Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_963921955.1
Location
OY998107.1:4215497-4226818[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 3.2e-19 1.8e-15 56.9 0.2 8 69 492 553 486 560 0.93
2 2 1.8 1e+04 -3.2 0.0 41 58 1089 1106 1089 1114 0.84

Sequence Information

Coding Sequence
ATGGCGCGTAAATGCTGCGTTAAAAATTGTAATACCAGTAGTAAAACAAGCAATAAATATGGTTTGAAACTTCACAAATTTCCAAAGGATTATTTGATAAGGGCTAAGTGGTTTGATAATTGTAGAATTGATAATGATTGCCGGGATGTGCCTGGGCCATTTATATGCTACAAACACTTTAAAAGAAGTGATTATGATATTGTTAAGGGACACAAGTATTTGCTTAAGGAAAATTCTGTGCCAAGTGTTTTTCAGGACTACGACGATCATCCTGATCCAATAATAATGCCAGTGAAGACACGAAACGTTTCATATCCTCAAGAAGATCTTGATCTCATAAATTCAAAGACAAACAATGTTGATGATAGAACCGATGGGATTGATTCTCCCGGTTACAACGACAGCTGCGGGGAAGCATGTAACTCGAGACCACAATCTTCTGCTGATTCTTTGAATCAATCAGAGAGCCAGGATGATAACGAGGCAACTGGTAAATTATTAGATATTGATTGTGAGATGGAAAAAGTTAAGAAGAGTGAGTTTAAAGAGTCACCACCAGCTGAACCGCCTCCAGTTAATTCATCTGTTAATAATCAAATGAATAATGTCAATAAAATGGAGAATACTGTTAAGAAAGACAGTAAGACAACAAAAGTGTCTAGGGgagatttgaaattttttcctggTGCCAAATTAGAGGCTAAAGACTTCAATGATCAGTGGTATGCGGCAAGAGTCGTTGAGACTGACTGGGTAGAAAGGGAAGTATTGATACATTTCGACAAGTGGAATTCGAGATTTGATGAGTGGATACCAATGGATAGTTCGAGGCTCAGGGTACTGCAGATGCAGCCTAGTGAACAAGATTGGGTCATTGCAACTCCGGAGACAAAACCCAGAGAATTTTCAGTGGGCGAAAGAATATTAGCAACATGGGCAGATGGAAGAAAGTATCCAGCCAAAGTAAAGGCACTAATGGGCAATGatCGTTACGACATATTATTTGATGATGGTTATTCAAAGGTTTTACGCTCCTCGAAGATGACTAAAATTGCTGGAACATTGGACAAGTCAAGTGGACAGCAATCAGGTATGGAGGCTGAATCATACATTGGTAGCAAGCAGGAGAGGAGAGACAAGAAGAGAAAGCACACAGTGACTGAATTATTTAACAGCAGAAAACGTACAAAAACAGAGAGCGAGAGATCATCAAAGAAAGATGATAATCACGATGAGAATGAAGCAGAAATTCATGAAGCTAATGGCAGTGGAAGTTATGATTCTGGTGCTGAGATGCTGAAGGGATTTCCAAATCAAAAGAAGATCAAGAATTACACGAAAAGGAAGAGAGAGTATCAGAAAGTTGATACTGATCAGGAATATGATGATGTTGGTCCTGAATGGGTTGATGGTGAACCACAGGGAATCGAGTCATTCACTACTGATGGCGCGAGAAGATCAATCATTGTGCCTGACAGAAGACTACCACCTGGTTGGCAGAAGCATTTTGTCCAGAGAAAGACCGGAAGTTCTGCGGGAAAATGGGACGTCCTTTTCGTTCACAAATTGAGCGGCAAGAAGTTCAGATCGAGAAATGACTTGAAGACGTACTTCGAGAGCCAGGGAATGACGAATTTCAATCCTGACATGTTCGACTTCTGCATACATCGCAAGAAAAAGGCAGGTGCAAAGAATCATACGCCAAAGCCGGAGAGTCCGGTTGAGGTGCCAAGGAAGATCAAGACACTTTTGCCAAAAACTAAGGCGAATGCTCCGGCTAGTACTGCTGATAATCTTCTGTTGACTCCTGTGACATCGGCTCTGGCTCAGTCATCACCTGCGCCTTTGCCAGTGGCTACGCCCATTGATGACAGTGCTGTGTTTATCGGAGGCCTGCGAGTAGAAATGGAGGACAGTGCTTACAAGTGTCCAATTGAAGGCTGCAGCAAGACCTTCCGCAAGGAGAATCTCCTCCAAATGCACATCAAACATTATCACAAAGAGTACTCACAGTTTGTTGGATCAACACCAAATGTCGCTGATTTAGCATACGCAAGAACAATAGGCGAATCAATTCAAGATGTTActcccaaaaaatcgaatgaaaaacGTAAATCACTTCATGAGAGGCCACTTCATTCAATTACAATGTCACCATTGACTACTTCCATTATCGATAATTCATTGACTGATAATGGAGTTGttgatggaaaattggaaatgatGTCACCGACATCGAACAGCAGCATGGATGTCACGGACGATGGTGCACATAAGAGTGAGTGCGCTATGTCACCAGGCTCACTGTTTGATATGAAgataagagaagaaaaaacgcAGACGGGAATTAAAACATTGCTACCAGTTAGACCGAGTAATAGTGATTCGCAGAGGATTGATAGGTCGAAATCGTTGGATGATGGAggcaattttgagaaaatcaagGGACAGAGGAAGAGGCAATTGTCGGAGTACAGCTCAGATGCTTCGACGAGGAGCAGAAAACCGAAAGGCATGCAGGAGCTTGCTGATGATTATGGCGATTTAGATGACAGTGCATTGGATGCTGAAGGACCAGCTGGACTTGTTTACAGATACAGTCGTAGGAAATCAGATGCTAAGAGCGACGATAATAGTCAGAGCAATGGTGATGGTGtcatgatgatgataaatggTGAACTGGTAAAAGTGGAGCAGTTAAAACGTGAGGAGATAATCAATTGTACCTGCGGAATAACGGAGGAGGATGGTCTGATGATTCAGTGTGATCTCTGTCTTTGCTGGCAGCATGGTCATTGCAATGCAATTGAGCGTGAGCGTGATGTTCCAGACAAGTATGTATGCTACATTTGCCGCAATCCTTTCCGTGGAAGACCATCCAAGAAGTACTCGCACAATCAGGACTGGataaaagagggaaaattggAGAGTTTGTCGAAACGAACGAAAAATCAAGAGGTGATTAATCACAGAACGGCTGTTTTAAAGCGTTCGTATGATCTAGTTGGTGCATTGATCGAGATTCAGCGAATTCTTCACAGTTTGAGGGTAAAAATAAACGTTGTACAGAAGAAAGATCATCCAAAGCTCTATTTATGGgcgaaaaattgggaaaaaagcGAAATTCCGGAGCCGCAACTGGCGCCAGTGCCAATAATCGAGATAATAGCACCAAAACCAGCAGCGATCGATGAAGCAGCTGTTGAATTACCACTGAAGAATGaggaaattgatgataaagaTGAAATTAAACGCGAAGTAGATAAACAAATATCATCGGATtcggaattaatgaaaatacttGAGGAAGACAGTTCTGTGATAAATGAGGCGAagattaattgtaaaaaagaggaggatgaggaaaaaaatgatgggaGAATACTGCTCGATGCTTTGACTAGAAGCGAAGATGAGAAGAAGGGGGAGGTGGTGAAGGGAGAGAGTGAGGGCGATGGAGATGTTGAAGCAGGTGTGCCTTTGGAGGAGACGATTAAGAAACTACAGCCATTTGTACCGGAACCGGAAGCACCGATTGATCCGGATGAGTGTCGGCTGAGGCTCTTGGAGCACATTGAACACTTTCAGGATCATATTGATGCACATTTGGCAACGATTGAAGCACAAGTTGATGCACTGGAGACAATGGAGCCAACCGATGATAGATCATCTGACGTACAACCACGTATGAAACAGACCATACAAATGCTATTGAGAGATCTTGCAACAGTACGAAAGTTGGCTGCTCTTTGTTGA
Protein Sequence
MARKCCVKNCNTSSKTSNKYGLKLHKFPKDYLIRAKWFDNCRIDNDCRDVPGPFICYKHFKRSDYDIVKGHKYLLKENSVPSVFQDYDDHPDPIIMPVKTRNVSYPQEDLDLINSKTNNVDDRTDGIDSPGYNDSCGEACNSRPQSSADSLNQSESQDDNEATGKLLDIDCEMEKVKKSEFKESPPAEPPPVNSSVNNQMNNVNKMENTVKKDSKTTKVSRGDLKFFPGAKLEAKDFNDQWYAARVVETDWVEREVLIHFDKWNSRFDEWIPMDSSRLRVLQMQPSEQDWVIATPETKPREFSVGERILATWADGRKYPAKVKALMGNDRYDILFDDGYSKVLRSSKMTKIAGTLDKSSGQQSGMEAESYIGSKQERRDKKRKHTVTELFNSRKRTKTESERSSKKDDNHDENEAEIHEANGSGSYDSGAEMLKGFPNQKKIKNYTKRKREYQKVDTDQEYDDVGPEWVDGEPQGIESFTTDGARRSIIVPDRRLPPGWQKHFVQRKTGSSAGKWDVLFVHKLSGKKFRSRNDLKTYFESQGMTNFNPDMFDFCIHRKKKAGAKNHTPKPESPVEVPRKIKTLLPKTKANAPASTADNLLLTPVTSALAQSSPAPLPVATPIDDSAVFIGGLRVEMEDSAYKCPIEGCSKTFRKENLLQMHIKHYHKEYSQFVGSTPNVADLAYARTIGESIQDVTPKKSNEKRKSLHERPLHSITMSPLTTSIIDNSLTDNGVVDGKLEMMSPTSNSSMDVTDDGAHKSECAMSPGSLFDMKIREEKTQTGIKTLLPVRPSNSDSQRIDRSKSLDDGGNFEKIKGQRKRQLSEYSSDASTRSRKPKGMQELADDYGDLDDSALDAEGPAGLVYRYSRRKSDAKSDDNSQSNGDGVMMMINGELVKVEQLKREEIINCTCGITEEDGLMIQCDLCLCWQHGHCNAIERERDVPDKYVCYICRNPFRGRPSKKYSHNQDWIKEGKLESLSKRTKNQEVINHRTAVLKRSYDLVGALIEIQRILHSLRVKINVVQKKDHPKLYLWAKNWEKSEIPEPQLAPVPIIEIIAPKPAAIDEAAVELPLKNEEIDDKDEIKREVDKQISSDSELMKILEEDSSVINEAKINCKKEEDEEKNDGRILLDALTRSEDEKKGEVVKGESEGDGDVEAGVPLEETIKKLQPFVPEPEAPIDPDECRLRLLEHIEHFQDHIDAHLATIEAQVDALETMEPTDDRSSDVQPRMKQTIQMLLRDLATVRKLAALC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00047963;
90% Identity
iTF_00047963;
80% Identity
iTF_00046199;