Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 0.0079 43 4.2 0.1 22 48 93 119 88 123 0.83

2 4 1.5e-05 0.081 12.9 0.0 21 52 120 151 117 152 0.89

3 4 0.017 92 3.2 0.1 21 48 148 175 146 179 0.85

4 4 4.5e-05 0.25 11.4 0.1 21 47 176 202 172 209 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	0.0079	43	4.2	0.1	22	48	93	119	88	123	0.83
2	4	1.5e-05	0.081	12.9	0.0	21	52	120	151	117	152	0.89
3	4	0.017	92	3.2	0.1	21	48	148	175	146	179	0.85
4	4	4.5e-05	0.25	11.4	0.1	21	47	176	202	172	209	0.88

Coding Sequence: ATGATGCATATCAAGAGCCTGCCACACGCACATCAGGCTGCTGCGGCAATGAGCAATTGTGACATTGTCATTCAGCCAACATCAGCCCCGCCACCGCCAACATCGCATACACTGGCTCATCTGGTGGCCAATGCGACCCACAGTCCGACAACACTCACCGGGGATGCGCACTACGTGAGCAACGGTCACTCCGGCAATGATCACGTCGGCGAGGGTAATGGCTCGAGCAGCAGTGGTGGCGGCGGCGGCGGTGGTGGTGGTGGTGGCCGAGAACAGGATAAGCCGTTCCATTGCACTGTTTGCGATAGACGCTTCAGGCAACTGAGCACACTAACCAACCATGTGAAAATCCATACCGGGGAAAAGCCCTATAAATGCAACGTTTGTGATAAGACGTTCCGTCAATCGTCAACTTTGACGAATCATCTGAAAATTCATACGGGCGAAAAGCCTTACAATTGCAACTATTGCCCCAAGCATTTCCGTCAGCTGAGCACATTGGCCAATCATGTCAAGATTCACACGGGTGAAAAGCCGTTCGAGTGCGTCATATGCAAGAAACAGTTCCGCCAATCCAGCACGCTCAACAATCACATAAAGATCCATGTCATGGACAAGGTCTACGTTCCTGTGAAGATCAAAACCGAGGAGGACGAGGGGTGA
Protein Sequence: MMHIKSLPHAHQAAAAMSNCDIVIQPTSAPPPPTSHTLAHLVANATHSPTTLTGDAHYVSNGHSGNDHVGEGNGSSSSGGGGGGGGGGGREQDKPFHCTVCDRRFRQLSTLTNHVKIHTGEKPYKCNVCDKTFRQSSTLTNHLKIHTGEKPYNCNYCPKHFRQLSTLANHVKIHTGEKPFECVICKKQFRQSSTLNNHIKIHVMDKVYVPVKIKTEEDEG

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01551209; iTF_01557933; iTF_01557770; iTF_01549074; iTF_01549232;
90% Identity: iTF_01557933;
80% Identity: iTF_01551209;