Pcal005796.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Pogonomyrmex californicus
Gene Symbol
Pax2
Assembly
GCA_017141365.1
Location
JAEVLP010004838.1:231887-240207[-]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 3.9e-73 1.2e-69 232.9 0.2 2 122 24 144 23 144 0.99

Sequence Information

Coding Sequence
ATGGACCTCAGCACTACTTTGAGTAGTGCCTACCGATACAATCAGAACATGATGGAATATTACACCTGTCATGGCGGAGTCAACCAACTCGGCGGCGTCTTTGTGAACGGAAGGCCGCTACCGGATGTAGTCAGGCAGAGGATCGTCGAGCTCGCGCACAGCGGCGTCCGACCGTGCGACATTTCGAGGCAACTCAGGGTATCTCACGGCTGTGTATCCAAGATACTGTCGAGGTATTACGAGACCGGTAGTTTTAAGGCCGGTGTCATAGGAGGTTCCAAGCCGAAAGTGGCAACGCCACCGGTCGTCGACGCGATCGCCAATTACAAGAGGGACAATCCGACGATGTTCGCGTGGGAAATCAGGGACAGATTGCTGGCCGAAGGTATTTGCTCGCAAGACAATGTGCCATCCGTCTCTTCCATCAATCGGTGA
Protein Sequence
MDLSTTLSSAYRYNQNMMEYYTCHGGVNQLGGVFVNGRPLPDVVRQRIVELAHSGVRPCDISRQLRVSHGCVSKILSRYYETGSFKAGVIGGSKPKVATPPVVDAIANYKRDNPTMFAWEIRDRLLAEGICSQDNVPSVSSINR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01405636; iTF_00127398; iTF_01408137; iTF_00125866; iTF_01266828; iTF_00128145; iTF_01267507; iTF_01423603; iTF_00868725; iTF_01409045; iTF_00128918; iTF_00129686; iTF_01271158; iTF_01421496; iTF_01268988; iTF_00126655; iTF_00279904; iTF_01537889; iTF_00266402; iTF_00996290; iTF_00047908; iTF_00265636; iTF_00829444; iTF_01066885; iTF_01067557; iTF_01070309; iTF_01303301; iTF_00263398; iTF_00391238; iTF_01005030; iTF_01069606; iTF_01207303; iTF_01413127; iTF_01428231; iTF_00286280; iTF_00756584; iTF_01103496; iTF_01392712; iTF_01465128; iTF_00398025; iTF_00414249; iTF_01110057; iTF_01523977; iTF_01414122; iTF_00059404; iTF_00143820; iTF_00378700; iTF_01002028; iTF_01129292; iTF_01190284; iTF_00718509; iTF_00645902; iTF_00938638; iTF_01000496; iTF_01102000; iTF_01454032; iTF_01497360; iTF_00159057; iTF_01068241; iTF_01102738; iTF_00459699; iTF_01469619; iTF_01299124; iTF_00714325; iTF_00721206; iTF_01057590; iTF_01113366; iTF_00058647; iTF_01004183; iTF_01068919; iTF_01101271; iTF_00326328; iTF_01112536; iTF_01379160; iTF_00861817; iTF_01006009; iTF_01393465; iTF_01468793; iTF_00439418; iTF_01056762; iTF_00057883; iTF_00798523; iTF_00841019; iTF_00905371; iTF_01381275; iTF_00316734; iTF_00882910; iTF_00968766; iTF_01306398; iTF_01055935; iTF_01111711; iTF_00719360; iTF_01411456; iTF_01390159; iTF_00343122; iTF_00011044; iTF_00209765; iTF_01394245; iTF_01213990; iTF_00377959; iTF_00379567; iTF_00967120; iTF_01110899; iTF_00381012; iTF_01422868; iTF_00264213; iTF_00381785; iTF_00707801; iTF_01422172; iTF_01234291; iTF_01513418; iTF_01514100; iTF_01234971; iTF_01233598; iTF_00687126; iTF_00996982;
90% Identity
iTF_01537889;
80% Identity
iTF_00996982;