Basic Information

Gene Symbol
MBD3
Assembly
GCA_950022955.1
Location
OX465565.1:13439348-13443202[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 4.4e-28 2.7e-24 86.1 0.1 1 72 8 74 8 78 0.95
2 2 0.00026 1.6 10.0 0.1 29 73 96 148 81 151 0.87

Sequence Information

Coding Sequence
ATGAGTACAATGAATATATCTATAGAGAAGAAAAGATCGGACTGCCCTGCCTTACCCAAAGGTTGGCAAAGGGAAGAAGTTCTCAGGAAAACAGGCTTATCTGCCGGAAAAGTTGATGTTTACTATTACAGCCCAACAGGTAAAAAGTTTCGCAGTAAGGCTGAGCTAGTTCGTTATCTGGGTGATAGTATGGACCTGTCGTGTTTCGACTTTCAGCAGGGTCAGATAAACACAATGCTGCTGTGCAAGGCCAAGAAAGCACGCGCGCAGTTTGACTACAGgGGAGTCCGATCGGATGCGTCTTTGGTACCTCCTATTCGTCAAACGGCGTCAATATTCAAGCAGCCTGTTACTGTCTATAAGACACAGGAAAGCAAGGTGAAAACTGACCTGAAACATGGTACACAAGAGAAACCCAAACAGCTGTTCTGGGAAAAGAGGCTAgaaTACTTTAAGATCATTCCACAGTACTGTTTCTTTATGGAAGTTTTCCTTGAAGTTGTATCCCCACTGCTCTTGAAGTTGTTTGAGATTTAA
Protein Sequence
MSTMNISIEKKRSDCPALPKGWQREEVLRKTGLSAGKVDVYYYSPTGKKFRSKAELVRYLGDSMDLSCFDFQQGQINTMLLCKAKKARAQFDYRGVRSDASLVPPIRQTASIFKQPVTVYKTQESKVKTDLKHGTQEKPKQLFWEKRLEYFKIIPQYCFFMEVFLEVVSPLLLKLFEI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2