Basic Information

Gene Symbol
Aef1
Assembly
GCA_949775025.1
Location
OX459028.1:19264133-19267299[-]

Transcription Factor Domain

TF Family
zf-GAGA
Domain
zf-GAGA domain
PFAM
PF09237
TF Group
Zinc-Coordinating Group
Description
Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 0.0018 27 6.3 0.1 18 48 160 190 149 194 0.83
2 4 2.5e-05 0.37 12.2 0.0 21 50 191 220 189 222 0.87
3 4 0.00054 8 7.9 0.0 21 51 219 249 217 250 0.88
4 4 0.00014 2.1 9.8 0.1 21 47 247 273 244 278 0.89

Sequence Information

Coding Sequence
ATGCATATTAAAAGCTTACAACATGCACACGCTGCTGCGGCTATGGCCAATTGTGAAATAGTCATTGTTGCTGCCTCACCTAATCATGTCAACGAAAGTGCTGCCGcagctgcagctgctgctgctagtgctcagcagcaacaacagcaacagcaacaacaacatcaacaacaacagcaacaacaacagcagcagcagcaacaacaacaaaaccatACTACTGAAATTCAATTACCATTTAATGTCCATCTAACTGCTGCCAGTGCTGAGGCTCATGCAGCAGCTCAAGCAGCTGCTATGGCAGCGGCTCAAGCAGCAGCCGCTCAAGCTGCCGCCGCTGAAGCACATCAACAACATCCTGGCCATCATCATACAATGATACAGCAACATCCGTTATCACATCTTGTCGCTACGGCCAGCACAAGTCCTACTATATCCGAGGATCATTATATCGGTGGTGATCGTAATGGTCATCATAATTCTGGTCCTGAAAAACCCTTCCAATGCAACGTTTGCGAACGGCGATTTCGCCAATTGAGCACATTAACCAATCATGTAAAGATACATACTGGCGAAAAACCTTACAAATGTAACATTTGTGATAAGACCTTCCGTCAGTCGTCCACTCTAACAAATCACATGAAAATCCATACCGGCGAAAAACCATTTACGTGCACCTATTGCCCAAAGAATTTCCGGCAGCTAAGCACGTTGAcgaatcatttaaaaattcatacaggTGAAAAACCTTTCGAATGCGCCGTCTGCAAAAAACAATTCCGCCAGTCTAGCACACTTAATAATCATATAAAGATTCATGTTATGGATAAGGTTTACTTGCCCATGAAAATCAAAACGGAGGAGGATGAAGGATGA
Protein Sequence
MHIKSLQHAHAAAAMANCEIVIVAASPNHVNESAAAAAAAAASAQQQQQQQQQQHQQQQQQQQQQQQQQQNHTTEIQLPFNVHLTAASAEAHAAAQAAAMAAAQAAAAQAAAAEAHQQHPGHHHTMIQQHPLSHLVATASTSPTISEDHYIGGDRNGHHNSGPEKPFQCNVCERRFRQLSTLTNHVKIHTGEKPYKCNICDKTFRQSSTLTNHMKIHTGEKPFTCTYCPKNFRQLSTLTNHLKIHTGEKPFECAVCKKQFRQSSTLNNHIKIHVMDKVYLPMKIKTEEDEG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00625175;
90% Identity
iTF_00972559;
80% Identity
iTF_01486585;