Basic Information

Gene Symbol
ZFX
Assembly
GCA_034770305.1
Location
JAPMIB010000028.1:877364-882176[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 2.5 90 4.6 3.2 1 23 933 956 933 956 0.87
2 13 0.015 0.53 11.6 0.1 2 23 1072 1093 1072 1093 0.98
3 13 7.1e-05 0.0026 18.9 2.2 2 23 1096 1117 1095 1117 0.97
4 13 0.019 0.7 11.2 0.5 1 23 1123 1145 1123 1145 0.97
5 13 9.5e-05 0.0035 18.5 4.5 2 23 1152 1173 1151 1174 0.95
6 13 0.42 16 7.0 3.7 5 23 1187 1205 1186 1205 0.97
7 13 0.002 0.072 14.3 5.0 3 23 1212 1233 1211 1233 0.96
8 13 0.04 1.5 10.2 0.2 2 23 1249 1269 1248 1269 0.97
9 13 0.00016 0.0059 17.8 1.2 1 20 1275 1294 1275 1297 0.92
10 13 5e-05 0.0018 19.4 1.1 1 23 1305 1327 1305 1327 0.99
11 13 0.045 1.7 10.1 3.4 1 23 1333 1355 1333 1355 0.97
12 13 8.2e-06 0.0003 21.8 4.3 1 23 1361 1383 1361 1383 0.99
13 13 0.0012 0.043 15.1 7.2 1 23 1389 1411 1389 1412 0.96

Sequence Information

Coding Sequence
atggaTCTCACTAGAGCAGTAAGCACAATGGCAACTAATCCTTCATCAGGAAATGGAAAAGTGGCGTGTCCTGTCTGTACCTTATACCTTCGAGAAGGTATAAGTTTACAGGAACATTTGGATACTCATCCAAAAGAACAAGTTATTGAGGCACTCATAAGAGCAAGTAGTTCTGGTTTACCATTATTGAGCCAGCAAACGCCATCACctttacaacaaaaaagttcTCCAACATCTCAAGCATCACAAACAGCATTGCCTGATGTTAGTGTATCCTCAAGCCCAACAGTATCACAAGGTCCACATATAACACCTCAACATCCATCAGCGCCTTACCCAGTAGGACCAATATATGAATGCCCACCAATGATACCCCCACATTTTACAAGCTACAGTTATCAACATTATGTCAATGGTGGTGCAAGTCCCATGGTAATGCCTCAGTATGCTGTAGCTCAACCACAAAATCCACAAACAAGTCAGATGATGCAAATGGTATATAATCCATTCAGTATGTATCATCAACAACTGCAGCCTGCAGTGCAAATGATTTCAAGCCCAACGCAACAGTTACCTCATCCTTCAACACTTGCAACACCTCTGATATCTACATCATCAACAGCAACTACAGCTGTTTCAGCCCCAATCTCAGCTAGTATAGCTCCCAGGACAAGGATGAACCTACCAACTAGTAGTGCTTGTATAAGTGAAGTTATTCAACCGACTTCTACTTTATCTATATCAGAGTCAACACCAAGATGcttagaaaaatcaaaagaaactACAATTGTTCCAGATATCAGCAATGAACAAATATTACCAGATCTCGAAGTTACTTCAGCATCTGAAACTAACTCTAAAAACCAAGAACacgatgaaaatattgagaatCCAGAAGAACAAGTTCAACGTAAAGATTGTTCGCAACCAAAAGAATGCCACAACGAAAATTATGAATGTGAGGAGCAAACTTCATCTACGAACGATAAACTCGAGAATACCGTAAACGATGATAAAACCGAACGAATCCTTCCTGATATTGAAGACAATGATGAAATTGAATCACTTTTGGTTCGGGAAACTTCTTCACCACCGAacgaaaatgataaaaattctgATGTACAAATGCGTGAACCTCGAGAAGTGCACGATACTAATAAAGAAGTCACACAGATTGAAATAAATagcgataaaaatgtttcgaaaTCATCTGAATTGaatggtgaaaaaataaatgaaacgaATACTTCACCTGAATCTGTCGAGCAACAGCTCGATAATGGTATGCAACCGACAGATCTTTCAATTGGCGAATCACGTTCTACTCAAAAGCAACCTGACATCGAAGATTTGCACCGGATCATGGAAATAATCTCAGATCTAGAAAATAAAAGCCACGTCTTACAATCTGCGTTACCTAAAAGCACCGATGatatttgtttacaaaataGTTCCGAAAAACATTCGGAAACAGCCTCCTCTTCACACAAACAACAGATCGATGAAGATGAAAACATGAGCAATGTTGAACCAATGGAATGTAAGATAATAGTCGCCCATGAAGACACGGATATGTCTTCTGATGCCTCGAACGATTCATCAATTTGTATAACATCATCCGAACAGTTATTCGACAAAGTGTATCATTACAAATTGTCCAAGTCGAATCCATCTTCTCCTGTAAACCCGCCAGCAATAAAATATCGATCCCTTTCGAGAGCTTCGTTACATTCgcctgaaaaattaaacgaaactCTTCGCAATCAACATCTCAATAACGAGGCTAGCTGTGCCCAAAATTATCTGAAAGATAATTACAACGACGAGGATATGGAATTAGAAGTCAAGGAATATGAAGAAGAGGAAGACGACTCTGATGCGGATAGTTGCGAAGATGTgggtaaaaatgaagaagacgacgatgacgatgacgatgaagatgaagatgaagatgaagaggatgaagaagacgaagaagatgaagaagagcATATAGTGCATGGAGATAATGCGCTGATGGAAAAAGAttctaataaatttgataatcaGTCATCTGTTTTTGTACCTATCGAAGAACAAGAACGAGCTACTGATCTTAGGGCACATAATGGTATTTCTGAAAGCTTTGGAACATCGAGTAACTTCTCTGTTGACCAAAATTTGCGAAAGCTATCCTCAGAAATGAGTGTCCTCCGTAACTATCCAATACTGTCTAAAAGCGAAAATGCTTTGAGTACATCCGATTCTATTGTAAGTGCGGATACCAGAACTATTTCTAGTTCTAACAAGGTATCTGCTCCAAAATCGTCAACAGAACTATTAAACATGAATGAAAATGCTCATGCTGGGCCTATCAATTTGTTTGAATACGACAGTCTTCGTTTACTTTTACCCAGTACATTGGACTGCGAATCTTCTCAGAAAGCTGTAAGTGTCGCGAGTCAACAATCATTGGCAAGCAGCGAAAACGAAGTTGGTATTGATGAGGAGGTCAAAAGTGTAAATATGAGAGCTGATGAAACAATGCCTGCAAGAGGTGAACTATCTGAACAGGAAAGCAATGGCTTTACAGAACAATCAGCGTGgcagTATGTGGGTCAAGATTCATCGCGTATGTCAACGTCTTATGATTTGATGGCTCGAGAAAGCTGGGAAGAATCTGAGTGTTCAGATCGCGACGATAACAATGCTTCAGAGCAGAATCACAATCTTCTTCTCGACAGCCGATCAATGGCCACGCATTTTACTTCAAGTCTCTTTCTTGATCGAGATAGAAAAACTCCAACAAGAGGAGTATTCAAATGCTCCCATTGTCCAGAAGTATTTGATTGTCCAAAAGAACGTCGAGTTCATACCACCATGCTTCACAAAGAGGCGATTCCATCGAGTAgctgtagtagtagtactgaAGCAATTACGTTGACACATACAATTCAAGGTCAGCATCACGAGTTCAAAGATCTGAAGCACGTGGAAGCTCGAACAAATagttttgaagaaatttttgtacaaactGGTCATCCGTCACCACTTCTTCATGAAATGGAGACAGTTCGTCAGCGAGATCCCAATGCAGTTGATAATGATATGATTAAATTTGATCTGGCAAGACAAGGACATAAAGCTTTTGCTGGTGACAAAGCTCTCATGCTCCAGCGTGAAAAAGTTCAAATGATGGTACCGCCTGCCAAGCGTGCACCGCGCGAAGTAGCCAAGTGTCTGATTTGCAACGAAGAGTTTCCATCAGTTGGTAATTATAATCtccatttgaaaattcatcctTTGGAGTGTGGCCAATgtggtaaatatttttatcgaaagcAAAACTTCAGATTACACATGAAAAGACACATGGGTATCAAGCCATTCCCGTGTACGCGTTGCGACAAAGCTTTCCTCACAAAGCAAAAGTTAGATGAGCACATGAACGGACATACTGGTAACGCACCCGTAAAGTGCAATCTTTGCAATGAAACGTTCCGGCGATACTCTAACTTAACTCAACATAAGAATCGCCATCATCTAaacattaagaaaaaattaaaggattACATTTGTCATTGCGGCGAAGTTTTCCATACGAAGAAAAAACTCGCTTGGCATAAAGAAACTCACGATGAAAAACCCAAAGCATGTACCCATTGTAATGAAAGATTTGTTCATATGGCCAGCTTAACACGGCATATGCGACACGCTCACAATCGTCGCTTTGTCCCGGATGCTCaacgagaaaatgaaaacgtTGAATGTCCAGTATGCCATTTTATATACCTTCGCTCGTCGTTAGCCGTACATATGCGGGTTCATAATGGAGAAAAACCTTACGAATGTCAAGTTTGTTCTAAAACATTCAGCACAAAATGGAATCTTCAACTCCACAAGTGGACTCATGCAGCCCGCAGTGCCAAACCATTCAAGTGTAATCAGTGCAGCGCCGCATTTTACCGAAACAGTGATTACACAGCTCACATGAATTCTCATCGTAACGTACGGCCTTATACATGCAATTTTTGTGGAGCTCAGTTTATCCGTAAGTACAATTGTTTGCGGCACGTTAAAGAGCACGAAGAAGACAAGCAGTATACCTGTGAAATATGTAACAAAACCTTTCACCGCTCGTATTATCTCAAAGAACATCAGCGCGTACATTCGGGCCTTAGACCCTATACTTGTCACATATGTGGTAAATCAAGCAGCACTAAATCTAATCACAATAAACATGTTAGAATACATCATGCCCGTGAACCAGTTAACAcggaaaattaa
Protein Sequence
MDLTRAVSTMATNPSSGNGKVACPVCTLYLREGISLQEHLDTHPKEQVIEALIRASSSGLPLLSQQTPSPLQQKSSPTSQASQTALPDVSVSSSPTVSQGPHITPQHPSAPYPVGPIYECPPMIPPHFTSYSYQHYVNGGASPMVMPQYAVAQPQNPQTSQMMQMVYNPFSMYHQQLQPAVQMISSPTQQLPHPSTLATPLISTSSTATTAVSAPISASIAPRTRMNLPTSSACISEVIQPTSTLSISESTPRCLEKSKETTIVPDISNEQILPDLEVTSASETNSKNQEHDENIENPEEQVQRKDCSQPKECHNENYECEEQTSSTNDKLENTVNDDKTERILPDIEDNDEIESLLVRETSSPPNENDKNSDVQMREPREVHDTNKEVTQIEINSDKNVSKSSELNGEKINETNTSPESVEQQLDNGMQPTDLSIGESRSTQKQPDIEDLHRIMEIISDLENKSHVLQSALPKSTDDICLQNSSEKHSETASSSHKQQIDEDENMSNVEPMECKIIVAHEDTDMSSDASNDSSICITSSEQLFDKVYHYKLSKSNPSSPVNPPAIKYRSLSRASLHSPEKLNETLRNQHLNNEASCAQNYLKDNYNDEDMELEVKEYEEEEDDSDADSCEDVGKNEEDDDDDDDEDEDEDEEDEEDEEDEEEHIVHGDNALMEKDSNKFDNQSSVFVPIEEQERATDLRAHNGISESFGTSSNFSVDQNLRKLSSEMSVLRNYPILSKSENALSTSDSIVSADTRTISSSNKVSAPKSSTELLNMNENAHAGPINLFEYDSLRLLLPSTLDCESSQKAVSVASQQSLASSENEVGIDEEVKSVNMRADETMPARGELSEQESNGFTEQSAWQYVGQDSSRMSTSYDLMARESWEESECSDRDDNNASEQNHNLLLDSRSMATHFTSSLFLDRDRKTPTRGVFKCSHCPEVFDCPKERRVHTTMLHKEAIPSSSCSSSTEAITLTHTIQGQHHEFKDLKHVEARTNSFEEIFVQTGHPSPLLHEMETVRQRDPNAVDNDMIKFDLARQGHKAFAGDKALMLQREKVQMMVPPAKRAPREVAKCLICNEEFPSVGNYNLHLKIHPLECGQCGKYFYRKQNFRLHMKRHMGIKPFPCTRCDKAFLTKQKLDEHMNGHTGNAPVKCNLCNETFRRYSNLTQHKNRHHLNIKKKLKDYICHCGEVFHTKKKLAWHKETHDEKPKACTHCNERFVHMASLTRHMRHAHNRRFVPDAQRENENVECPVCHFIYLRSSLAVHMRVHNGEKPYECQVCSKTFSTKWNLQLHKWTHAARSAKPFKCNQCSAAFYRNSDYTAHMNSHRNVRPYTCNFCGAQFIRKYNCLRHVKEHEEDKQYTCEICNKTFHRSYYLKEHQRVHSGLRPYTCHICGKSSSTKSNHNKHVRIHHAREPVNTEN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01485495;
80% Identity
-