCCTGCCACCCCACCGGTGAGGAGTTTGATGATATCGTACTACCGAAGAGTATACGCACGATTGGACCGAATGTTAATGAACAAACTGTGCTGCAATCGTTGGCCACCGCTCTGCATGTGCTTAACGTCCCCGTGATGGGTCAAGCCTCCACAAAGACTGAGATGAATAAGAATGCCACGGCATTTTTGAATCCGGAACAACCGCTGATGCAAGCCGTTCTTGTTTCGGATGACGATATACGGCGTCAGGAAGATCGAGTTAATGTGGCTCGAAAAAAGCTGCAGGACGCTCTTAAAGCTTAG
Protein Sequence
MNSSITIERKRVDCNSLPKGWQREEVLRKSGISAGKVDVYYYSPTGKKIESKPQLARYLGDAIDIGAFDFHNGKFVRHLPPPSISLFRCSSLTNSGNGASGSGNTSMPPPPPQCSAGSTLSLTVCSSPNSSQLPNTTNANILQPPTPTTSNTPNSLKRKYKAHSLSQPQIQNQSQTHQLQGMHTNATSSSCAPSSACGAATTSTASSRQQLEFSRTPRTDASLVPPIRQTASIFKQPVTVVRNHEFTKVRNDNSKQVNGQEKPKQMFWEKRLEGLRACHPTGEEFDDIVLPKSIRTIGPNVNEQTVLQSLATALHVLNVPVMGQASTKTEMNKNATAFLNPEQPLMQAVLVSDDDIRRQEDRVNVARKKLQDALKA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01045464;
90% Identity
iTF_00081224;
80% Identity
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