Basic Information

Insect: Tribolium castaneum
Gene Symbol: L_1
Assembly: GCA_000002335.3
Location: NC:188506-221743[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 20 0.028 1.6 8.8 0.5 1 23 83 105 83 105 0.97

2 20 0.08 4.7 7.4 4.8 1 23 111 133 111 133 0.97

3 20 8.2e-07 4.8e-05 23.1 3.2 1 23 139 161 139 161 0.99

4 20 0.00012 0.0071 16.3 0.3 1 23 167 189 167 189 0.99

5 20 0.00056 0.033 14.2 0.3 1 23 211 234 211 234 0.96

6 20 0.022 1.3 9.2 0.1 2 23 261 283 260 283 0.95

7 20 0.028 1.7 8.8 0.3 1 23 317 340 317 340 0.96

8 20 0.0064 0.38 10.8 0.0 3 23 439 459 438 459 0.97

9 20 0.00058 0.034 14.1 2.4 3 23 469 490 467 490 0.91

10 20 0.044 2.6 8.2 0.8 1 23 495 518 495 518 0.94

11 20 0.00064 0.038 14.0 4.6 1 23 581 604 581 604 0.97

12 20 1.5 87 3.4 2.1 1 23 647 670 647 671 0.82

13 20 0.00017 0.0099 15.8 2.7 2 23 683 704 682 704 0.97

14 20 0.0025 0.15 12.1 0.9 1 23 713 735 713 735 0.98

15 20 3.4 2e+02 2.3 0.6 3 23 744 764 743 764 0.95

16 20 0.22 13 6.0 0.2 1 14 809 822 809 823 0.89

17 20 0.087 5.1 7.3 0.1 2 23 851 872 850 872 0.90

18 20 0.0023 0.13 12.3 0.3 2 23 881 902 880 902 0.95

19 20 0.0069 0.4 10.7 0.0 1 23 910 932 910 932 0.96

20 20 0.023 1.4 9.1 1.6 1 23 939 961 939 961 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	20	0.028	1.6	8.8	0.5	1	23	83	105	83	105	0.97
2	20	0.08	4.7	7.4	4.8	1	23	111	133	111	133	0.97
3	20	8.2e-07	4.8e-05	23.1	3.2	1	23	139	161	139	161	0.99
4	20	0.00012	0.0071	16.3	0.3	1	23	167	189	167	189	0.99
5	20	0.00056	0.033	14.2	0.3	1	23	211	234	211	234	0.96
6	20	0.022	1.3	9.2	0.1	2	23	261	283	260	283	0.95
7	20	0.028	1.7	8.8	0.3	1	23	317	340	317	340	0.96
8	20	0.0064	0.38	10.8	0.0	3	23	439	459	438	459	0.97
9	20	0.00058	0.034	14.1	2.4	3	23	469	490	467	490	0.91
10	20	0.044	2.6	8.2	0.8	1	23	495	518	495	518	0.94
11	20	0.00064	0.038	14.0	4.6	1	23	581	604	581	604	0.97
12	20	1.5	87	3.4	2.1	1	23	647	670	647	671	0.82
13	20	0.00017	0.0099	15.8	2.7	2	23	683	704	682	704	0.97
14	20	0.0025	0.15	12.1	0.9	1	23	713	735	713	735	0.98
15	20	3.4	2e+02	2.3	0.6	3	23	744	764	743	764	0.95
16	20	0.22	13	6.0	0.2	1	14	809	822	809	823	0.89
17	20	0.087	5.1	7.3	0.1	2	23	851	872	850	872	0.90
18	20	0.0023	0.13	12.3	0.3	2	23	881	902	880	902	0.95
19	20	0.0069	0.4	10.7	0.0	1	23	910	932	910	932	0.96
20	20	0.023	1.4	9.1	1.6	1	23	939	961	939	961	0.97

