Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_963565655.1
Location
OY751424.1:4060093-4065867[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 3.6e-19 1e-15 57.2 0.3 8 69 488 549 482 556 0.93
2 2 1.7 4.8e+03 -2.6 0.0 41 58 1083 1100 1083 1109 0.84

Sequence Information

Coding Sequence
ATGGCGCGTAAATGCTgcgtgaaaaattgtaataccAATGCTAAAGCAGTTAATAAATATGGATTGAGACTGCACAAATTTCCCAAggattcattgataaaagcCAAGTGGTTTGATAATTGTCGGATTGATACCGATTGCCGGGCAACACCTGGCCCATTTATATGTTACAAACACTTTAAAAGAAGTGATTATGATATTATTAAGGGACACAAGTATTTGCTCAAGGAAAATGCTGTGCCGAGTGTTTTCGAGGACTACGACGATCATCCTGATCCTATAATAATGCCAGTGAAGACACGAAACGTCTCGTATCCTCAAGAAGATCTtgatctcattaattcaaagacAAATAATGTTGATGAAAGAACCGATGGGATTGATTCCCCTGGTTACAACGACAGCTGCGGGGAAGCTTGTAATTCGAGACCACAATCTTCTGCTGATTCTCTGAATCCATCGGAGAGCCAGGATGATAACGAGGCAACTGGGAAGTTATTAGATATTGAATGTGAGATGGAGAAAGTTAAGAAGAgtgaattcaaagaatcaCCACCGGCTGAACCACCTCCAATTGATTCAtctctcaataaaattaagaatatcaataaaatggagaatattgTTAAGAAGGATAAGAAAGTGTCTAGGGgagatttaaaattttttcctGGTGCCAAATTAGAGGCTAAAGACTTCAATGATCAGTGGTATGCGGCAAGAGTCGTTGAGACTGACTGGGTAGAAAGGGAAGTATTGATACATTTCGACAAGTGGAATTCAAGATTTGATGAGTGGATACCAATGGATAGCTCAAGGCTCAGGGTACTGCAGATGCAGCCTAGtgaacaaGATTGGGTCATTGCAACTCCGGAGACAAAACCCCGAGATTTTTCAGTTGGCGAGAGAATATTAGCGACGTGGGCAGATGGCAGAAAGTATCCAGCCAAAGTAAAGGCACTCATGGGAAATgatCGTTACGACGTATTATTTGACGATGGTTATTCGAAGGTTTTACGCTCCTCAAAGATGACTAAAATTGCTGGAACATTGGACAAGTCAAGTGCACAGCAACAATCAGCGATGGAGGCTGAATCTTACATTGGTAGCAAGCAAGAGAGAAGAGACAAGAAAAGGAAGCATACAGTGACGGAATTATTTAACAGCAGGAAACGTACAAAAACAGAGAGTGAAAGATCATCGAAGAAAGAAGATAATCAAGATGAGAATGAAACGGAAATTCATGAAGCTAATGGCAGTGGAAGTTATGATTCTGGTGCAGAGATGCTGAAGGGTTTTCCAaatcagaagaaaattaagaatttcacgaaaaggaagagagagtaTCAGAAGGTTGATACTGATCAGGAAGATGACGTTGGTCCTGAGTGGGTTGATGGAGAACCACAGGGAATCGAGTCATTCACAACTGATGGCTCGAGAAGATCAATAATTGTGCCTGATAGAAGATTACCACCTGGATGGCAGAAGCATTTTGTCCAGAGGAAAACAGGAAGTTCTGCTGGGAAGTGGGACGTTCTTTTTGTCCAcaaattgagtggaaaaaagttcAGATCGAGGAATGACTTGAAGACGTACTTCGAGAGCCAGGGACAAACGAATTTCAATCCTGAGATGTTTGACTTCTGCATACATCGTAAGAAGAAGGCAGGAGGTGCAAAGAATCAGACACCAAAGCCGGAGAGTCCTGTTGAGACTCCGAAGAAGATTAAGACACTTTTACCGAAGACTAAAGCAAATCCTGGTACTGCTGATAATCTTCTGTTAACGCCTGTAACATCGGCACTTGCACAGACACCTACGCCTTTGCCAGCGGCTGCACCTATTGATGACAGTGCGGTGTTTATCGGAGGCCTGCGAGTGGAAATGGAGGACAGTGCCTACAAGTGTCCCATCGAAGGCTGCACCAAGACCTTCCGCAAGGAGAATCTCCTCCAGATGCATATTAAACATTATCACAAAGAATACTCGCAATTCGTTGGATCAACACCAAACGTCGCTGATCTAGCATACGCAAGAACAATTGGCGAATCAATTCAAGATGTTACCccgaaaaaaacgaatgaaaaacgTAAATCACTTCATGAGAGACCACTTCATTCACTCACAATGTCACCCTTAACTACTTCGattctcgataattcattGACAGATAATGGGAttgttgatggaaaattggagatgATGTCACCAACGTCAAACAGTAGCATGGACGTCACTGATGATGGTGCACATAAGAGTGAGTGTGCTATGTCACCAGGTTCACTCTTTGatatgaaaataagagaggaaaaaacgcAGACTGGAATTAAAACACTGCTGCCAGTCAGACCGAGTAATAGCACTGATTCGCAGAGGATTGATAGGTCTAAATCATTGGATGATGGTGGTAATTTCGAGAAGATCAAGGGACAGAGAAAGAGGCAATTGTCGGAGTACAGTTCGGATGCATCGACAAAGAGCAGAAAACCGAAAGGCATGCAGGAGCTTACTGATGAATATGGAGACTTGGATGACAGTGCACTTGATGCTGAGGGGCCAGCTGGACTCGTTTACAGATACAGTCGTAGGAAATCAGATGCTAAGAGCGACGATAATAGTCAGAGCAATGGTGATGgtgtgatgatgatgataaacgGGGAGCTGGTGAAAGTGGAGCAGTTGAAACGAGAAGAGATAATCAATTGTACCTGCGGAATAACAGAGGAGGATGGGCTCATGATCCAGTGTGACCTCTGCCTCTGCTGGCAGCATGGACACTGTAATGCGATTGAACGTGAGCGAGACGTTCCTGACAAGTACATCTGCTACATCTGCCGCAATCCTTTCCGAGGAAGACAGTCAAAGAAATACTCGCACAATCAGGATTggataaaagaaggaaaactGGAGAGTCTGTCGAAGAGAACGAAGAATCAAGAGGCCATTAATCACAGAACTGCTGTTCTGAAGCGCTCGTATGATCTAGTTGGTGCATTAATAGAGATTCAGCGGATTCTTCATAGTCTGAGGGTCAAAATCAATGTTGTACAGAAGAAAGATCATCCCAAGCTCTATTTATGGgcgaaaaattgggaaaagaGTGAAATACCAGAGCCTCAGCTGGAGCCAGTgccaattattgaaataataacacCGAAAACGGTTGTCGACGAGGCGGCAGCTGAATTGCcagtgaaaaatgaggagagtgatgataaaaatgaaattaaacgtGAAGATGATAAACAAATTTCTTCGGAttcggaattaatgaaaatacttgaGGAAGATAATTCTGTGATAAATGAGGCGAAGGttaattgtaaaaaagaggaggatgaGGGGAAGAATGATGGGAGGATACTGCTCGATGCTCTGACTAGGAGCGAAGATGATAAGAAAGGGGAGGAGGTTAAGAGAGAGGGCGATGGAGCGGATGGGGAACCAGGTGTGCCTTTGGAGGAGACGATTAAGAAGCTACAGCCGTTTGTACCGGAGCCGGAAGCACCGATCGATCCTGATGAGTGTCGGCTCAGGCTCTTGGAGCATATTGAACACTTTCAGGATCACATTGATGCACAATTGGCGACGATTGAAGCACAAGTTGATGCACTTGAGACAATGGAGCCAACTGATGATAGATCATCTGATGTACAGCCACGTATGAAGCAGACCATACAAATGCTAATGAGGGATCTTGCTACAGTACGAAAATTGGCTGCTCTATGTTGA
Protein Sequence
MARKCCVKNCNTNAKAVNKYGLRLHKFPKDSLIKAKWFDNCRIDTDCRATPGPFICYKHFKRSDYDIIKGHKYLLKENAVPSVFEDYDDHPDPIIMPVKTRNVSYPQEDLDLINSKTNNVDERTDGIDSPGYNDSCGEACNSRPQSSADSLNPSESQDDNEATGKLLDIECEMEKVKKSEFKESPPAEPPPIDSSLNKIKNINKMENIVKKDKKVSRGDLKFFPGAKLEAKDFNDQWYAARVVETDWVEREVLIHFDKWNSRFDEWIPMDSSRLRVLQMQPSEQDWVIATPETKPRDFSVGERILATWADGRKYPAKVKALMGNDRYDVLFDDGYSKVLRSSKMTKIAGTLDKSSAQQQSAMEAESYIGSKQERRDKKRKHTVTELFNSRKRTKTESERSSKKEDNQDENETEIHEANGSGSYDSGAEMLKGFPNQKKIKNFTKRKREYQKVDTDQEDDVGPEWVDGEPQGIESFTTDGSRRSIIVPDRRLPPGWQKHFVQRKTGSSAGKWDVLFVHKLSGKKFRSRNDLKTYFESQGQTNFNPEMFDFCIHRKKKAGGAKNQTPKPESPVETPKKIKTLLPKTKANPGTADNLLLTPVTSALAQTPTPLPAAAPIDDSAVFIGGLRVEMEDSAYKCPIEGCTKTFRKENLLQMHIKHYHKEYSQFVGSTPNVADLAYARTIGESIQDVTPKKTNEKRKSLHERPLHSLTMSPLTTSILDNSLTDNGIVDGKLEMMSPTSNSSMDVTDDGAHKSECAMSPGSLFDMKIREEKTQTGIKTLLPVRPSNSTDSQRIDRSKSLDDGGNFEKIKGQRKRQLSEYSSDASTKSRKPKGMQELTDEYGDLDDSALDAEGPAGLVYRYSRRKSDAKSDDNSQSNGDGVMMMINGELVKVEQLKREEIINCTCGITEEDGLMIQCDLCLCWQHGHCNAIERERDVPDKYICYICRNPFRGRQSKKYSHNQDWIKEGKLESLSKRTKNQEAINHRTAVLKRSYDLVGALIEIQRILHSLRVKINVVQKKDHPKLYLWAKNWEKSEIPEPQLEPVPIIEIITPKTVVDEAAAELPVKNEESDDKNEIKREDDKQISSDSELMKILEEDNSVINEAKVNCKKEEDEGKNDGRILLDALTRSEDDKKGEEVKREGDGADGEPGVPLEETIKKLQPFVPEPEAPIDPDECRLRLLEHIEHFQDHIDAQLATIEAQVDALETMEPTDDRSSDVQPRMKQTIQMLMRDLATVRKLAALC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2