Basic Information

Gene Symbol
ZFX
Assembly
GCA_000599845.3
Location
NW:974699-983298[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 2.3 37 4.6 3.2 1 23 963 986 963 986 0.87
2 13 0.013 0.22 11.6 0.1 2 23 1102 1123 1102 1123 0.98
3 13 6.5e-05 0.0011 18.9 2.2 2 23 1126 1147 1125 1147 0.97
4 13 0.017 0.29 11.2 0.5 1 23 1153 1175 1153 1175 0.97
5 13 8.7e-05 0.0014 18.4 4.5 2 23 1182 1203 1181 1204 0.95
6 13 0.39 6.3 7.0 3.7 5 23 1217 1235 1216 1235 0.97
7 13 0.0018 0.029 14.3 5.0 3 23 1242 1263 1241 1263 0.96
8 13 0.054 0.88 9.7 0.8 2 23 1279 1299 1278 1299 0.97
9 13 0.00015 0.0024 17.7 1.2 1 20 1305 1324 1305 1327 0.92
10 13 4.6e-05 0.00075 19.3 1.1 1 23 1335 1357 1335 1357 0.99
11 13 0.041 0.68 10.0 3.4 1 23 1363 1385 1363 1385 0.97
12 13 7.5e-06 0.00012 21.8 4.3 1 23 1391 1413 1391 1413 0.99
13 13 0.0011 0.017 15.0 7.2 1 23 1419 1441 1419 1442 0.96

Sequence Information

Coding Sequence
atggaTCTCACTAGAGCTGTAAGCACAATGGCAACTAATCCTTCATCAGGAAGTGGAAAAGTGGCGTGTCCCGTCTGTACCTTATACCTTCGAGAAGGTATAAGTTTACAGGAACATTTGGATACTCATCCAAAAGAACAAGTTATTGAGGCACTCATAAGAGCAAGTAGTTCTGGTTTACCATTATCGAACCAGCAAACGCCATCACCTTCacaacaaaaaagttctcCAACATCTCAAGCATCACAAACAGCATTGCCTGATGTCAGTGTACCCTCAAGCCCAACAGTATCACAAGGTCCACATATAACACCTCAACATCCATCAGCGCCTTATCCAGTAGGACCAATATATGAATGCCCACCTATGATACCCCCACATTTTACAAGCTACAGTTATCAACATTATGTCAATGGTGTTTTCTCATCAGGTGCAAGTCCCATGGTGATGCCTCAGTATGCTGTAGCTCAACCACAAAATCCACAAACAAGTCAGATGATGCAGATGGTATATAATCCATTCAGTATGTATCATCAACAACTGCAGCCTGCAGTGCAAATGATTTCAAGCCCAACGCAACAGTTACCTCATCCTTCAACACTTGCAACACCTCTGATATCTACAACATCAACAGCAACTACAGCTGTTTCAGCTCCAATCTCAGCTAGTATAGCTCCCAGGACAAGGATGAACACACCAACTAGTAGTGCTTGTATAAGTGAAGTTATTCAACCGACTTCTACTTTAGCTATATCAGAGTCAACACCAAGATGcttagaaaaatcaaaagaaactACAATTGTTCCAGATATTAGCAATGACCAAATATTACCAGATCTCGAAGTTACTTCAGCATCTGAAACCAGCTCTAAAAACCAAGaacataatgaaaatattgagaaCCCAGAAGAACAAGTTCAACGTAAAGAGTGTTCGCAACCAAAAGAATGTCACAACGAAAATTATGAATGTGAGGAGCAAACTTCATCTACGAACGATAAACTCGAGAATACCGTAAACGATGATAAAACAGAACGAATCCTTCCTGATATTGAAGATAATGATGAAATTGAATCCCTTTTGGTTCGGGAAACTTCTTCACCACAGaacgaaaaagataaaaattctgATGTACAAATGCGTGAACCTCGAGAAGTGCAGGATACAAATATAGAAGTCACACAGATTGAAATAAAtagcgataaaaatgtttcgaaaTCATCTGAATTGaatggtgaaaaaataaatgaaacgaATACTTCAGCTGAATCTGTCGAGCAACAGCTCGATAATGGTATGCAACCGACAGATCTTTCAATCAGCGAATCACGTTCTACTCAAAAGCAACCTGACATCGAAGATTTGCACCGGATCATGGAAATAATATCAGATCTAGAAAAGAAAAGCCACGTCTTACAATCTGCGTTACCTAAAAGCACCGATGAtatttgtttacaaaataGTTCCGAAAAACATTTGGAAGCAGCCTCCTCCTCACATAAACAACAGATCGATGAAGATGAAAACATGAGCAATGTTGAACCAATGGAATGTAAGATAATAGTTGCCCATGAAGACACGGATATGTCTTCTGATGCCTCGAACGATTCATCAATTTGTATAACGTCATCCGAACAGTTATTCGAAAAAGTGTATCATTACAAATTGTCCAAGTCGAATCCATCTTCTCCTGTAAACCCGCCAGCAATAAAATATCGATCCCTTTCGAGAGCTTCGTTACATTTGcctgaaaaattaaacgaaacTCTTGGCAATCAACATCTCAATAATGAGGCCAGCTGTGCCCAAAATTATCTCAAAGATAATTACAACGACGAAGATATGGAATTAGAAGTCAGTAATGGAGTCATTATTGAGCGAGAATCCCTTAAAGCTCGGCGCACCAAACCCGCTGAATCTCCTATGTTATACAACGAAGAGGAATATGAAGAAGAGGAAGACGACTCGGATGCGGATAGTTGCGAAGATGTGggtaaaaatgaagaagacgacgatgacgatgaagatgaagatgaagatgaagaggatgaagaagaggaagaagatgaagaagaagagcatATAGTTCATGGAGATAAAGCGCTGATGGAAAAAGATcctaataaatttgataatcaGTCATCTGTTTTTGTACCTATCGAAGAACAAGAACGAGCTACTGATCTTAGGGCACATAATGGCATTTCTGAAAGCTTTGGAACATCGAGTAACTTCTCTGTTGACCAAAATTTGCGAAAGCTATCCTCAGAAATGAGTGTCCTCCGTAACTATCCAATACTATCTAAAAACGAAAATGCTTTGAGTACATCAGATTCTATTGTAAGTGCGGATACCAGAACTATTTCTAGTTCTAACAAGGTATCTGCTCCAAAATCGTCATCAGAACTATTaaacatgaatgaaaatgCTCATGCTGGGCCTATCAATTTGTTTGAATACGACAGTCTTCGTTTACTTTTACCCAGTACATTGGACTGTGAATCTTCTCAGAAAGCCGTCAGTGTCGCGAGTCAACAATCATTGGCAAGCAGCGAAAACGAAGTTGGTGTTGATGAGGAGGTCAAAAGTGTAAATATGAGAGCTGATGAAACAATGCCTGCAAGAGGTGAACTATCTGAACAGGAAAGCAATGGCTTTACAGAACAATCAGCGTGGCAGTACGTGGGTCAAGATTCATCGCGTATGTCGACGTCTTATGATTTGATGGCTCGAGAAAGCTGGGAAGAATCCGAGGGTTCAGATCGCGACGATAACAATGCTTCAGAGCAGAATCACAATCTTCTTCTCGACAGCCGATCAATGGCCACACATTTTACTTCAAGTCTCTTTCTTGATCGAGATAGAAAAACTCCAACAAGAGGAGTATTCAAATGCTCCCATTGCCCAGAAGTATTTGATTGTCCAAAAGAACGTCGAGTTCATACCACTATGCTTCACAAAGAGGCAATTCCATCGAGTAGCTGTAGTAGCAGTACTGAAGCAATTACATTGACACATACAATTCAAGGTCAGCATCACGAGTTCAAAGATCTGAAGCATGTGGAAGCTCGAACAAATagttttgaagaaatttttgtgCAAACCGGTCATCCGTCACCACTTCTTCATGAAATGGAAACAGTTCGTCAGCGAGATTCCAATGCAGTTGATAATGatatgattaaatttgatcTGGCAAGACAAGGACACAAAACTTTTGCTGGTGATAAAGCTCTCATGCTCCAACgtgaaaaagttcaaatgaTGGTACCGCCTGCCAAGCGTGCACCACGTGAAGTAGCCAAGTGTCTGATTTGCAATGAAGAGTTTCCATCAGTTGGTAATTATAATCtccatttgaaaattcatcctTTGGAGTGCGGCCAATgtggtaaatatttttatcgaaagcAAAACTTTAGATTACACATGAAAAGACACATGGGTATCAAGCCATTCCCGTGTACGCGTTGCGACAAAGCTTTTCTCACAAAGCAAAAGTTAGATGAGCACATGAACGGACATACTGGTAACGCACCCGTAAAGTGTAATCTTTGCAATGAAACGTTTCGGCGATACTCTAACTTGACTCAACATAAGAATCGCCATCACTTAAacattaagaaaaaattaaaggatTACATTTGTCATTGCGGCGAAGTTTTTCatacgaagaaaaaactcGCATGGCATAAAGAAACTCACGATGAAAAACCCAAAGCATGTACCCATTGTAATGAAAGATTTGTTCATATGGCCAGCTTAACACGGCATATGCGACACGCTCATAATCGTCGCTTTGTCCCGGATGCTCaacgagaaaatgaaaacgttGAATGTCCGGTATGCCATTGTATATACCTTCGCTCGTCGTTAGCCGTACACATGCGGGTTCATAATGGAGAAAAACCTTACGAATGCCAAGTTTGTTCTAAAACATTCAGCACAAAATGGAATCTTCAACTCCACAAGTGGACTCATGCAGCCCGGAGTGCCAAACCATTCAAGTGTAATCAGTGCAGCGCCGCATTTTACCGAAACAGTGATTACACAGCTCACATGAATTCTCATCGTAACGTACGGCCTTATACATGCAATTTTTGTGGAGCTCAGTTTATCCGTAAGTACAATTGTTTGCGGCACGTTAAAGAGCACGAAGAAGACAAGCAGTATACCTGTGAAATATGCAACAAAACCTTTCACCGCTCGTATTATCTCAAAGAACATCAGCGCGTCCATTCGGGCCTTAGACCCTATACTTGTCACATATGTGGTAAATCAAGCAGCACTAAATCTAATCACAATAAGCATGTTAGAATTCATCATGCCCGTGAACCAGTTAACAcggaaaattaa
Protein Sequence
MDLTRAVSTMATNPSSGSGKVACPVCTLYLREGISLQEHLDTHPKEQVIEALIRASSSGLPLSNQQTPSPSQQKSSPTSQASQTALPDVSVPSSPTVSQGPHITPQHPSAPYPVGPIYECPPMIPPHFTSYSYQHYVNGVFSSGASPMVMPQYAVAQPQNPQTSQMMQMVYNPFSMYHQQLQPAVQMISSPTQQLPHPSTLATPLISTTSTATTAVSAPISASIAPRTRMNTPTSSACISEVIQPTSTLAISESTPRCLEKSKETTIVPDISNDQILPDLEVTSASETSSKNQEHNENIENPEEQVQRKECSQPKECHNENYECEEQTSSTNDKLENTVNDDKTERILPDIEDNDEIESLLVRETSSPQNEKDKNSDVQMREPREVQDTNIEVTQIEINSDKNVSKSSELNGEKINETNTSAESVEQQLDNGMQPTDLSISESRSTQKQPDIEDLHRIMEIISDLEKKSHVLQSALPKSTDDICLQNSSEKHLEAASSSHKQQIDEDENMSNVEPMECKIIVAHEDTDMSSDASNDSSICITSSEQLFEKVYHYKLSKSNPSSPVNPPAIKYRSLSRASLHLPEKLNETLGNQHLNNEASCAQNYLKDNYNDEDMELEVSNGVIIERESLKARRTKPAESPMLYNEEEYEEEEDDSDADSCEDVGKNEEDDDDDEDEDEDEEDEEEEEDEEEEHIVHGDKALMEKDPNKFDNQSSVFVPIEEQERATDLRAHNGISESFGTSSNFSVDQNLRKLSSEMSVLRNYPILSKNENALSTSDSIVSADTRTISSSNKVSAPKSSSELLNMNENAHAGPINLFEYDSLRLLLPSTLDCESSQKAVSVASQQSLASSENEVGVDEEVKSVNMRADETMPARGELSEQESNGFTEQSAWQYVGQDSSRMSTSYDLMARESWEESEGSDRDDNNASEQNHNLLLDSRSMATHFTSSLFLDRDRKTPTRGVFKCSHCPEVFDCPKERRVHTTMLHKEAIPSSSCSSSTEAITLTHTIQGQHHEFKDLKHVEARTNSFEEIFVQTGHPSPLLHEMETVRQRDSNAVDNDMIKFDLARQGHKTFAGDKALMLQREKVQMMVPPAKRAPREVAKCLICNEEFPSVGNYNLHLKIHPLECGQCGKYFYRKQNFRLHMKRHMGIKPFPCTRCDKAFLTKQKLDEHMNGHTGNAPVKCNLCNETFRRYSNLTQHKNRHHLNIKKKLKDYICHCGEVFHTKKKLAWHKETHDEKPKACTHCNERFVHMASLTRHMRHAHNRRFVPDAQRENENVECPVCHCIYLRSSLAVHMRVHNGEKPYECQVCSKTFSTKWNLQLHKWTHAARSAKPFKCNQCSAAFYRNSDYTAHMNSHRNVRPYTCNFCGAQFIRKYNCLRHVKEHEEDKQYTCEICNKTFHRSYYLKEHQRVHSGLRPYTCHICGKSSSTKSNHNKHVRIHHAREPVNTEN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
iTF_01483073;
80% Identity
-