Basic Information

Insect: Aleiodes leptofemur
Gene Symbol: MBD-R2
Assembly: GCA_963942555.1
Location: OZ012612.1:4667940-4680490[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 2.5e-19 2e-15 57.0 0.3 8 69 492 553 486 560 0.93

2 2 1.6 1.3e+04 -3.3 0.0 41 58 1089 1106 1089 1112 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	2.5e-19	2e-15	57.0	0.3	8	69	492	553	486	560	0.93
2	2	1.6	1.3e+04	-3.3	0.0	41	58	1089	1106	1089	1112	0.85

Sequence Information

Coding Sequence: ATGGCGCGTAAATGCTGCGTTAAAAATTGTAATACCACTAGTAAAACAAGCAATAAATATGGTTTGAAACTTCACAAATTTCCAAAGGATTATTTGATAAGGGCAAAGTGGTTTGATAATTGTAGAATTGATAATGATTGCCGGGATGTGCCAGGGCCATTTATATGCTACAAACACTTTAAAAGAAGTGATTATGATATTGTTAAGGGACACAAGTATTTGCTTAAGGAAAATTCTGTGCCAAGTGTTTTTCAGGACTACGACGATCATCCTGATCCAATAATAATGCCAGTAAAGACACGAAACGTTTCATATCCTCAAGAAGATCTTGATCTCATAAATTCAAAGACAAACAATGTTGATGATAGAACCGATGGGATTGATTCTCCTGGTTACAACGACAGCTGCGGGGAAGCATGTAATTCGAGACCACAATCTTCTGCTGATTCTTTGAATCAATCAGAGAGCCAGGATGATAACGAGGCAACTGGTAAATTATTAGATATTGATTGTGAAATGGAAAAAGTTAAGAAGAGTGAATTTAAAGAGTCACCACCAGCTGAACCGCCTCCAGTTAATTCATCTgttaataatcaaattaaaaatgttaataaaatggAGAACACTGTTAAGAAGGATAGTAAGACAACAAAAGTGTCTAGGggagatttgaaattttttcctggTGCCAAATTAGAGGCCAAAGACTTCAATGATCAgtgGTATGCGGCAAGAGTCGTTGAGACTGACTGGGTAGAAAGGGAAGTATTGATACATTTCGACAAGTGGAATTCGAGATTTGATGAGTGGATACCAATGGATAGTTCGAGGCTCAGGGTACTGCAGATGCAGCCTAGtgaacaaGATTGGGTCATTGCAACTCCGGAGACAAAACCCAGAGAATTTTCAGTGGGCGAGAGAATATTAGCAACATGGGCAGATGGAAGAAAGTATCCAGCCAAAATAAAGGCACTAATGGGCAATGatcGTTACGACATATTATTTGACGATGGTTATTCAAAGGTTTTACGCTCTTCAAAGATGACTAAAATTGCTGGAACATTGGACAAGTCAAGTGGACAGCAATCAGGCATGGAGGCTGAATCATACATTGGTAGCAAGCAAGAGAGAAGAGACAAGAAGAGAAAGCACACAGTGACTGAATTATTTAACAGCAGAAAACGTACAAAAACAGAAAGCGAGAGATCATCAAAGAAAGATGATAATCAAGATGAGAATGAAGCAGAAATACATGAAGCAAATGGCAGTGGAAGTTATGATTCTGGTGCAGAGATGCTGAAGGGTTTTCCAAATCAGAAGAAGATCAAGAATTACacgaagagaaagagagagtatCAGAAAGTTGATACTGATCAGGAATATGATGATGTTGGTCCTGAATGGGTTGATGGTGAACCACAGGGAATCGAGTCATTCACTACTGATGGCGCGAGAAGATCAATTATTGTGCCTGATAGAAGATTACCACCTGGTTGGCAAAAGCATTTTGTCCAGAGAAAGACCGGAAGTTCTGCGGGAAAATGGGATGTTCTTTTTGTTCACAAAATGAGCGGCAAGAAGTTCAGATCGAGAAATGACCTGAAGACGTACTTCGAGAGCCAGGGAATGACGAATTTCAATCCCGACATGTTCGACTTCTGCATACATCGCAAGAAAAAGGCAGGTGCAAAGAATCATACGCCAAAACCGGAGAGTCCTGTTGAGGCACCGAGGAAGATCAAGACACTTTTGCCGAAAACTAAGGCAAATCCTCCAGCTAGTGCTGCTGATAATCTTCTGTTGACTCCTGTGACATCGGCCCTTGCTCAGTCATCACCTGCACCTTTGCCAGTGGCTACGCCAATTGATGACAGTGCTGTGTTTATCGGAGGCCTGCGAGTAGAAATGGAGGACAGTGCATACAAGTGTCCAATTGAAGGCTGCAGCAAGACTTTCCGCAAGGAGAATCTTCTCCAGATGCACATTAAACATTATCACAAAGAGTACTCGCAGTTCGTTGGATCAACACCAAACGTAGCTGATTTAGCATACGCAAGAACAATAGGCGAATCAATTCAAGATGttaccccaaaaaaatcgaatgaaaaacGTAAATCACTTCATGAAAGGCcgattcattcaattacaATGTCACCATTGACTGCTTCAATTATCGATAATTCATTGACTGATAATGGAATTgttgatggaaaattggaaatgatGTCACCGACATCGAACAGCAGCATGGATGTCACGGACGATGGTGCACATAAGAGTGAGTGTGCTATGTCACCAGGTTCACTGTTTGATATGAAgataagagaagaaaaaacgcAGACAGGAATTAAAACGTTGCTGCCAGTTAGACCGAGTAATAGTGATTCGCAGAGAATTGATAGGTCGAAATCGTTGGATGATGGGGGCAATTTCGAGAAGATCAAGGGACAAAGGAAGAGGCAATTGTCGGAGTATAGCTCAGATGCTTCGACGAGGAGCAGAAAACCGAAGGGCATGCAGGAGCTTACTGATGATTATGGAGACTTAGATGACAGTGCATTGGATGCTGAAGGACCAGCTGGACTCGTTTATCGATACAGTCGTAGAAAATCAGATGCTAAGAGCGATGATAATAGTCAGAGCAATGGTGATGGTGtcatgatgatgataaacGGTGAGCTGGTAAAAGTGGAGCAGTTAAAACGTGAGGAGATAATCAACTGTACCTGCGGAATAACGGAGGAGGATGGTCTTATGATCCAGTGTGATCTCTGTCTTTGCTGGCAGCATGGCCACTGTAATGCAATTGAGCGAGAGCGTGATGTTCCAGACAAGTACGTATGCTACATTTGCCGCAATCCTTTCCGCGGAAGACCATCCAAAAAGTACTCGCACAATCAAGACTGGataaaagagggaaaattggAGAGTTTGTCGAAACGAACGAAGAATCAAGAGGTGATCAATCACAGAACGGCTGTTTTGAAGCGCTCGTATGATCTAGTTGGTGCATTGATCGAGATTCAGCGAATTCTTCACAGTTTGAGGGTGAAAATAAACGTTGTACAGAAGAAAGATCATCCAAAGCTCTATTTATGGgcgaaaaattgggaaaaaaatgaaattccggAGCCTCAACTGGAACCAGTGCCAATAATCGAGATAATAGCACCAAAACCAGCGCCAATCGATGAAGCAGCTGTTGAATTACCActtaaaaatgaggaaattgatgataaagatGAAATTAAACGCGAAGCAGATAAACAAATATCATCGGATtcggaattaatgaaaatacttgaggaaGACAGTTCTGTGATAAATGAGGCGAAGGTTAATTGTAAAAAAGAGGAGGATGAGGGGAAAAATGATGGAAGAATACTGCTCGATGCTCTGACTAGAAGCGAAGATGATAAGAAGGGAGATGAGGTGAAGGGGGAGAGTGAGGGCGATGGAGATGGTGAACCAGGTGTGCCTTTGGAGGAGACGATTAAGAAATTACAGCCATTTGTACCGGAACCGGAAGCACCGATTGATCCGGATGAGTGTCGGCTGAGGCTCTTGGAGCACATTGAACACTTTCAGGATCATATTGATGCACATTTGGCAACGATTGAAGCACAAGTTGATGCACTGGAGACAATGGAGCCAACCGATGATAGATCATCTGACGTACAGCCACGTATGAAACAGACCATACAAATGCTATTAAGAGATCTTGCAACAGTACGAAAGTTGGCTGCTCTTTGTTGA
Protein Sequence: MARKCCVKNCNTTSKTSNKYGLKLHKFPKDYLIRAKWFDNCRIDNDCRDVPGPFICYKHFKRSDYDIVKGHKYLLKENSVPSVFQDYDDHPDPIIMPVKTRNVSYPQEDLDLINSKTNNVDDRTDGIDSPGYNDSCGEACNSRPQSSADSLNQSESQDDNEATGKLLDIDCEMEKVKKSEFKESPPAEPPPVNSSVNNQIKNVNKMENTVKKDSKTTKVSRGDLKFFPGAKLEAKDFNDQWYAARVVETDWVEREVLIHFDKWNSRFDEWIPMDSSRLRVLQMQPSEQDWVIATPETKPREFSVGERILATWADGRKYPAKIKALMGNDRYDILFDDGYSKVLRSSKMTKIAGTLDKSSGQQSGMEAESYIGSKQERRDKKRKHTVTELFNSRKRTKTESERSSKKDDNQDENEAEIHEANGSGSYDSGAEMLKGFPNQKKIKNYTKRKREYQKVDTDQEYDDVGPEWVDGEPQGIESFTTDGARRSIIVPDRRLPPGWQKHFVQRKTGSSAGKWDVLFVHKMSGKKFRSRNDLKTYFESQGMTNFNPDMFDFCIHRKKKAGAKNHTPKPESPVEAPRKIKTLLPKTKANPPASAADNLLLTPVTSALAQSSPAPLPVATPIDDSAVFIGGLRVEMEDSAYKCPIEGCSKTFRKENLLQMHIKHYHKEYSQFVGSTPNVADLAYARTIGESIQDVTPKKSNEKRKSLHERPIHSITMSPLTASIIDNSLTDNGIVDGKLEMMSPTSNSSMDVTDDGAHKSECAMSPGSLFDMKIREEKTQTGIKTLLPVRPSNSDSQRIDRSKSLDDGGNFEKIKGQRKRQLSEYSSDASTRSRKPKGMQELTDDYGDLDDSALDAEGPAGLVYRYSRRKSDAKSDDNSQSNGDGVMMMINGELVKVEQLKREEIINCTCGITEEDGLMIQCDLCLCWQHGHCNAIERERDVPDKYVCYICRNPFRGRPSKKYSHNQDWIKEGKLESLSKRTKNQEVINHRTAVLKRSYDLVGALIEIQRILHSLRVKINVVQKKDHPKLYLWAKNWEKNEIPEPQLEPVPIIEIIAPKPAPIDEAAVELPLKNEEIDDKDEIKREADKQISSDSELMKILEEDSSVINEAKVNCKKEEDEGKNDGRILLDALTRSEDDKKGDEVKGESEGDGDGEPGVPLEETIKKLQPFVPEPEAPIDPDECRLRLLEHIEHFQDHIDAHLATIEAQVDALETMEPTDDRSSDVQPRMKQTIQMLLRDLATVRKLAALC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00047963;
90% Identity: iTF_00047963;
80% Identity: iTF_00047023;