Basic Information

Gene Symbol
MBD3
Assembly
GCA_949128165.1
Location
OX421915.1:6701243-6703741[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.8e-26 2.5e-22 79.5 0.1 1 72 5 71 5 76 0.94
2 2 8.9e-05 0.81 10.6 0.0 29 74 93 146 78 148 0.86

Sequence Information

Coding Sequence
ATGAATATATCAATTGAAAAGAAACGTTCCGAGTGTCCTGCACTGCCTAAAGGCTGGCAAAGGGAAGAAGTTTTGAGAAAAACTGGGTTATCTGCTGGGAAGGTTGATGTATACTACTATAGCCCTACAGGTAAAAAGTTTCGCAGTAAGCCTGAGCTAGTGCGTTCTCTGGGTGATAGTATGGACCTATCGTGTTTCGACTTCCAACAGGGTCAGATAAACACTATGTTGCTGTGCAAGGCCAAGAAAGCGCGAGCGCAGTTTGATTACAGGGGGGTTCGCTCGGACGCGTCGCTAGTGCCACCTATCCGACAAACGGCTTCGATATTCAAACAGCCAGTGACTGTGTATAAGACTCAGGAGAGCATGGTAAAGACTGACTTGAAGCATGGCACCACGGAAAAACCGAAACAGCTGTTTTGGGAGAAGAGATTAGAGGTAATCCTAGCCAGTTAG
Protein Sequence
MNISIEKKRSECPALPKGWQREEVLRKTGLSAGKVDVYYYSPTGKKFRSKPELVRSLGDSMDLSCFDFQQGQINTMLLCKAKKARAQFDYRGVRSDASLVPPIRQTASIFKQPVTVYKTQESMVKTDLKHGTTEKPKQLFWEKRLEVILAS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01532037;
90% Identity
-
80% Identity
-