Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.07 1.1e+02 4.6 0.3 22 45 97 120 84 124 0.83

2 8 0.18 2.9e+02 3.2 0.0 21 44 124 147 120 155 0.87

3 8 0.29 4.7e+02 2.6 0.1 21 45 152 176 150 183 0.85

4 8 0.067 1.1e+02 4.6 0.1 21 48 180 206 177 211 0.86

5 8 0.23 3.8e+02 2.9 0.0 18 44 205 231 203 239 0.79

6 8 0.18 2.8e+02 3.3 0.1 23 52 238 267 235 269 0.87

7 8 0.017 28 6.5 0.1 23 51 266 294 256 295 0.87

8 8 0.00031 0.49 12.1 0.0 22 45 293 316 290 320 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.07	1.1e+02	4.6	0.3	22	45	97	120	84	124	0.83
2	8	0.18	2.9e+02	3.2	0.0	21	44	124	147	120	155	0.87
3	8	0.29	4.7e+02	2.6	0.1	21	45	152	176	150	183	0.85
4	8	0.067	1.1e+02	4.6	0.1	21	48	180	206	177	211	0.86
5	8	0.23	3.8e+02	2.9	0.0	18	44	205	231	203	239	0.79
6	8	0.18	2.8e+02	3.3	0.1	23	52	238	267	235	269	0.87
7	8	0.017	28	6.5	0.1	23	51	266	294	256	295	0.87
8	8	0.00031	0.49	12.1	0.0	22	45	293	316	290	320	0.91

Coding Sequence: ATGTCTTCTTGCGATCCAgttaaaattgaattaaaagACGATGTGAGGGACATAGAGATGGAAGAAAAGTTTATTGTAGATGAAGCAGTGAAAGAGGCATTTGTCGAGCCCAATTTTTGTATACAGGACAATAAGGCAGATGGAAATAAGGATGAAATAATTGCTGAAGCAAAAGAGACTGTTAaagcaaaaattgaaaatgaaggGAATAAATTCAAATGTCCCGATTGCTCGAAAGCCTACGCGAATGCCAGTGGATTACGAAGCCATTCCAGTGTTCATACTGGAGCGAGACCCTACGAGTGCAAGATATGCCATAAATCGTTCCGTCTGGCGCAAATTTTAAAGTCTCATTTGCGCTATCACACCGGGGAAATGCcttacaaatgcgaaatttgtaaaaaaggaTTTTGCACCAATTCTAACTTGAAAAGCCACTTGATGGGTCACACGGGAGAGAAGCCGTACAATTGCGCGGTTTGTAAAAAAGGGTTCTGTCGTTCCGAAAGTCTGAAGAGTCACATGATGTGTCACACTAAGGAGAAGCCTTACGAGTGCGAAATTTGTAGAAAAACGTTCGGTCTCCCCCAAAATTTAAAGAATCATATGATGCGTCACACGGgagaaaagccccacaaatgtgaaatttgtaaaaagTCGTTCGGTCTAAATGGGCATATAAAGAGACATATGATGGGTCACACAAACGTAAAGCCtcacaaatgcgaaatttgtaaaaaaacgTTTCGCGAGTTTTCCTATCTAAAGAATCATATGGTGTGCCACTCGGTCGTAAAGCCCTACAAATGCGACATTTGTGAAAAAACATTCGGTCGCTCCCACGTTTTAAAGCGACATATCTTGTTGCACACGAGAGAgaagccttacaaatgtgaaatttgtaaaaaattctTCAGTCAATCTGCGAATCTAAAGAAACATGTGAAATGCCACACAAGACGAGAAACCACTTTAACATCAGTTATGCACGAAAAGTTTTCTACGCGAGTTGATGGTGATGAACAGATCATAGCATAG
Protein Sequence: MSSCDPVKIELKDDVRDIEMEEKFIVDEAVKEAFVEPNFCIQDNKADGNKDEIIAEAKETVKAKIENEGNKFKCPDCSKAYANASGLRSHSSVHTGARPYECKICHKSFRLAQILKSHLRYHTGEMPYKCEICKKGFCTNSNLKSHLMGHTGEKPYNCAVCKKGFCRSESLKSHMMCHTKEKPYECEICRKTFGLPQNLKNHMMRHTGEKPHKCEICKKSFGLNGHIKRHMMGHTNVKPHKCEICKKTFREFSYLKNHMVCHSVVKPYKCDICEKTFGRSHVLKRHILLHTREKPYKCEICKKFFSQSANLKKHVKCHTRRETTLTSVMHEKFSTRVDGDEQIIA

Sequence clustering based on sequence similarity using MMseqs2