Basic Information

Gene Symbol
MBD2
Assembly
GCA_037575425.1
Location
JAYXIM010056090.1:49750-52767[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 5.3e-28 4.7e-24 85.1 0.0 1 73 7 74 7 78 0.95
2 2 0.0018 16 6.5 0.0 29 62 217 249 201 274 0.79

Sequence Information

Coding Sequence
ATGAACTCCAGTATAACAATTGaacgtaagcgtgttgattgCAATTCGTTACCAAAGGGCTGGCAGCGGGAGGAAGTGCTACGTAAGTCTGGTATATCAGCTGGTAAAGTCGATGTGTATTATTACAGTCCAACCGGCAAGAAAATCGAAAGTAAGCCACAATTGGCGCGTTACCTGGGCGATGCAATCGACATTGGTGCATTCGATTTTCATAACGGCAAATTCGTGCGTCACTTGCCACCGCCGTCAATTTCACTATTCCGTTGCAGTAGCTTAACTAACAGCGGCAACGGTGCTAGTGGCAGTGGCAATACATCAatgccgccaccaccaccacagtGTAGTGCCGGAAGTACTTTATCCTTAACTGTATGTTCCTCCCCAAATTCTTCACAATTACCTAATACTACAAATGCCAACATACTACAACCACCAACGCCAACAACATCAAATACGCCAAATTCATTAAAGCGCAAATACAAGGCGCATTCCTTATCCCAACCACAAATTCAGAATCAATCACAGACCCACCAGTTACAAGGCATGCATACGAATGCCACTAGTAGCAGTTGCGCCCCATCAAGCGCATGTGGTGCTGCAACTACATCGACAGCGAGTTCACGGCAGCAATTAGAATTCAGTCGCACACCACGCACAGACGCTTCTTTAGTACCACCTATACGTCAAACTGCATCGATTTTCAAACAACCAGTCACTGTGGTGCGAAATCATGAGTTTACAAAGGTGCGAAACGATAACTCCAAACTGGTAAATGGGCAGGAGAAACCAAAGCAAATGTTCTGGGAGAAACGATTAGAGGGTTTGCGTGCCTGTCACCCCACCGGTGAGGAGTTTGATGATATCGTACTACCGAAGAGTATACGCACGATTGGACCGAATGTTAATGAACAAACTGTGCTGCAATCGTTGGCCACCGCTCTGCATGTGCTTAACGTCCCCGTGATGGGTCAAGCCTCCACAAAGACTGAGATGAATAAGAATGCCACGGCATTTTTGAATCCGGAACAACCGCTGATGCAAGCCGTTCTTGTTTCGGATGACGATATACGGCGTCAGGAAGATCGAGTTAATGTGGCTCGAAAAAAGCTGCAGGACGCTCTTAAAGCTTAG
Protein Sequence
MNSSITIERKRVDCNSLPKGWQREEVLRKSGISAGKVDVYYYSPTGKKIESKPQLARYLGDAIDIGAFDFHNGKFVRHLPPPSISLFRCSSLTNSGNGASGSGNTSMPPPPPQCSAGSTLSLTVCSSPNSSQLPNTTNANILQPPTPTTSNTPNSLKRKYKAHSLSQPQIQNQSQTHQLQGMHTNATSSSCAPSSACGAATTSTASSRQQLEFSRTPRTDASLVPPIRQTASIFKQPVTVVRNHEFTKVRNDNSKLVNGQEKPKQMFWEKRLEGLRACHPTGEEFDDIVLPKSIRTIGPNVNEQTVLQSLATALHVLNVPVMGQASTKTEMNKNATAFLNPEQPLMQAVLVSDDDIRRQEDRVNVARKKLQDALKA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01045464;
90% Identity
iTF_00082129; iTF_00082941;
80% Identity
iTF_00082129;