Xict025847.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Xanthia icteritia
Gene Symbol
tc1a
Assembly
GCA_949128155.2
Location
OX421949.2:9857094-9883645[-]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.9e-08 5e-05 24.4 0.1 25 67 10 53 5 105 0.85

Sequence Information

Coding Sequence
ATGGATACCACTGCAGATGAAGCCGCTCAAGTCATTGCACTACTGCAATCAGGGATGCGGCAATGTGATGTTGCTCGGCAACTGAACTTAAGTCGTTTTTCCGTTCGACGAGTGTTCCAACGCTTCCAAGAGACTGGTGGCTATATCCGAAGACGTGGATCTGGAAGACAACGGTGCACATCCGAAAGAGACGATCGCTTCATGGTTTCGACGTCTTTACGTAATCGGTTCTCCAATGCTGTTGAGCTGCAACAACAACTGCGATCAGCTCGCAGAACTTCTGTAAGCGTCTCCACGATTAGAAAAAGAATGCGGGAGAAGAAAATTGCAGCTCACAGGGCTGCTACAGGGCCAAAATTGACTGCACAGCATAAGAGAGACCGGTTGCAATTTGCCCGTGACCATGTGGATTGGACAATAGACCAATGGAGAGCTGTGCTCTTCTCGGATGAGACGAGGGTGTGTCTTTTCTGCAGCGACAGGCGTAGAAGAGTGTACAGGAGGCAAGGGGAACGATTCGCACAAGCCTGTATTCAAGAGACAGTGGAATACGGGGTTGGCTCGTGCATGTTCTGGGGCGGCATGTCAATCGACGGCAAAACGAACCTTGTGTGTGTTTCTCGGACTGGAAGTGCTCGTGGGCAAGGGTCGCTGACTGCTCATCGGTACATAACAGAGATCTTAGAGGAGCAGGTTGTCCCTTATGCGGGTTGTGTTGGCAGTGGGTTCACGTTAATGCACGATAACGCCCGCTGTCACACCGCATTTATTGTAAGTGACTACCTGCAAGAAGTTGGGATCCCTGTTGTGCGCTGGCCGGCGCATAGTCCACACCTGAACCCTATTGAGCACCTTTGGGATGAACTGAAACGGCGAGTACGGGCACGTGATCCTGCCCCTACCACTCTCCAAGACCTCCAAGATGCCGTCGTTGCAGAATGGGACAACATTCCTCAAGACACTGTTGTCATATTAATTAGGTCCATGAGAGAACGCATGGAAGCAGTCATCAGGGCTAggggGTGTTTAGCGGTAGTAGCGGCCTGCGTGCTGGCTGCGGCGCTGGTCTCAGCGCAGATCACATTCAGCCGCGACTGGACCGGCGGGAAGCGAGCAGCCCCGCAGCTTGCCCTCGACTGCGGCCAGTTTACCAGGCTATGTCGCCACTTCGTACACGAATTGAAGCAAGCCATGACGTCAGAGCTGGCCAGCAAGCATCACAGCGAGCTGGACAAACCGCCGCTCTACGACGAGGAATAG
Protein Sequence
MDTTADEAAQVIALLQSGMRQCDVARQLNLSRFSVRRVFQRFQETGGYIRRRGSGRQRCTSERDDRFMVSTSLRNRFSNAVELQQQLRSARRTSVSVSTIRKRMREKKIAAHRAATGPKLTAQHKRDRLQFARDHVDWTIDQWRAVLFSDETRVCLFCSDRRRRVYRRQGERFAQACIQETVEYGVGSCMFWGGMSIDGKTNLVCVSRTGSARGQGSLTAHRYITEILEEQVVPYAGCVGSGFTLMHDNARCHTAFIVSDYLQEVGIPVVRWPAHSPHLNPIEHLWDELKRRVRARDPAPTTLQDLQDAVVAEWDNIPQDTVVILIRSMRERMEAVIRARGCLAVVAACVLAAALVSAQITFSRDWTGGKRAAPQLALDCGQFTRLCRHFVHELKQAMTSELASKHHSELDKPPLYDEE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01246894;
90% Identity
iTF_01061857; iTF_01246913; iTF_01246945; iTF_00039778; iTF_01061858; iTF_01246914; iTF_00039779; iTF_01061859; iTF_01246915; iTF_00039780; iTF_00906116; iTF_01061860; iTF_01246916; iTF_00039781; iTF_00906117; iTF_01061861; iTF_01246917; iTF_01439909; iTF_00039782; iTF_00374086; iTF_00906118; iTF_01061862; iTF_01246918; iTF_00039783; iTF_00374087; iTF_00906119; iTF_01061863; iTF_01246919; iTF_00906120; iTF_01061864; iTF_01246920; iTF_01061865; iTF_01246921; iTF_01246922; iTF_01246923; iTF_01246924; iTF_00906126; iTF_01246894; iTF_01246926; iTF_00237551; iTF_01246927; iTF_01342191; iTF_00172912; iTF_01246928; iTF_01246929; iTF_01246931; iTF_00049876; iTF_01246932; iTF_00049877; iTF_01246901; iTF_01246933; iTF_00036694; iTF_00049878; iTF_01246902; iTF_01061847; iTF_01246903; iTF_01246935; iTF_00831192; iTF_01061848; iTF_01246904; iTF_01061849; iTF_01246905; iTF_00374074; iTF_01061850; iTF_01246906; iTF_00374075; iTF_01061851; iTF_01246907; iTF_00374076; iTF_01061852; iTF_01221532; iTF_01246908; iTF_00357469; iTF_00831197; iTF_01061853; iTF_01246909; iTF_01527197; iTF_00374078; iTF_01061854; iTF_01221534; iTF_01246910; iTF_00374079; iTF_00831199; iTF_01061855; iTF_01246911; iTF_01527199; iTF_00357472; iTF_00831200; iTF_01061856; iTF_01246912; iTF_01527153; iTF_01527156; iTF_00036695; iTF_00036679; iTF_00036687; iTF_01221530; iTF_00906122; iTF_01221531; iTF_01221536; iTF_01246944; iTF_01246930;
80% Identity
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