Basic Information

Gene Symbol
MBD2
Assembly
GCA_960531455.1
Location
OY482672.1:121844316-121846754[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 5.2e-27 4.9e-23 81.9 0.0 1 72 7 73 7 87 0.93
2 3 0.00062 5.8 7.9 0.0 29 72 236 290 217 295 0.79
3 3 1.9 1.8e+04 -3.2 0.0 36 45 297 306 297 308 0.80

Sequence Information

Coding Sequence
ATGAGTTCAAGCATTACAATAGAACGTAAGCGAGTAGATTGTAATGCTTTGCCAAAGGGCTGGCAAAGGGAGGAGGTTTTACGTAAATCCGGCATATCGGCTGGGAAAGTGGATGTCTACTATTACAGTCCAACTGGTAAACGAATCGAAAGTAAGCCACAATTGGCAAGATACCTTGGCGATGCTATCGATATTTGTGCATTCGATTTTCAAAGCGGCAAATTCGTACGTCACTTGCCGCCACCTTCGATTTCACTATTCCGTTGTAGCAGTAGCGGCAGTTTAACTATCACCACCGCCAACAGCGGTACCGTTGGTAGTGATACCATATCAATGCCACCACCTCCGCCACAATGCAATAACAGTAGTGCCAACAACAGCACTTTGTCCCTATCCGTTCCTTACTACACCACAAATACTACACAATTGCCAATCACTACAAATGCCAATCCATTGCATTCGCCAATGtctacaacaacagcaacaactagTACATCAAATGCGTTAAAGCGCAAATATAAGTCACAATCCCAATCCCAAATGCATAGCCCCAATCAAATGTCATCGCTAGGCCATCAGATGCCGCAGGGCACACATACGATTGCCATAAGTAGCAGTTGTGGCTCAACGGGTGCATCTGGTGCTGTCAATAGTAGTACATCGACATCAGCAATTTCACGTCAGCAATTAGAATTCAGTCGTACGCCGCGCACAGACGCCGCACTGGTACCACCCATCCGACAGACTGCCTCGATTTTCAAACAACCCGTTACGGTGGTACGCAATCATGAGCATACAAAAGTGCGAAATGATAATACAAAACAGACAAGTGGCCAAGAGAAGCCGAAGCAAATGTTCTGGGAGAAACGTTTGGAGGGTTTGCGCGCCTGCCACCCCACCGGCGAAGAGTTCGAGGATATCGTGCTACCAAAAAGTATACGCGCCATTGGTCCGAATGTTAGCGAACAAACTGTATTACAATCGTTGGCCACGGCTTTGCACGTACTCAATGTGCCGGTTATGGGCCAAGCATCTACCAAGACTGAGATGAATAAGAATGCAACGGCATTCTTAAATCCCGAACAACCACTAATGCAGGCGGTATTGGTGTCGGATGAAGATATACGCCGGCAGGAGGAACGTGTGAATGCGTCACGTAAAAAGCTGCAGGATGCACTTAAAGCTTAG
Protein Sequence
MSSSITIERKRVDCNALPKGWQREEVLRKSGISAGKVDVYYYSPTGKRIESKPQLARYLGDAIDICAFDFQSGKFVRHLPPPSISLFRCSSSGSLTITTANSGTVGSDTISMPPPPPQCNNSSANNSTLSLSVPYYTTNTTQLPITTNANPLHSPMSTTTATTSTSNALKRKYKSQSQSQMHSPNQMSSLGHQMPQGTHTIAISSSCGSTGASGAVNSSTSTSAISRQQLEFSRTPRTDAALVPPIRQTASIFKQPVTVVRNHEHTKVRNDNTKQTSGQEKPKQMFWEKRLEGLRACHPTGEEFEDIVLPKSIRAIGPNVSEQTVLQSLATALHVLNVPVMGQASTKTEMNKNATAFLNPEQPLMQAVLVSDEDIRRQEERVNASRKKLQDALKA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01045464;
90% Identity
-
80% Identity
-