Pfla041759.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Polymixis flavicincta
Gene Symbol
-
Assembly
GCA_949987655.1
Location
OX465201.1:964268-965308[-]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 2.9e-08 1.4e-05 26.4 0.2 25 69 10 55 5 105 0.75

Sequence Information

Coding Sequence
ATGGATACCACTGCAGATGAAGCCGCTCAAGTCATTGCACTACTGCAATCAGGGATACGGCAATGTGATGTTGCTCGGCAACTGAACTTGAGTCGTTTTGCCGTTCGACGAGTGTTCCAACGCTTCCAAGAGACTGGTGGCTATATCCGAAGACGTGGATCTGGAAGACAACGGTGCACATCCAAAAGAGACGATCGCTTCATTGTTTCGACGTCTTTACGTAATCGGTTCTCCAATGCTGTTGAGCTGCAACAACAACTGCGATCAGCTCGCAGAACTTCTGTAAGCGTCTCCACGATTAGAAGAAGAATGCGGGAGAAGAAAATTGCAGCTCATAGGGCTGCCACAGGGCCAAAATTAACTGCACAGCATAGGAGAGACCGGTTGCAATTTGCCcgtgaccatgtggattggacaATAGACCAATGGAGGGCTGTGCTCTTCTCGGATGAGACGAGGGTGTGTCTTTTCTGCAACGATAGGCGTCGAAGAGTGTATAGGAGGCAAGGGGAACGATTCGCGCAAGCCTGTATTCAAGAGACAGTGGAATACGGGGGTGGCTCGTGCATGTTCTGGGGCGGCATGTCAATCGAGGGTAAAACGAACCTTGTGTGCGTTTCTCGGGCTGGAAGTGCTCGCGGGCAAGGGTCGCTGACTGCTGCTCGGTACATAACAGAGATCTTAGAGGAGCAGGTTGTCCCTTATGCTGGGTTTGTTGGCAGTGGGTTCACGTTAATGCACGATAACGCGCGCTGTCCCACCGCTTTAATTGTAAGAGACTACCTGCAAGAAGTTGGAATCCCTGTTATGCGCTGGCCGGCGCGAAGTCCAGACCTGAACCCTATTGAGCATCTTTGGGATGAACTGAAACGGCGAGTACGGGCACGTGATCCTGCCCCTACCACTCTCCAAGACCTCCAAGATGCCGTCGTTGCAGAATGGGACAACATTCCTCAAGAGACTGTTGTCACATTAATTCGGTCCATGAGAGGACGCATGGAAGCAGTCATCAGGGCTAGAGGGGGTAACACTaggttttaa
Protein Sequence
MDTTADEAAQVIALLQSGIRQCDVARQLNLSRFAVRRVFQRFQETGGYIRRRGSGRQRCTSKRDDRFIVSTSLRNRFSNAVELQQQLRSARRTSVSVSTIRRRMREKKIAAHRAATGPKLTAQHRRDRLQFARDHVDWTIDQWRAVLFSDETRVCLFCNDRRRRVYRRQGERFAQACIQETVEYGGGSCMFWGGMSIEGKTNLVCVSRAGSARGQGSLTAARYITEILEEQVVPYAGFVGSGFTLMHDNARCPTALIVRDYLQEVGIPVMRWPARSPDLNPIEHLWDELKRRVRARDPAPTTLQDLQDAVVAEWDNIPQETVVTLIRSMRGRMEAVIRARGGNTRF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01246930; iTF_01083301; iTF_01221529; iTF_00172902; iTF_01208157; iTF_00036686; iTF_00172910; iTF_01061857; iTF_01085185; iTF_01246913; iTF_01246945; iTF_00039778; iTF_00906114; iTF_01061858; iTF_01246914; iTF_00039779; iTF_00906115; iTF_01061859; iTF_01085187; iTF_01246915; iTF_00039780; iTF_01061860; iTF_01085188; iTF_01246916; iTF_00039781; iTF_00906117; iTF_01061861; iTF_01085189; iTF_01246917; iTF_01285509; iTF_01439909; iTF_00039782; iTF_00906118; iTF_01061862; iTF_01085190; iTF_01246918; iTF_00039783; iTF_00374087; iTF_00906119; iTF_01061863; iTF_01085191; iTF_01246919; iTF_00906120; iTF_01061864; iTF_01085192; iTF_01246920; iTF_01285512; iTF_01061865; iTF_01085193; iTF_01246921; iTF_00906122; iTF_01085194; iTF_01246922; iTF_01085195; iTF_01246923; iTF_01085196; iTF_01246924; iTF_01085197; iTF_00906126; iTF_01030190; iTF_01085198; iTF_01246926; iTF_00036687; iTF_00237551; iTF_00785167; iTF_00906127; iTF_01085199; iTF_01246927; iTF_01342191; iTF_00172912; iTF_01085200; iTF_01246928; iTF_01085201; iTF_01246929; iTF_00683314; iTF_00785170; iTF_01030194; iTF_01085202; iTF_00785171; iTF_01085203; iTF_01246931; iTF_00049876; iTF_00681620; iTF_01246932; iTF_01527156; iTF_00049877; iTF_00785173; iTF_01085205; iTF_01246901; iTF_01246933; iTF_00036694; iTF_00049878; iTF_00785174; iTF_01061846; iTF_01246902; iTF_00706935; iTF_01061847; iTF_01246903; iTF_01246935; iTF_00706936; iTF_00783448; iTF_00785176; iTF_00831192; iTF_01061848; iTF_01246904; iTF_00706937; iTF_00783449; iTF_00785177; iTF_00831193; iTF_01061849; iTF_01246905; iTF_01246937; iTF_00374074; iTF_00706938; iTF_01061850; iTF_01221530; iTF_01246906; iTF_00357467; iTF_00374075; iTF_01061851; iTF_01221531; iTF_01246907; iTF_00374076; iTF_01061852; iTF_01221532; iTF_01246908; iTF_00357469; iTF_00831197; iTF_01061853; iTF_01085181; iTF_01246909; iTF_01527197; iTF_01061854; iTF_01085182; iTF_01221534; iTF_01246910; iTF_00374079; iTF_00831199; iTF_01061855; iTF_01085183; iTF_01246911; iTF_01527199; iTF_00357472; iTF_00831200; iTF_01061856; iTF_01221536; iTF_01246912; iTF_01246944; iTF_00357473; iTF_01221542; iTF_01221541; iTF_01285513; iTF_00447114; iTF_01246925; iTF_01334831; iTF_01030192; iTF_01334832; iTF_00785169; iTF_00785172; iTF_00831188; iTF_01085204; iTF_01246900; iTF_00831189; iTF_00357465; iTF_00357471; iTF_00010032; iTF_00374078; iTF_00374086; iTF_01525991; iTF_00172918; iTF_00831190; iTF_00036695; iTF_00785175; iTF_01076475; iTF_00758137; iTF_01076474; iTF_00172913; iTF_01441061; iTF_01246940; iTF_01246941;
90% Identity
iTF_01525991;
80% Identity
-