Sequence Information

Coding Sequence: ATGTGTTGGTTTGTGCAACAGTTTTGGAATAATCAAAAGAAGTTAGATATGTCCAGACGGAAGCAAGCCAATCCTGCCAAATTAGATCCTCAGGAGGAGGACGACCTAGAAGCACAGCACTTGAGACTAGCCGAAGATGAAACGGCTGCCAGTTCCGCATCCGGTGGTTCTGGATGTGGCGAAACTCAGCCTTTTGACGATGAACAAGTGCAGGGAGATCAAGATCAAGATACCAAACCCGGACCATACAAATGCACGGTATGTGGAGAAAATTATTTAAAAGAAAAACTGCTCAGGGAGCACGAACAGAGTCACACTGACCATCTGCAATTCACTTGTGCTTATTGTCCTCGGCTTTTCAAGCACAAGCGATCGAGAGATCGCCACACGAAGCTCCACACTGGGGATAAAAAATATAAATGTCAGCAGTGCGATTCCGCCTTTTCACGAAGTGATCATCTTAAAATTCATATGAAAACACATGATAGTCGTAAACCATATAAATGTGGTACATGCAATAGGGGCTATAACACCGCCGCAGCTCTCTCGTCGCATCAACAAAGTCACTTGAAACAAGAATCTAGGTCCGGAAGTCGCACGAGTGGAGGAAGCACTCCCAGCCCCGGACTTTTCCGGTGCACTCATTGTGCCGAAACTTTCGGAAAACCGGATCTGCTACAGAGTCATGTCGCAATGGTCCACAGCGACACGGACTCGTCGCTAAGCCAAACTCCGGAGCCCTTATCAGAGTATCAAAACCAAATCGAAGACCTGAAAATCGTTTGCATGTACTGCTCGAAGGAGTTCCCCAGTTTGGAGCTGATGTACCAGCACACAAACATCGCCCATCGTGACGTCCCCAACGGCGTTACAACTTCCGTTTCCGTCTCCTCCCCCGCGATCCAAAACTCCCCAAAACCGGAAATTTGCCAAAACGGAACACCAACCTACGCCTGTGATAGATGCACGATGCAATTAGACTCGTTGCAGAACTTGAAAAACCACATAAACAACGTACACTGGCGTCCGGCCCTCTCGCCAAACCCCGTCAATTTCATGGGGATTGAGAAAAGCTACTCCCCGTTCCAGACCCAACCGACCGACCTGAGCCGCAAGAAGAAAAGCGAGGACAGTGCGGAGAAAGCGGTCAAGAAGAAGAAAGACCAGCACTCCCCCACTGCCATCAGTCCCTACGACTCCAACGACAAGCCCTGCATTTGCTCGTGTTGCTACGCCCAACTCCCAAACTTCAAAAGCTTCCTCCACCACATGGAGTCGCACGTAATCTCCTCGAACAACTCCCTCCTCGGCTTCTGCCCCGTCTGCGGCGAGCCTGGCCGGGACCCCGTCTCGTTCACCAACCACATTTTTAGCCACGCTATTGCTCAAGTACCTGGCCGGTGTTGCTACACTTGCAAGAAGTCCTTCGAAAGGCTGGAAGAGCTGCAGAAGCACCTGTTGGAAGTCCACGTCGTGTCGGTGTTCAAGTGTTCCATCTGCAACGATATTTTCGATACGAAGATTTCAATGCAGTTGCATCTGACGAACAAACACAGCGACGAATGCAAGCACTTCAAGTGCTACTTGTGCACGAATCAGGTGTTTCACGATCGACTTTCGGCAGAATTGCACATCTCCATGAAGCACTACCAGCAGTTCACGCCCTGTGTTGGTGCCAACCAACTGCTACGGTCGCAATACCAGGAGTTGGACACCAGGTTTCGCGACTATAACATGATTTTCCAGTGCACGTTCTGCCACAAAACCTTCAAGGACCAGTACTCGCAGTATATCCACATTTTGAAGGAGCACAACGAAAGCAAAGAGGGTGAAAAATTCATTTTGGATTCAGCAATGAACCCAAATCCGTCCAGATCGCCCAACTTCATGTTCCCCAAAATCGTGACCCCTGACCACGTGGAGCCCCTGGAATCGGTCTACACTTGTGATATATGCAACCGCAGTGATATAACCTCCGAATCGGACCTAATAAACCACAAGAAGCTCCACCACAGCAGCAAGAACAAGATCGGTCCCGTGAGCCTCCAATGCGCCTACTGCAACGAGTACTGCAAGTCGCGCACGGACCTGGAGAACCACATGAAGACCCACCAAGTGACCTGCGGCAAAGGCAAGCACAAGTGCAACATCTGCGACGAGATTTACTCCTCCACGTTGACCCTCGCCGACCACAAGCTCACCCACTGCAAGATCGTCGAGGGGAACAGTTGCGTCCAGTGCAAGTCGGTGCTAACCGACGAGAACTCCTTCTACAGCCACCAGCTGCAGCACAGCAACCCGGGGAAGCCCAACTCGCAGATCTCGCTCCCAGCGAACTGCATCATCTGCTGCCAGACGCTGCAGACGGACGTGGAGATCAAGCTCCACGCCAAGTTCCACCTGAAGCACCTGACGCAGAAGGAGTACATGTGCGGGGTCTGCAGCAAAGTGTTCGACAGCCAGGGGCAGCCCGCCAACGACGTCAACATCGTCGTGTGCAAAGACTGCGCGAAGAGTGAGGACGAGGGGAAAAAAGTGCCGAAACAGTTCGCGTGTATCCAGTGCCCCCAGACTTTCGACAGTGAAAGTGACGTGCAAAACCACGCTGCCATGCACATGCTGAACGAGGGGACGAACCTGGAGTGCCGCTTGTGCAAGCAGGTCTTCTCGTCGCCCCTCAAGCTGCAGACGCACCTAATCGAGCACAACTTCTACGGAATGAACCAGTACAGTTGTTACGTGTGTTCCTCGGTTTTCACGGCAGCTAGCGGCCTGCAAAGCCACATAATCGGGCATGGGCTGGACAGCAGACCCTATGAGTGTTCGCAATGCCAGATGAAGTTCTTCTTCCGGGCCGAGTTGGATAATCATAGGTTTGTGCACCTCCAGAAGAGCTATCCGATTCACAACGGGGGCGAGATCTACGAGAACAAGCCAAGCCCCCGGTATAAAATCTGTAAATACTGTTCGAACTCGTATCTGGACAACTCGTTTTTCGTAGAACATTTGAATCAGTGTCCCTTCAGGATAAGTCCGAAACGTGAGACTTTCGATAATGAAGTAGACAATAATATTAAACAAGAAGTAACAGAGATCGCGTCGGAGGAAAAAGATGAGCAATAA
Protein Sequence: MCWFVQQFWNNQKKLDMSRRKQANPAKLDPQEEDDLEAQHLRLAEDETAASSASGGSGCGETQPFDDEQVQGDQDQDTKPGPYKCTVCGENYLKEKLLREHEQSHTDHLQFTCAYCPRLFKHKRSRDRHTKLHTGDKKYKCQQCDSAFSRSDHLKIHMKTHDSRKPYKCGTCNRGYNTAAALSSHQQSHLKQESRSGSRTSGGSTPSPGLFRCTHCAETFGKPDLLQSHVAMVHSDTDSSLSQTPEPLSEYQNQIEDLKIVCMYCSKEFPSLELMYQHTNIAHRDVPNGVTTSVSVSSPAIQNSPKPEICQNGTPTYACDRCTMQLDSLQNLKNHINNVHWRPALSPNPVNFMGIEKSYSPFQTQPTDLSRKKKSEDSAEKAVKKKKDQHSPTAISPYDSNDKPCICSCCYAQLPNFKSFLHHMESHVISSNNSLLGFCPVCGEPGRDPVSFTNHIFSHAIAQVPGRCCYTCKKSFERLEELQKHLLEVHVVSVFKCSICNDIFDTKISMQLHLTNKHSDECKHFKCYLCTNQVFHDRLSAELHISMKHYQQFTPCVGANQLLRSQYQELDTRFRDYNMIFQCTFCHKTFKDQYSQYIHILKEHNESKEGEKFILDSAMNPNPSRSPNFMFPKIVTPDHVEPLESVYTCDICNRSDITSESDLINHKKLHHSSKNKIGPVSLQCAYCNEYCKSRTDLENHMKTHQVTCGKGKHKCNICDEIYSSTLTLADHKLTHCKIVEGNSCVQCKSVLTDENSFYSHQLQHSNPGKPNSQISLPANCIICCQTLQTDVEIKLHAKFHLKHLTQKEYMCGVCSKVFDSQGQPANDVNIVVCKDCAKSEDEGKKVPKQFACIQCPQTFDSESDVQNHAAMHMLNEGTNLECRLCKQVFSSPLKLQTHLIEHNFYGMNQYSCYVCSSVFTAASGLQSHIIGHGLDSRPYECSQCQMKFFFRAELDNHRFVHLQKSYPIHNGGEIYENKPSPRYKICKYCSNSYLDNSFFVEHLNQCPFRISPKRETFDNEVDNNIKQEVTEIASEEKDEQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01568303;
90% Identity: iTF_01481165;
80% Identity: -