Basic Information

Transcription Factor Domain

TF Family: E2F
Domain: E2F_TDP domain
PFAM: PF02319
TF Group: Helix-turn-helix
Description: This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 7.9e-30 4e-26 91.0 0.2 2 65 10 74 9 74 0.98

2 3 0.74 3.8e+03 -1.8 0.0 9 38 81 110 78 112 0.77

3 3 0.39 2e+03 -0.9 0.0 16 40 177 207 138 209 0.54

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	7.9e-30	4e-26	91.0	0.2	2	65	10	74	9	74	0.98
2	3	0.74	3.8e+03	-1.8	0.0	9	38	81	110	78	112	0.77
3	3	0.39	2e+03	-0.9	0.0	16	40	177	207	138	209	0.54

Coding Sequence: ATGGCAGACAATCAGCaaagtagatttgaaaaatCTCTCGGATTACTGACCACACGGTTCGTCACGTTACTGCAAAAGGCCAAGGATGGTGTTCTCGATCTAAAAGTGGCTGCAGATATCTTGGAGGTTCGTCAAAAGAGACGAATATACGATATTACAAATGTTCTCGAAGGTATAGGACTCATCGAGAAGAAGAGCAAGAATAGTATACAGTGGAAGGGTGCAGGACCGGGATGCAATACTCAAGAGGTTGGAGAAAAATTATCCGATCTGAAGGAAGAAATTAAAAGATTGGAGGAGCACGAAGATCAGTTAGATACACATACTCGATGGATTCGACAAAGCGTGAAAAATATCGAAAGCGATTTTACGAACAGAAGTTACGCGTACATTACATACGAGGATGTCAAAGAAAAGTTTGCCGATAAATTTGTGTTGGGTATCCAGGCCCCTTCGGATACGCAGCTGAGCGTTCCTAATGTTAGCAAGGCTGTGGAACAGGACGAGAGGAACGTCAATTATGAGATCTTTATGAGAAGTTCCTCCGGGGAAATAAAGGTTTACACGATTCAGCCGGAATTGGCCGAAACTTATGAGAGTCTGGTGACGGAGAGGAGACTCCAGGAAAAGTCAAAGGGTAttaagagagagaaggaagagGATGAGAAGAAAGAAGATTCCAGGCCAAAGAGAAAAGTTGGAAGCGCAAGTATTCTGTACAGGCCACCTAGAGGGTCCAGCAAAATTGATCCCGTATTGtcggacgacgaagaagaagaggataCGGAATTAATAGAAGCCAAAATTATACTTAGCGACGTTGGCACGTCGGATCTCGGTAGGACCGAATTGGACCTGTTGGGCGAATTTTATTCGGATATCTGCGGACCGTTGGTAAGGCTGAGTCCGCCACCCGGAGAAAAGGATTATCAATTCAATCTCGGCGAAAACGAAGGTATTTGCGACCTGTTCGACATAGCGACAAAGTGA
Protein Sequence: MADNQQSRFEKSLGLLTTRFVTLLQKAKDGVLDLKVAADILEVRQKRRIYDITNVLEGIGLIEKKSKNSIQWKGAGPGCNTQEVGEKLSDLKEEIKRLEEHEDQLDTHTRWIRQSVKNIESDFTNRSYAYITYEDVKEKFADKFVLGIQAPSDTQLSVPNVSKAVEQDERNVNYEIFMRSSSGEIKVYTIQPELAETYESLVTERRLQEKSKGIKREKEEDEKKEDSRPKRKVGSASILYRPPRGSSKIDPVLSDDEEEEDTELIEAKIILSDVGTSDLGRTELDLLGEFYSDICGPLVRLSPPPGEKDYQFNLGENEGICDLFDIATK

Sequence clustering based on sequence similarity using MMseqs2