Basic Information

Insect: Xiphydria camelus
Gene Symbol: Pax2
Assembly: GCA_963678675.1
Location: OY783199.1:3082879-3097599[+]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 7e-73 8.1e-70 233.1 0.2 2 122 20 140 19 140 0.99

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	7e-73	8.1e-70	233.1	0.2	2	122	20	140	19	140	0.99

Sequence Information

Coding Sequence: ATGGATCTCAGCACCGCGTATCGATACAACCAGAACATGATGGAGTATTACACTTgCCACGGAGGAGTGAACCAGCTCGGCGGCGTGTTCGTAAACGGGAGGCCCTTGCCCGACGTGGTGAGGCAGAGGATCGTCGAGCTGGCGCACAGCGGCGTCCGACCGTGCGACATCTCCAGACAACTCAGGGTATCCCACGGCTGTGTATCGAAAATACTGTCGAGGTACTACGAAACCGGCAGCTTCAAGGCCGGAGTGATAGGAGGCTCGAAACCCAAAGTGGCGACACCGCCGGTCGTAGACGCGATCGCCAATTATAAGAGAGATAACCCGACGATGTTCGCCTGGGAGATCAGAGATCGGTTGCTCGCCGAGGGGATCTGCTCGCAGGACAACGTACCTTCCGTCTCCTCCATCAATCGGTGA
Protein Sequence: MDLSTAYRYNQNMMEYYTCHGGVNQLGGVFVNGRPLPDVVRQRIVELAHSGVRPCDISRQLRVSHGCVSKILSRYYETGSFKAGVIGGSKPKVATPPVVDAIANYKRDNPTMFAWEIRDRLLAEGICSQDNVPSVSSINR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01228961;
90% Identity: iTF_00266402; iTF_00996290; iTF_00047908; iTF_00265636; iTF_00829444; iTF_01066885; iTF_01067557; iTF_01070309; iTF_01303301; iTF_00263398; iTF_00391238; iTF_01005030; iTF_01069606; iTF_01207303; iTF_01413127; iTF_01428231; iTF_00286280; iTF_00756584; iTF_01103496; iTF_01392712; iTF_01465128; iTF_00398025; iTF_00414249; iTF_01110057; iTF_01523977; iTF_01414122; iTF_00059404; iTF_00143820; iTF_00378700; iTF_01002028; iTF_01129292; iTF_01190284; iTF_00718509; iTF_00645902; iTF_00938638; iTF_01000496; iTF_01102000; iTF_01454032; iTF_01497360; iTF_00159057; iTF_01068241; iTF_01102738; iTF_00459699; iTF_01469619; iTF_01299124; iTF_00714325; iTF_00721206; iTF_01057590; iTF_01113366; iTF_00058647; iTF_01004183; iTF_01068919; iTF_01101271; iTF_00326328; iTF_01112536; iTF_01379160; iTF_00861817; iTF_01006009; iTF_01393465; iTF_01468793; iTF_00439418; iTF_01056762; iTF_00057883; iTF_00798523; iTF_00841019; iTF_00905371; iTF_01381275; iTF_00316734; iTF_00882910; iTF_00968766; iTF_01306398; iTF_01055935; iTF_01111711; iTF_00719360; iTF_01411456; iTF_01228961; iTF_01405636; iTF_00127398; iTF_01408137; iTF_00125866; iTF_01266828; iTF_00128145; iTF_01267507; iTF_01423603; iTF_00868725; iTF_01409045; iTF_00128918; iTF_00129686; iTF_01271158; iTF_01421496; iTF_01268988; iTF_00126655; iTF_00279904; iTF_00293666; iTF_01475395; iTF_00228613; iTF_01473125; iTF_00227910; iTF_00253511; iTF_00633575; iTF_00964423; iTF_01474631; iTF_01130761; iTF_01473865; iTF_00862507; iTF_00226540; iTF_00298253; iTF_00860333; iTF_01420877; iTF_00252016; iTF_00086225; iTF_00229297; iTF_00255026; iTF_00229972; iTF_00233172; iTF_00294420; iTF_00227221; iTF_00221206; iTF_00295190; iTF_01198614; iTF_01418296; iTF_00297497; iTF_00217018; iTF_00252762; iTF_00291482; iTF_00292890; iTF_00982234; iTF_00218363; iTF_00863899; iTF_01493531; iTF_00773756; iTF_01539548; iTF_00360157; iTF_01498141; iTF_00254270; iTF_00963135; iTF_01395071; iTF_01492831; iTF_00982912; iTF_01419584; iTF_01255497;
80% Identity: iTF_00266402; iTF_00996290; iTF_00047908; iTF_00265636; iTF_00829444; iTF_01066885; iTF_01067557; iTF_01070309; iTF_01303301; iTF_00263398; iTF_00391238; iTF_01005030; iTF_01069606; iTF_01207303; iTF_01413127; iTF_00286280; iTF_00756584; iTF_01103496; iTF_01392712; iTF_01465128; iTF_00398025; iTF_00414249; iTF_01110057; iTF_01523977; iTF_01414122; iTF_00059404; iTF_00143820; iTF_01002028; iTF_01129292; iTF_01190284; iTF_00718509; iTF_00645902; iTF_00938638; iTF_01000496; iTF_01102000; iTF_01454032; iTF_01497360; iTF_00159057; iTF_01068241; iTF_01102738; iTF_00459699; iTF_01469619; iTF_01299124; iTF_00714325; iTF_00721206; iTF_01057590; iTF_01113366; iTF_00058647; iTF_01004183; iTF_01068919; iTF_01101271; iTF_01112536; iTF_01379160; iTF_00861817; iTF_01006009; iTF_01393465; iTF_01468793; iTF_00439418; iTF_01056762; iTF_00057883; iTF_00798523; iTF_00841019; iTF_00905371; iTF_01381275; iTF_00316734; iTF_00882910; iTF_00968766; iTF_01306398; iTF_01055935; iTF_01111711; iTF_00719360; iTF_01411456;